COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms
Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and poses a huge threat to human health. Besides common respiratory symptoms, some patients with COVID-19 experience gastrointestinal symptoms, such as d...
Gespeichert in:
| Veröffentlicht in: | Signal transduction and targeted therapy 2020-11, Vol.5 (1), p.256, Article 256 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 256 |
| container_title | Signal transduction and targeted therapy |
| container_volume | 5 |
| creator | Zhong, Peijie Xu, Jing Yang, Dong Shen, Yue Wang, Lu Feng, Yun Du, Chunling Song, Yuanlin Wu, Chaomin Hu, Xianglin Sun, Yangbai |
| description | Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and poses a huge threat to human health. Besides common respiratory symptoms, some patients with COVID-19 experience gastrointestinal symptoms, such as diarrhea, nausea, vomiting, and loss of appetite. SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2 (ACE2) and there is increasing evidence of a possible fecal–oral transmission route. In addition, there exist multiple abnormalities in liver enzymes. COVID-19-related liver injury may be due to drug-induced liver injury, systemic inflammatory reaction, and hypoxia–ischemia reperfusion injury. The direct toxic attack of SARS-CoV-2 on the liver is still questionable. This review highlights the manifestations and potential mechanisms of gastrointestinal and hepatic injuries in COVID-19 to raise awareness of digestive system injury in COVID-19. |
| doi_str_mv | 10.1038/s41392-020-00373-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7605138</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471529864</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-a1ee87237fe65ccb3055aa5b714892b633ca6398115b384c6697667753fb0533</originalsourceid><addsrcrecordid>eNp9UV1LwzAUDaK4Mf0DPkjB52jS2yStD4LMr4GwF_E1pFm6ZXTpTNrB_r1x1TlffMol5-Pew0HogpJrSiC_CRmFIsUkJZgQEIDFERqmhBUYOLDjg3mAzkNYEkIoByFYdooGAFHMCxgiNZ6-Tx4wLbAKodFWtWaWzFVofWNda0JrnaoT5WZJbTfGJ9YtO7-9TXRtndURqoxqO2_CjrNuWuNaG79XRi-Us2EVztBJpepgzr_fEXp7enwbv-DX6fNkfP-KNctIixU1JhcpiMpwpnUJhDGlWClolhdpyQG04lDklLIS8kxzXgjOYx6oSsIARuiut1135crMdLzDq1quvV0pv5WNsvIv4uxCzpuNFJwwCnk0uPo28M1HF5PLZdP5mD7INBOUpUXOs8hKe5b2TQjeVPsNlMivYmRfjIzFyF0xUkTR5eFte8lPDZEAPSFEyM2N_939j-0n5f6Zdg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471529864</pqid></control><display><type>article</type><title>COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Springer Nature OA Free Journals</source><creator>Zhong, Peijie ; Xu, Jing ; Yang, Dong ; Shen, Yue ; Wang, Lu ; Feng, Yun ; Du, Chunling ; Song, Yuanlin ; Wu, Chaomin ; Hu, Xianglin ; Sun, Yangbai</creator><creatorcontrib>Zhong, Peijie ; Xu, Jing ; Yang, Dong ; Shen, Yue ; Wang, Lu ; Feng, Yun ; Du, Chunling ; Song, Yuanlin ; Wu, Chaomin ; Hu, Xianglin ; Sun, Yangbai</creatorcontrib><description>Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and poses a huge threat to human health. Besides common respiratory symptoms, some patients with COVID-19 experience gastrointestinal symptoms, such as diarrhea, nausea, vomiting, and loss of appetite. SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2 (ACE2) and there is increasing evidence of a possible fecal–oral transmission route. In addition, there exist multiple abnormalities in liver enzymes. COVID-19-related liver injury may be due to drug-induced liver injury, systemic inflammatory reaction, and hypoxia–ischemia reperfusion injury. The direct toxic attack of SARS-CoV-2 on the liver is still questionable. This review highlights the manifestations and potential mechanisms of gastrointestinal and hepatic injuries in COVID-19 to raise awareness of digestive system injury in COVID-19.</description><identifier>ISSN: 2059-3635</identifier><identifier>ISSN: 2095-9907</identifier><identifier>EISSN: 2059-3635</identifier><identifier>DOI: 10.1038/s41392-020-00373-7</identifier><identifier>PMID: 33139693</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4020/1503 ; 692/699/255 ; Angiotensin-Converting Enzyme 2 ; Cancer Research ; Cell Biology ; Chemical and Drug Induced Liver Injury - epidemiology ; Chemical and Drug Induced Liver Injury - genetics ; Chemical and Drug Induced Liver Injury - pathology ; Chemical and Drug Induced Liver Injury - virology ; Coronavirus Infections - epidemiology ; Coronavirus Infections - genetics ; Coronavirus Infections - pathology ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Disease transmission ; Feces - virology ; Gastrointestinal Diseases - complications ; Gastrointestinal Diseases - epidemiology ; Gastrointestinal Diseases - genetics ; Gastrointestinal Diseases - virology ; Gastrointestinal Tract - injuries ; Gastrointestinal Tract - pathology ; Gastrointestinal Tract - virology ; Humans ; Internal Medicine ; Liver ; Liver - physiopathology ; Liver - virology ; Liver Diseases - epidemiology ; Liver Diseases - genetics ; Liver Diseases - pathology ; Liver Diseases - virology ; Medicine ; Medicine & Public Health ; Oncology ; Pandemics ; Pathology ; Peptidyl-Dipeptidase A - genetics ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - genetics ; Pneumonia, Viral - pathology ; Pneumonia, Viral - virology ; Review ; Review Article ; Severe acute respiratory syndrome coronavirus 2</subject><ispartof>Signal transduction and targeted therapy, 2020-11, Vol.5 (1), p.256, Article 256</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-a1ee87237fe65ccb3055aa5b714892b633ca6398115b384c6697667753fb0533</citedby><cites>FETCH-LOGICAL-c540t-a1ee87237fe65ccb3055aa5b714892b633ca6398115b384c6697667753fb0533</cites><orcidid>0000-0002-7133-9867</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605138/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605138/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33139693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhong, Peijie</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Yang, Dong</creatorcontrib><creatorcontrib>Shen, Yue</creatorcontrib><creatorcontrib>Wang, Lu</creatorcontrib><creatorcontrib>Feng, Yun</creatorcontrib><creatorcontrib>Du, