MAIT cell activation augments adenovirus vector vaccine immunogenicity

Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment early immune responses and contribute to protection. We hypothesized that MAIT cells may have inherent adjuvant activity in vaccine platforms that use replication-incompetent adenovirus vectors. In mice and hum...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-01, Vol.371 (6528), p.521-526
Hauptverfasser:	Provine, Nicholas M, Amini, Ali, Garner, Lucy C, Spencer, Alexandra J, Dold, Christina, Hutchings, Claire, Silva Reyes, Laura, FitzPatrick, Michael E B, Chinnakannan, Senthil, Oguti, Blanche, Raymond, Meriel, Ulaszewska, Marta, Troise, Fulvia, Sharpe, Hannah, Morgan, Sophie B, Hinks, Timothy S C, Lambe, Teresa, Capone, Stefania, Folgori, Antonella, Barnes, Eleanor, Rollier, Christine S, Pollard, Andrew J, Klenerman, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - immunology Adenoviruses Animals Antigens CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Cytokines Dendritic cells Dendritic Cells - immunology Expression vectors Genetic Vectors - immunology Homeostasis Humans Immunization Immunogenicity Immunogenicity, Vaccine Interferon Interferon-alpha - metabolism Interleukin 18 Interleukin-18 - metabolism Invariants Lymphocyte Activation Lymphocytes Lymphocytes T Mice Mice, Inbred C57BL Microbiota Monocytes Mucosa Mucosal-Associated Invariant T Cells - immunology Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Vaccines Viral Vaccines - immunology Viruses α-Interferon
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