Analysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients
Background: HBeAg-negative chronic hepatitis B infection has a divergent clinical course from that of HBeAg-positive infection. Objectives: To analyze the frequency and to compare the different features of HBeAg-negative and HBeAg-positive chronic hepatitis B patients. Methods: One hundred and twent...
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| Veröffentlicht in: | African health sciences 2020-06, Vol.20 (2), p.649-655 |
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| creator | Fouad, Rabab Musa, Sherief Sabry, Dina Salama, Ahmad Abdel Alem, Shereen Atef, Mira Zayed, Naglaa |
| description | Background: HBeAg-negative chronic hepatitis B infection has a
divergent clinical course from that of HBeAg-positive infection.
Objectives: To analyze the frequency and to compare the different
features of HBeAg-negative and HBeAg-positive chronic hepatitis B
patients. Methods: One hundred and twenty one Egyptian patients with
chronic hepatitis B (CHB), underwent laboratory investigations and
transient elastography (TE). Comparisons according to HBeAg status were
conducted regarding their demographic, liver biochemical and virologic
characters. Results: 97 patients (80.2%) were HBeAg-negative while 24
patients (19.8%) were HBeAg-positive. HBeAg-negative patients were
significantly older in age than CHBeAg-positive patients (p=0.001). ALT
levels in HBeAg-negative patients were significantly lower than those
in HBeAg-positive patients (p=0.02), whereas serum albumin was lower in
the HBeAg-positive group (p=0.03). The percentage of HBV DNA higher
than 20000 IU/mL in HBeAg-negative patients was lower than those in
HBeAg-positive patients (p=0.24). Stages of fibrosis by TE showed that
30.9% of HBeAg-negative and 41.7% of HBeAg-positive had a fibrosis
score >F2. Four patients (3.3%) were diagnosed with HCC; all of whom
were HBeAg-negative. Conclusion: HBeAg-negative patients compared with
HBeAg-positive patients had older age, lower ALT and serum HBVDNA
levels, but more incidence of HCC. |
| doi_str_mv | 10.4314/ahs.v20i2.13 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7609103</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2458961406</sourcerecordid><originalsourceid>FETCH-LOGICAL-b385t-b0330329ab94c2f5e3a445769f7a5c47cffaa2d58c55b7747796c04fdd30dcef3</originalsourceid><addsrcrecordid>eNpVkc1uEzEUhS0EoiWwY428LBIT_DuON0ihKgSpEhtYWx6PPWM0sQfbiZSX6DPjJG1UVr4-99M5VzoAvMdoyShmn_WYl3uCPFli-gJcY0FkgziiL-vcrlDTSsSvwJuc_yBEWizxa3BFKW5p_V2Dh3XQ0yH7DKODZvLBGz1BHXq49ylOcfAGOqvLLtkMfYAbO-viS-W_QgvXofjBBniz6ex6-NgEO9Tt3p4MTlozx-xP0t1wmIvXAZoxxRoDx2dWx8mGkt-CV05P2b57fBfg97e7X7eb5v7n9x-36_umoytemg5RiiiRupPMEMct1Yxx0UonNDdMGOe0Jj1fGc47IZgQsjWIub6nqDfW0QX4cvadd93WVimUpCc1J7_V6aCi9ur_TfCjGuJeiRZJXNMX4ObRIMW_O5uL2vps7DTpYOMuK8L4SraYobain86oSTHnZN0lBiN1rFDVCtWpQoWPzh-en3aBnzqrwPIMdD7WwuyFMMlr9SRWyzGTWrmk_wC3oqwl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2458961406</pqid></control><display><type>article</type><title>Analysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>African Journals Online (Open Access)</source><source>Bioline International</source><source>PubMed Central</source><creator>Fouad, Rabab ; Musa, Sherief ; Sabry, Dina ; Salama, Ahmad ; Abdel Alem, Shereen ; Atef, Mira ; Zayed, Naglaa</creator><creatorcontrib>Fouad, Rabab ; Musa, Sherief ; Sabry, Dina ; Salama, Ahmad ; Abdel Alem, Shereen ; Atef, Mira ; Zayed, Naglaa</creatorcontrib><description>Background: HBeAg-negative chronic hepatitis B infection has a
divergent clinical course from that of HBeAg-positive infection.
