Primary ectopic Merkel cell carcinoma without skin involvement—report of a case with prolonged survival
Abstract Merkel cell carcinoma is a rare neuroendocrine malignancy that arises from the dermis, in cases of immunocompromised, middle-aged patients or on skin exposed to sunlight. It only rarely presents in extra-cutaneous locations. We present the case of a 63-year-old female with a mass in the adi...
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Veröffentlicht in: | Journal of surgical case reports 2020-10, Vol.2020 (10) |
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creator | Effraimidou, Eleni Kofina, Konstantinia Giatromanolaki, Alexandra Chatzipantelis, Paschalis Karanikas, Michael Lyratzopoulos, Nicolaos |
description | Abstract
Merkel cell carcinoma is a rare neuroendocrine malignancy that arises from the dermis, in cases of immunocompromised, middle-aged patients or on skin exposed to sunlight. It only rarely presents in extra-cutaneous locations. We present the case of a 63-year-old female with a mass in the adipose tissue of the upper arm, without skin involvement and concurrent axillary lymph node enlargement. She was treated with wide excision and lymph node dissection; pathology led to the diagnosis of Merkel cell carcinoma, and she was subsequently submitted to adjuvant radiotherapy. No signs of recurrence are present 8 years postoperatively. Primary Merkel cell carcinoma can rarely be located in the adipose tissue without skin involvement. In cases of high suspicion, preoperative MRI scan can show the extent of the lesion, as well as lymph metastases. |
doi_str_mv | 10.1093/jscr/rjaa390 |
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Merkel cell carcinoma is a rare neuroendocrine malignancy that arises from the dermis, in cases of immunocompromised, middle-aged patients or on skin exposed to sunlight. It only rarely presents in extra-cutaneous locations. We present the case of a 63-year-old female with a mass in the adipose tissue of the upper arm, without skin involvement and concurrent axillary lymph node enlargement. She was treated with wide excision and lymph node dissection; pathology led to the diagnosis of Merkel cell carcinoma, and she was subsequently submitted to adjuvant radiotherapy. No signs of recurrence are present 8 years postoperatively. Primary Merkel cell carcinoma can rarely be located in the adipose tissue without skin involvement. In cases of high suspicion, preoperative MRI scan can show the extent of the lesion, as well as lymph metastases.</description><identifier>ISSN: 2042-8812</identifier><identifier>EISSN: 2042-8812</identifier><identifier>DOI: 10.1093/jscr/rjaa390</identifier><identifier>PMID: 33163153</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Case Report</subject><ispartof>Journal of surgical case reports, 2020-10, Vol.2020 (10)</ispartof><rights>Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c317t-4a17102e4f6c10a1ad4c478f30a724483682417d2be1315b519ad9207787fffb3</cites><orcidid>0000-0002-8052-2807</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605217/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605217/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1604,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Effraimidou, Eleni</creatorcontrib><creatorcontrib>Kofina, Konstantinia</creatorcontrib><creatorcontrib>Giatromanolaki, Alexandra</creatorcontrib><creatorcontrib>Chatzipantelis, Paschalis</creatorcontrib><creatorcontrib>Karanikas, Michael</creatorcontrib><creatorcontrib>Lyratzopoulos, Nicolaos</creatorcontrib><title>Primary ectopic Merkel cell carcinoma without skin involvement—report of a case with prolonged survival</title><title>Journal of surgical case reports</title><description>Abstract
