Prevalence, risk factors and disease knowledge of polycystic kidney disease in Pakistan
Polycystic kidneys disease refers to cyst(s) formation in kidneys with severe consequences of end stage renal disease thus have higher mortality. It is a common genetic disease occurring either as autosomal dominant polycystic kidney (ADPKD) or autosomal recessive polycystic kidney disease (ARPKD) w...
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| Veröffentlicht in: | International journal of immunopathology and pharmacology 2020, Vol.34, p.2058738420966083-2058738420966083 |
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| creator | Zahid, Rabia Akram, Muhammad Rafique, Ejaz |
| description | Polycystic kidneys disease refers to cyst(s) formation in kidneys with severe consequences of end stage renal disease thus have higher mortality. It is a common genetic disease occurring either as autosomal dominant polycystic kidney (ADPKD) or autosomal recessive polycystic kidney disease (ARPKD) with prevalence rates of 1/1000 and 1/40,000 respectively. Dominant forms presenting in later (>30) while recessive in earlier ages (infancy) and affecting both sexes and almost all race. The patient experiences many renal as well as extra-renal manifestations with marked hypertension and cyst formation in other organs predominantly in liver. Due to genetic basis, positive family history is considered as major risk factor. Ultrasonography remains the main stay of diagnosis along with family history, by indicating increased renal size and architectural modifications. Initially disease remains asymptomatic, later on symptomatic treatment is suggested with surgical interventions like cyst decortications or drainage. Dialysis proved to be beneficial in end stage renal disease. However renal transplantation is the treatment of choice. |
| doi_str_mv | 10.1177/2058738420966083 |
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It is a common genetic disease occurring either as autosomal dominant polycystic kidney (ADPKD) or autosomal recessive polycystic kidney disease (ARPKD) with prevalence rates of 1/1000 and 1/40,000 respectively. Dominant forms presenting in later (>30) while recessive in earlier ages (infancy) and affecting both sexes and almost all race. The patient experiences many renal as well as extra-renal manifestations with marked hypertension and cyst formation in other organs predominantly in liver. Due to genetic basis, positive family history is considered as major risk factor. Ultrasonography remains the main stay of diagnosis along with family history, by indicating increased renal size and architectural modifications. Initially disease remains asymptomatic, later on symptomatic treatment is suggested with surgical interventions like cyst decortications or drainage. Dialysis proved to be beneficial in end stage renal disease. However renal transplantation is the treatment of choice.</description><identifier>ISSN: 2058-7384</identifier><identifier>ISSN: 0394-6320</identifier><identifier>EISSN: 2058-7384</identifier><identifier>DOI: 10.1177/2058738420966083</identifier><identifier>PMID: 33125856</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Cysts ; Dialysis ; Disease Progression ; Family medical history ; Female ; Genetic Predisposition to Disease ; Humans ; Kidney diseases ; Kidney transplantation ; Male ; Medical treatment ; Middle Aged ; Pakistan - epidemiology ; Polycystic kidney ; Polycystic Kidney, Autosomal Dominant - diagnosis ; Polycystic Kidney, Autosomal Dominant - epidemiology ; Polycystic Kidney, Autosomal Dominant - genetics ; Polycystic Kidney, Autosomal Dominant - therapy ; Polycystic Kidney, Autosomal Recessive - diagnosis ; Polycystic Kidney, Autosomal Recessive - epidemiology ; Polycystic Kidney, Autosomal Recessive - genetics ; Polycystic Kidney, Autosomal Recessive - therapy ; Prevalence ; Prognosis ; Renal Replacement Therapy ; Risk Assessment ; Risk Factors ; TRPP Cation Channels - genetics</subject><ispartof>International journal of immunopathology and pharmacology, 