Objectives: To analyze the frequency and to compare the different
features of HBeAg-negative and HBeAg-positive chronic hepatitis B
patients. Methods: One hundred and twenty one Egyptian patients with
chronic hepatitis B (CHB), underwent laboratory investigations and
transient elastography (TE). Comparisons according to HBeAg status were
conducted regarding their demographic, liver biochemical and virologic
characters. Results: 97 patients (80.2%) were HBeAg-negative while 24
patients (19.8%) were HBeAg-positive. HBeAg-negative patients were
significantly older in age than CHBeAg-positive patients (p=0.001). ALT
levels in HBeAg-negative patients were significantly lower than those
in HBeAg-positive patients (p=0.02), whereas serum albumin was lower in
the HBeAg-positive group (p=0.03). The percentage of HBV DNA higher
than 20000 IU/mL in HBeAg-negative patients was lower than those in
HBeAg-positive patients (p=0.24). Stages of fibrosis by TE showed that
30.9% of HBeAg-negative and 41.7% of HBeAg-positive had a fibrosis
score >F2. Four patients (3.3%) were diagnosed with HCC; all of whom
were HBeAg-negative. Conclusion: HBeAg-negative patients compared with
HBeAg-positive patients had older age, lower ALT and serum HBVDNA
levels, but more incidence of HCC.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>EISSN: 1680-6905</identifier><identifier>DOI: 10.4314/ahs.v20i2.13</identifier><identifier>PMID: 33163026</identifier><language>eng</language><publisher>Uganda: Makerere University Medical School</publisher><subject>Adult ; Aged ; Alanine Transaminase - blood ; DNA, Viral - blood ; Egypt ; Egypt - epidemiology ; Female ; fibrosis ; HBeAg ; Hepatitis B ; Hepatitis B e Antigens - blood ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - blood ; Hepatitis B, Chronic - epidemiology ; Hepatitis B, Chronic - pathology ; Humans ; Liver - pathology ; Male ; Middle Aged</subject><ispartof>African health sciences, 2020-06, Vol.20 (2), p.649-655</ispartof><rights>Copyright 2020 - Fouad R et al.</rights><rights>2020 Fouad R et al.</rights><rights>2020 Fouad R et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b385t-b0330329ab94c2f5e3a445769f7a5c47cffaa2d58c55b7747796c04fdd30dcef3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609103/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609103/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774,79175</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33163026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fouad, Rabab</creatorcontrib><creatorcontrib>Musa, Sherief</creatorcontrib><creatorcontrib>Sabry, Dina</creatorcontrib><creatorcontrib>Salama, Ahmad</creatorcontrib><creatorcontrib>Abdel Alem, Shereen</creatorcontrib><creatorcontrib>Atef, Mira</creatorcontrib><creatorcontrib>Zayed, Naglaa</creatorcontrib><title>Analysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>Background: HBeAg-negative chronic hepatitis B infection has a
divergent clinical course from that of HBeAg-positive infection.
Objectives: To analyze the frequency and to compare the different
features of HBeAg-negative and HBeAg-positive chronic hepatitis B
patients. Methods: One hundred and twenty one Egyptian patients with
chronic hepatitis B (CHB), underwent laboratory investigations and
transient elastography (TE). Comparisons according to HBeAg status were
conducted regarding their demographic, liver biochemical and virologic
characters. Results: 97 patients (80.2%) were HBeAg-negative while 24
patients (19.8%) were HBeAg-positive. HBeAg-negative patients were
significantly older in age than CHBeAg-positive patients (p=0.001). ALT
levels in HBeAg-negative patients were significantly lower than those
in HBeAg-positive patients (p=0.02), whereas serum albumin was lower in
the HBeAg-positive group (p=0.03). The percentage of HBV DNA higher
than 20000 IU/mL in HBeAg-negative patients was lower than those in
HBeAg-positive patients (p=0.24). Stages of fibrosis by TE showed that
30.9% of HBeAg-negative and 41.7% of HBeAg-positive had a fibrosis
score >F2. Four patients (3.3%) were diagnosed with HCC; all of whom
were HBeAg-negative. Conclusion: HBeAg-negative patients compared with
HBeAg-positive patients had older age, lower ALT and serum HBVDNA
