Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy

Neurotransmitter transporters (NTTs) are involved in the fine-tuning of brain neurotransmitter homeostasis. As such, they are implicated in a plethora of complex behaviors, including reward, movement, and cognition. During recent decades, compounds that modulate NTT functions have been developed. So...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2020-07, Vol.41 (7), p.446-463
Hauptverfasser:	Niello, Marco, Gradisch, Ralph, Loland, Claus Juul, Stockner, Thomas, Sitte, Harald H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Allosteric Site allostery competitive and noncompetitive inhibition Homeostasis Humans neurotransmission Neurotransmitter Agents Neurotransmitter Transport Proteins - drug effects therapy transporter
Online-Zugang:	Volltext
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