Merkel cell carcinoma is a rare neuroendocrine malignancy that arises from the dermis, in cases of immunocompromised, middle-aged patients or on skin exposed to sunlight. It only rarely presents in extra-cutaneous locations. We present the case of a 63-year-old female with a mass in the adipose tissue of the upper arm, without skin involvement and concurrent axillary lymph node enlargement. She was treated with wide excision and lymph node dissection; pathology led to the diagnosis of Merkel cell carcinoma, and she was subsequently submitted to adjuvant radiotherapy. No signs of recurrence are present 8 years postoperatively. Primary Merkel cell carcinoma can rarely be located in the adipose tissue without skin involvement. In cases of high suspicion, preoperative MRI scan can show the extent of the lesion, as well as lymph metastases.</description><subject>Case Report</subject><issn>2042-8812</issn><issn>2042-8812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9UMtOwzAQtBCIVqU3PsA3LoR6bTdOLkio4iUVwQHOkeM4rdskjuwkiBsfwRfyJaSkQnBhD7sr7cxoZxA6BXIBJGazjVdu5jZSspgcoDElnAZRBPTw1z5CU-83pC8eA0ThMRoxBiGDORsj8-RMKd0b1qqxtVH4QbutLrDSRd-kU6aypcSvplnbtsF-aypsqs4WnS511Xy-fzhdW9dgm2PZE7z-xuLa2cJWK51h37rOdLI4QUe5LLye7ucEvdxcPy_uguXj7f3iahkoBqIJuAQBhGqehwqIBJlxxUWUMyIF5TxiYUQ5iIymGnoL6RximcWUCBGJPM9TNkGXg27dpqXOVP-lk0VSDz4TK03y91KZdbKyXSJCMqcgeoHzQUA5673T-Q8XSLJLPdmlnuxT7-FnA9y29f_IL-DJhrM</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Effraimidou, Eleni</creator><creator>Kofina, Konstantinia</creator><creator>Giatromanolaki, Alexandra</creator><creator>Chatzipantelis, Paschalis</creator><creator>Karanikas, Michael</creator><creator>Lyratzopoulos, Nicolaos</creator><general>Oxford University Press</general><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8052-2807</orcidid></search><sort><creationdate>20201001</creationdate><title>Primary ectopic Merkel cell carcinoma without skin involvement—report of a case with prolonged survival</title><author>Effraimidou, Eleni ; Kofina, Konstantinia ; Giatromanolaki, Alexandra ; Chatzipantelis, Paschalis ; Karanikas, Michael ; Lyratzopoulos, Nicolaos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-4a17102e4f6c10a1ad4c478f30a724483682417d2be1315b519ad9207787fffb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Case Report</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Effraimidou, Eleni</creatorcontrib><creatorcontrib>Kofina, Konstantinia</creatorcontrib><creatorcontrib>Giatromanolaki, Alexandra</creatorcontrib><creatorcontrib>Chatzipantelis, Paschalis</creatorcontrib><creatorcontrib>Karanikas, Michael</creatorcontrib><creatorcontrib>Lyratzopoulos, Nicolaos</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of surgical case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Effraimidou, Eleni</au><au>Kofina, Konstantinia</au><au>Giatromanolaki, Alexandra</au><au>Chatzipantelis, Paschalis</au><au>Karanikas, Michael</au><au>Lyratzopoulos, Nicolaos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary ectopic Merkel cell carcinoma without skin involvement—report of a case with prolonged survival</atitle><jtitle>Journal of surgical case reports</jtitle><date>2020-10-01</date><risdate>2020</risdate><volume>2020</volume><issue>10</issue><issn>2042-8812</issn><eissn>2042-8812</eissn><abstract>Abstract
Merkel cell carcinoma is a rare neuroendocrine malignancy that arises from the dermis, in cases of immunocompromised, middle-aged patients or on skin exposed to sunlight. It only rarely presents in extra-cutaneous locations. We present the case of a 63-year-old female with a mass in the adipose tissue of the upper arm, without skin involvement and concurrent axillary lymph node enlargement. She was treated with wide excision and lymph node dissection; pathology led to the diagnosis of Merkel cell carcinoma, and she was subsequently submitted to adjuvant radiotherapy. No signs of recurrence are present 8 years postoperatively. Primary Merkel cell carcinoma can rarely be located in the adipose tissue without skin involvement. In cases of high suspicion, preoperative MRI scan can show the extent of the lesion, as well as lymph metastases.</abstract><pub>Oxford University Press</pub><pmid>33163153</pmid><doi>10.1093/jscr/rjaa390</doi><orcidid>https://orcid.org/0000-0002-8052-2807</orcidid><oa>free_for_read</oa></addata></record> |
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title | Primary ectopic Merkel cell carcinoma without skin involvement—report of a case with prolonged survival |
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