TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading

Neurofibrillary tangles (NFTs) composed of hyperphosphorylated and misfolded tau protein are a pathological hallmark of Alzheimer’s disease and other tauopathy conditions. Tau is predominantly an intraneuronal protein but is also secreted in physiological and pathological conditions. The extracellul...

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Veröffentlicht in:	Molecular psychiatry 2021-10, Vol.26 (10), p.5925-5939
Hauptverfasser:	Xu, Yin, Du, Shuqi, Marsh, Jacob A., Horie, Kanta, Sato, Chihiro, Ballabio, Andrea, Karch, Celeste M., Holtzman, David M., Zheng, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/51 14/19 38/77 631/378 64/110 692/699 82/80 Alzheimer's disease Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Behavioral Sciences Biological Psychology Development and progression Disease Models, Animal Exocytosis Genetic aspects Health aspects Immunotherapy Lysosomes Medicine Medicine & Public Health Mice Mice, Transgenic Mutants Neurodegenerative diseases Neurofibrillary tangles Neurological research Neurosciences Pathology Pharmacotherapy Protein folding Protein seeding Psychiatry Species Tau protein Tau proteins tau Proteins - genetics Transcription factors
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