Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription

CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few additional CDK7 substrates are known. Here, using the covalent inhibitor SY-351 and quantitative phosphoproteomics, we identified CDK7 kinas...

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Veröffentlicht in:	Genes & development 2020-11, Vol.34 (21-22), p.1452-1473
Hauptverfasser:	Rimel, Jenna K, Poss, Zachary C, Erickson, Benjamin, Maas, Zachary L, Ebmeier, Christopher C, Johnson, Jared L, Decker, Tim-Michael, Yaron, Tomer M, Bradley, Michael J, Hamman, Kristin B, Hu, Shanhu, Malojcic, Goran, Marineau, Jason J, White, Peter W, Brault, Martine, Tao, Limei, DeRoy, Patrick, Clavette, Christian, Nayak, Shraddha, Damon, Leah J, Kaltheuner, Ines H, Bunch, Heeyoun, Cantley, Lewis C, Geyer, Matthias, Iwasa, Janet, Dowell, Robin D, Bentley, David L, Old, William M, Taatjes, Dylan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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