Nimodipine improves cortical efficiency during working memory in healthy subjects

The L-type calcium channel gene, CACNA1C, is a validated risk gene for schizophrenia and the target of calcium channel blockers. Carriers of the risk-associated genotype (rs1006737 A allele) have increased frontal cortical activity during working memory and higher CACNA1C mRNA expression in the pref...

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Veröffentlicht in:	Translational psychiatry 2020-11, Vol.10 (1), p.372, Article 372
Hauptverfasser:	Zink, Caroline F., Giegerich, Mellissa, Prettyman, Greer E., Carta, Kayla E., van Ginkel, Marcus, O’Rourke, Molly P., Singh, Eesha, Fuchs, Edward J., Hendrix, Craig W., Zimmerman, Eric, Breakey, Jennifer, Marzinke, Mark A., Hummert, Pamela, Pillai, Jay J., Weinberger, Daniel R., Bigos, Kristin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/61 59/36 631/154/436/108 631/208/1516 692/53/2423 692/699/476/1799 Behavioral Sciences Biological Psychology Calcium Channel Blockers - pharmacology Healthy Volunteers Humans Male Medicine Medicine & Public Health Memory Memory, Short-Term - drug effects Neurosciences Nimodipine - pharmacology Pharmacotherapy Prefrontal Cortex Psychiatry Schizophrenia Schizophrenia - drug therapy Schizophrenia - genetics
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