Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system

Drug-evoked adaptations in the mesolimbic dopamine system are postulated to drive opioid abuse and addiction. These adaptations vary in magnitude and direction following different patterns of opioid exposure, but few studies have systematically manipulated the pattern of opioid administration while...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2020-10, Vol.45 (11), p.1781-1792
Hauptverfasser:	Lefevre, Emilia M, Pisansky, Marc T, Toddes, Carlee, Baruffaldi, Federico, Pravetoni, Marco, Tian, Lin, Kono, Thomas J Y, Rothwell, Patrick E
Format:	Artikel
Sprache:	eng
Schlagworte:	Abuse Adaptation Addictions Analgesics, Opioid Animal behavior Animals Brain Caudate-putamen Dopamine Drug tolerance Female Gene expression Genomes Male Mesolimbic system Mice Morphine Naloxone Narcotics Neostriatum Nucleus Accumbens Opioids Pharmaceutical Preparations Photometry Reinforcement Ribonucleic acid RNA Transcription Withdrawal
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