An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation

Histone H3 lysine 36 methylation (H3K36me) is a conserved histone modification associated with transcription and DNA repair. Although the effects of H3K36 methylation have been studied, the genome-wide dynamics of H3K36me deposition and removal are not known. We established rapid and reversible opto...

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Veröffentlicht in:	Genome research 2020-11, Vol.30 (11), p.1605-1617
Hauptverfasser:	Lerner, Andrew M, Hepperla, Austin J, Keele, Gregory R, Meriesh, Hashem A, Yumerefendi, Hayretin, Restrepo, David, Zimmerman, Seth, Bear, James E, Kuhlman, Brian, Davis, Ian J, Strahl, Brian D
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Demethylation DNA methylation DNA repair Genome, Fungal Genomes Histone Code Histone Demethylases - metabolism Histone H3 Histones Histones - chemistry Histones - metabolism Localization Lysine Lysine - metabolism Methylation Methyltransferase Methyltransferases - metabolism Models, Statistical Optogenetics Repressor Proteins - metabolism Ribonucleic acid RNA Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Transcription Transcription, Genetic
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