Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

The PI3Kγ isoform is activated by Gi-coupled GPCRs in myeloid cells, but the extent to which the two endogenous complexes of PI3Kγ, p101/p110γ and p84/p110γ, receive direct regulation through Gβγ or indirect regulation through RAS and the sufficiency of those inputs is controversial or unclear. We g...

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Veröffentlicht in:	Science signaling 2020-11, Vol.13 (656)
Hauptverfasser:	Rynkiewicz, Natalie K, Anderson, Karen E, Suire, Sabine, Collins, Daniel M, Karanasios, Eleftherios, Vadas, Oscar, Williams, Roger, Oxley, David, Clark, Jonathan, Stephens, Len R, Hawkins, Phillip T
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animal models Binding sites Cell activation Formyl peptides G protein-coupled receptors Inflammation Leukocyte migration Leukocytes (neutrophilic) Mutation Myeloid cells Neutrophils Peritonitis Phosphatidylinositol 3,4,5-triphosphate Regulation Regulatory subunits Signaling
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