SIRT2 Inhibition Improves Functional Motor Recovery After Peripheral Nerve Injury

Sirtuin-2 (Sirt2) is a member of the NAD (+)-dependent protein deacetylase family involved in neuroprotection, cellular metabolism, homeostasis, and stress responses after injury of the nervous system. So far, no data have been published describing the role of SIRT2 in motor functional recovery afte...

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Veröffentlicht in:	Neurotherapeutics 2020-07, Vol.17 (3), p.1197-1211
Hauptverfasser:	Romeo-Guitart, David, Leiva-Rodríguez, Tatiana, Casas, Caty
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferase Animals Axonogenesis Axotomy Biomedical and Life Sciences Biomedicine Cell culture Cell Line, Tumor Cellular stress response Epigenetics Histones Homeostasis Humans Mice Mice, Inbred C57BL Mice, Knockout Motor neurons NAD Nervous system Neurobiology Neurology Neuroprotection Neurosciences Neurosurgery Original Original Article p53 Protein Peripheral Nerve Injuries - genetics Peripheral Nerve Injuries - metabolism Peripheral Nerve Injuries - therapy Peripheral nerves Rats Rats, Sprague-Dawley Recovery (Medical) Recovery of function Recovery of Function - physiology Regeneration Sciatic nerve Sirtuin 2 - antagonists & inhibitors Sirtuin 2 - deficiency Sirtuin 2 - genetics Spinal cord Spinal Cord - metabolism
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