levels, but more incidence of HCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Alanine Transaminase - blood</subject><subject>DNA, Viral - blood</subject><subject>Egypt</subject><subject>Egypt - epidemiology</subject><subject>Female</subject><subject>fibrosis</subject><subject>HBeAg</subject><subject>Hepatitis B</subject><subject>Hepatitis B e Antigens - blood</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - blood</subject><subject>Hepatitis B, Chronic - epidemiology</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><issn>1680-6905</issn><issn>1729-0503</issn><issn>1680-6905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><recordid>eNpVkc1uEzEUhS0EoiWwY428LBIT_DuON0ihKgSpEhtYWx6PPWM0sQfbiZSX6DPjJG1UVr4-99M5VzoAvMdoyShmn_WYl3uCPFli-gJcY0FkgziiL-vcrlDTSsSvwJuc_yBEWizxa3BFKW5p_V2Dh3XQ0yH7DKODZvLBGz1BHXq49ylOcfAGOqvLLtkMfYAbO-viS-W_QgvXofjBBniz6ex6-NgEO9Tt3p4MTlozx-xP0t1wmIvXAZoxxRoDx2dWx8mGkt-CV05P2b57fBfg97e7X7eb5v7n9x-36_umoytemg5RiiiRupPMEMct1Yxx0UonNDdMGOe0Jj1fGc47IZgQsjWIub6nqDfW0QX4cvadd93WVimUpCc1J7_V6aCi9ur_TfCjGuJeiRZJXNMX4ObRIMW_O5uL2vps7DTpYOMuK8L4SraYobain86oSTHnZN0lBiN1rFDVCtWpQoWPzh-en3aBnzqrwPIMdD7WwuyFMMlr9SRWyzGTWrmk_wC3oqwl</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Fouad, Rabab</creator><creator>Musa, Sherief</creator><creator>Sabry, Dina</creator><creator>Salama, Ahmad</creator><creator>Abdel Alem, Shereen</creator><creator>Atef, Mira</creator><creator>Zayed, Naglaa</creator><general>Makerere University Medical School</general><general>Makerere Medical School</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200601</creationdate><title>Analysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients</title><author>Fouad, Rabab ; Musa, Sherief ; Sabry, Dina ; Salama, Ahmad ; Abdel Alem, Shereen ; Atef, Mira ; Zayed, Naglaa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b385t-b0330329ab94c2f5e3a445769f7a5c47cffaa2d58c55b7747796c04fdd30dcef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alanine Transaminase - blood</topic><topic>DNA, Viral - blood</topic><topic>Egypt</topic><topic>Egypt - epidemiology</topic><topic>Female</topic><topic>fibrosis</topic><topic>HBeAg</topic><topic>Hepatitis B</topic><topic>Hepatitis B e Antigens - blood</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis B, Chronic - blood</topic><topic>Hepatitis B, Chronic - epidemiology</topic><topic>Hepatitis B, Chronic - pathology</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fouad, Rabab</creatorcontrib><creatorcontrib>Musa, Sherief</creatorcontrib><creatorcontrib>Sabry, Dina</creatorcontrib><creatorcontrib>Salama, Ahmad</creatorcontrib><creatorcontrib>Abdel Alem, Shereen</creatorcontrib><creatorcontrib>Atef, Mira</creatorcontrib><creatorcontrib>Zayed, Naglaa</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fouad, Rabab</au><au>Musa, Sherief</au><au>Sabry, Dina</au><au>Salama, Ahmad</au><au>Abdel Alem, Shereen</au><au>Atef, Mira</au><au>Zayed, Naglaa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>20</volume><issue>2</issue><spage>649</spage><epage>655</epage><pages>649-655</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><eissn>1680-6905</eissn><abstract>Background: HBeAg-negative chronic hepatitis B infection has a
divergent clinical course from that of HBeAg-positive infection.
Objectives: To analyze the frequency and to compare the different
features of HBeAg-negative and HBeAg-positive chronic hepatitis B
patients. Methods: One hundred and twenty one Egyptian patients with
chronic hepatitis B (CHB), underwent laboratory investigations and
transient elastography (TE). Comparisons according to HBeAg status were
conducted regarding their demographic, liver biochemical and virologic
characters. Results: 97 patients (80.2%) were HBeAg-negative while 24
patients (19.8%) were HBeAg-positive. HBeAg-negative patients were
significantly older in age than CHBeAg-positive patients (p=0.001). ALT
levels in HBeAg-negative patients were significantly lower than those
in HBeAg-positive patients (p=0.02), whereas serum albumin was lower in
the HBeAg-positive group (p=0.03). The percentage of HBV DNA higher
than 20000 IU/mL in HBeAg-negative patients was lower than those in
HBeAg-positive patients (p=0.24). Stages of fibrosis by TE showed that
30.9% of HBeAg-negative and 41.7% of HBeAg-positive had a fibrosis
score >F2. Four patients (3.3%) were diagnosed with HCC; all of whom
were HBeAg-negative. Conclusion: HBeAg-negative patients compared with
HBeAg-positive patients had older age, lower ALT and serum HBVDNA
levels, but more incidence of HCC.</abstract><cop>Uganda</cop><pub>Makerere University Medical School</pub><pmid>33163026</pmid><doi>10.4314/ahs.v20i2.13</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | African health sciences, 2020-06, Vol.20 (2), p.649-655 |
| issn | 1680-6905 1729-0503 1680-6905 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7609103 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; African Journals Online (Open Access); Bioline International; PubMed Central |
| subjects | Adult Aged Alanine Transaminase - blood DNA, Viral - blood Egypt Egypt - epidemiology Female fibrosis HBeAg Hepatitis B Hepatitis B e Antigens - blood Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - blood Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - pathology Humans Liver - pathology Male Middle Aged |
| title | Analysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients |
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