A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals

Catalytic-inactivating mutations within the enhancer H3K4 mono-methyltransferase Trr and its mammalian homologs, MLL3/4, cause only minor changes in gene expression compared with whole-gene deletions for these COMPASS members. To identify essential histone methyltransferase-independent functions of...

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Veröffentlicht in:	Genes & development 2020-11, Vol.34 (21-22), p.1493-1502
Hauptverfasser:	Rickels, Ryan, Wang, Lu, Iwanaszko, Marta, Ozark, Patrick A, Morgan, Marc A, Piunti, Andrea, Khalatyan, Natalia, Soliman, Shimaa H A, Rendleman, Emily J, Savas, Jeffrey N, Smith, Edwin R, Shilatifard, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Conserved Sequence - genetics DNA-Binding Proteins - genetics Drosophila melanogaster - genetics Drosophila Proteins - genetics Gene Deletion Gene Expression Regulation - genetics Genes, Lethal - genetics HCT116 Cells Histone-Lysine N-Methyltransferase - genetics Humans Oxidoreductases, N-Demethylating - genetics Protein Domains Protein Stability Research Paper
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