2020, Vol.34, p.2058738420966083-2058738420966083</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-53e29bc448e66faad1f448f13219145311a62adcd6b7ce988d32886941865b0f3</citedby><cites>FETCH-LOGICAL-c462t-53e29bc448e66faad1f448f13219145311a62adcd6b7ce988d32886941865b0f3</cites><orcidid>0000-0002-3832-0056 ; 0000-0001-7863-8803</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607775/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607775/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4023,21965,27852,27922,27923,27924,44944,45332,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33125856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zahid, Rabia</creatorcontrib><creatorcontrib>Akram, Muhammad</creatorcontrib><creatorcontrib>Rafique, Ejaz</creatorcontrib><title>Prevalence, risk factors and disease knowledge of polycystic kidney disease in Pakistan</title><title>International journal of immunopathology and pharmacology</title><addtitle>Int J Immunopathol Pharmacol</addtitle><description>Polycystic kidneys disease refers to cyst(s) formation in kidneys with severe consequences of end stage renal disease thus have higher mortality. It is a common genetic disease occurring either as autosomal dominant polycystic kidney (ADPKD) or autosomal recessive polycystic kidney disease (ARPKD) with prevalence rates of 1/1000 and 1/40,000 respectively. Dominant forms presenting in later (>30) while recessive in earlier ages (infancy) and affecting both sexes and almost all race. The patient experiences many renal as well as extra-renal manifestations with marked hypertension and cyst formation in other organs predominantly in liver. Due to genetic basis, positive family history is considered as major risk factor. Ultrasonography remains the main stay of diagnosis along with family history, by indicating increased renal size and architectural modifications. Initially disease remains asymptomatic, later on symptomatic treatment is suggested with surgical interventions like cyst decortications or drainage. Dialysis proved to be beneficial in end stage renal disease. However renal transplantation is the treatment of choice.</description><subject>Adult</subject><subject>Aged</subject><subject>Cysts</subject><subject>Dialysis</subject><subject>Disease Progression</subject><subject>Family medical history</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Pakistan - epidemiology</subject><subject>Polycystic kidney</subject><subject>Polycystic Kidney, Autosomal Dominant - diagnosis</subject><subject>Polycystic Kidney, Autosomal Dominant - epidemiology</subject><subject>Polycystic Kidney, Autosomal Dominant - genetics</subject><subject>Polycystic Kidney, Autosomal Dominant - therapy</subject><subject>Polycystic Kidney, Autosomal Recessive - diagnosis</subject><subject>Polycystic Kidney, Autosomal Recessive - epidemiology</subject><subject>Polycystic Kidney, Autosomal Recessive - genetics</subject><subject>Polycystic Kidney, Autosomal Recessive - therapy</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Renal Replacement Therapy</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>TRPP Cation Channels - genetics</subject><issn>2058-7384</issn><issn>0394-6320</issn><issn>2058-7384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kc9rVDEQx4MottTePUnAiwefZvL7XQQp_oKCPSgeQzaZt6b7NlmTty373_uWrWsteJph5jPfmeFLyHNgbwCMecuZskZYyVmvNbPiETndl7p97fG9_ISct3bNGAMmpLLwlJwIAVxZpU_Jj6uKN37EHPA1ramt6ODDVGqjPkcaU0PfkK5yuR0xLpGWgW7KuAu7NqVAVylm3B2xlOmVX6U2-fyMPBn82PD8Lp6R7x8_fLv43F1-_fTl4v1lF6TmU6cE8n4RpLSo9eB9hGHOBxAcepBKAHjNfQxRL0zA3toouLW6l2C1WrBBnJF3B93NdrHGGDBP1Y9uU9Pa150rPrl_Ozn9dMty44xmxhg1C7y6E6jl1xbb5NapBRxHn7Fsm-NSaQlgLczoywfoddnWPL83U0YYLkCxmWIHKtTSWsXheAwwtzfOPTRuHnlx_4njwB-bZqA7AM0v8e_W_wr-BgCtn-I</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Zahid, Rabia</creator><creator>Akram, Muhammad</creator><creator>Rafique, Ejaz</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3832-0056</orcidid><orcidid>https://orcid.org/0000-0001-7863-8803</orcidid></search><sort><creationdate>2020</creationdate><title>Prevalence, risk factors and disease knowledge of polycystic kidney disease in Pakistan</title><author>Zahid, Rabia ; Akram, Muhammad ; Rafique, Ejaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-53e29bc448e66faad1f448f13219145311a62adcd6b7ce988d32886941865b0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cysts</topic><topic>Dialysis</topic><topic>Disease Progression</topic><topic>Family medical history</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney transplantation</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Pakistan - epidemiology</topic><topic>Polycystic kidney</topic><topic>Polycystic Kidney, Autosomal Dominant - diagnosis</topic><topic>Polycystic Kidney, Autosomal Dominant - epidemiology</topic><topic>Polycystic Kidney, Autosomal Dominant - genetics</topic><topic>Polycystic Kidney, Autosomal Dominant - therapy</topic><topic>Polycystic Kidney, Autosomal Recessive - diagnosis</topic><topic>Polycystic Kidney, Autosomal Recessive - epidemiology</topic><topic>Polycystic Kidney, Autosomal Recessive - genetics</topic><topic>Polycystic Kidney, Autosomal Recessive - therapy</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Renal Replacement Therapy</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>TRPP Cation Channels - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zahid, Rabia</creatorcontrib><creatorcontrib>Akram, Muhammad</creatorcontrib><creatorcontrib>Rafique, Ejaz</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of immunopathology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zahid, Rabia</au><au>Akram, Muhammad</au><au>Rafique, Ejaz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence, risk factors and disease knowledge of polycystic kidney disease in Pakistan</atitle><jtitle>International journal of immunopathology and pharmacology</jtitle><addtitle>Int J Immunopathol Pharmacol</addtitle><date>2020</date><risdate>2020</risdate><volume>34</volume><spage>2058738420966083</spage><epage>2058738420966083</epage><pages>2058738420966083-2058738420966083</pages><issn>2058-7384</issn><issn>0394-6320</issn><eissn>2058-7384</eissn><abstract>Polycystic kidneys disease refers to cyst(s) formation in kidneys with severe consequences of end stage renal disease thus have higher mortality. It is a common genetic disease occurring either as autosomal dominant polycystic kidney (ADPKD) or autosomal recessive polycystic kidney disease (ARPKD) with prevalence rates of 1/1000 and 1/40,000 respectively. Dominant forms presenting in later (>30) while recessive in earlier ages (infancy) and affecting both sexes and almost all race. The patient experiences many renal as well as extra-renal manifestations with marked hypertension and cyst formation in other organs predominantly in liver. Due to genetic basis, positive family history is considered as major risk factor. Ultrasonography remains the main stay of diagnosis along with family history, by indicating increased renal size and architectural modifications. Initially disease remains asymptomatic, later on symptomatic treatment is suggested with surgical interventions like cyst decortications or drainage. Dialysis proved to be beneficial in end stage renal disease. However renal transplantation is the treatment of choice.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33125856</pmid><doi>10.1177/2058738420966083</doi><orcidid>https://orcid.org/0000-0002-3832-0056</orcidid><orcidid>https://orcid.org/0000-0001-7863-8803</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Cysts Dialysis Disease Progression Family medical history Female Genetic Predisposition to Disease Humans Kidney diseases Kidney transplantation Male Medical treatment Middle Aged Pakistan - epidemiology Polycystic kidney Polycystic Kidney, Autosomal Dominant - diagnosis Polycystic Kidney, Autosomal Dominant - epidemiology Polycystic Kidney, Autosomal Dominant - genetics Polycystic Kidney, Autosomal Dominant - therapy Polycystic Kidney, Autosomal Recessive - diagnosis Polycystic Kidney, Autosomal Recessive - epidemiology Polycystic Kidney, Autosomal Recessive - genetics Polycystic Kidney, Autosomal Recessive - therapy Prevalence Prognosis Renal Replacement Therapy Risk Assessment Risk Factors TRPP Cation Channels - genetics |
| title | Prevalence, risk factors and disease knowledge of polycystic kidney disease in Pakistan |
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