Lipocalin-2 Exacerbates Lupus Nephritis by Promoting Th1 Cell Differentiation

Lipocalin-2 (LCN2) is an indicator of the severity of lupus nephritis (LN) and plays a pivotal role in immune responses, but it is not known if its effect on LN pathogenesis derives from regulating the immune imbalance of T lymphocyte subsets. The expression of LCN2 in T cells and kidneys was assess...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2020-10, Vol.31 (10), p.2263-2277
Hauptverfasser:	Chen, Weiwei, Li, Wenchao, Zhang, Zhuoya, Tang, Xiaojun, Wu, Shufang, Yao, Genhong, Li, Kang, Wang, Dandan, Xu, Yuemei, Feng, Ruihai, Duan, Xiaoxiao, Fan, Xiangshan, Lu, Liwei, Chen, WanJun, Li, Chaojun, Sun, Lingyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Research Case-Control Studies Cell Differentiation Disease Models, Animal Female Humans Lipocalin-2 - metabolism Lupus Nephritis - etiology Lupus Nephritis - metabolism Lupus Nephritis - pathology Male Mice Mice, Inbred MRL lpr Th1 Cells - metabolism Th1 Cells - pathology
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