Glomerular filtration and podocyte tensional homeostasis: importance of the minor type IV collagen network

The minor type IV collagen chain, which is a significant component of the glomerular basement membrane in healthy individuals, is known to assemble into large structures (supercoils) that may contribute to the mechanical stability of the collagen network and the glomerular basement membrane as a who...

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Veröffentlicht in:	Biomechanics and modeling in mechanobiology 2020-12, Vol.19 (6), p.2433-2442
Hauptverfasser:	Bersie-Larson, Lauren M., Gyoneva, Lazarina, Goodman, Daniel J., Dorfman, Kevin D., Segal, Yoav, Barocas, Victor H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alport syndrome Basements Biological and Medical Physics Biomedical Engineering and Bioengineering Biophysics Capillaries - metabolism Capillary pressure Chains Collagen Collagen (type IV) Collagen Type IV - chemistry Continuum modeling Cytoskeleton Engineering Extracellular Matrix Feedback loops Fibers Filtration Glomerular Basement Membrane - metabolism Glomerular Filtration Rate Homeostasis Humans Kidney - metabolism Kidney - physiology Kidneys Membrane permeability Membranes Nephritis, Hereditary - metabolism Original Paper Permeability Podocytes - cytology Pressure Pressure drop Renal failure Stiffness Stress, Mechanical Theoretical and Applied Mechanics Thickening
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