Targeting PHGDH upregulation reduces glutathione levels and re-sensitizes resistant NRAS mutant melanoma to MEK inhibition

Melanomas frequently harbor activating NRAS mutations leading to activation of MEK-ERK1/2 signaling; however, clinical efficacy of inhibitors to this pathway are limited by resistance. Tumors re-wire metabolic pathways in response to stress signals such as targeted inhibitors and drug resistance, bu...

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Veröffentlicht in:	Journal of investigative dermatology 2020-05, Vol.140 (11), p.2242-2252.e7
Hauptverfasser:	Nguyen, Mai Q., Teh, Jessica L.F., Purwin, Timothy J., Chervoneva, Inna, Davies, Michael A., Nathanson, Katherine L., Cheng, Phil F., Levesque, Mitchell P., Dummer, Reinhard, Aplin, Andrew E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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