Novel Analgesics with Peripheral Targets

A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize these. The review addresses targets acting exclusively or predominantly on sensory neurons, mediators involved in inflammation targeting sensory neurons, and mediators involved in a more general inflammatory p...

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Veröffentlicht in:	Neurotherapeutics 2020-07, Vol.17 (3), p.784-825
Hauptverfasser:	Ciotu, Cosmin I., Fischer, Michael J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics - administration & dosage Analgesics - chemistry Analgesics - metabolism Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - metabolism Biomedical and Life Sciences Biomedicine Drug Delivery Systems - methods Drug Delivery Systems - trends Humans Inflammation Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Neurobiology Neurology Neurosciences Neurosurgery Pain Pain - drug therapy Pain - metabolism Review Sensory neurons Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism
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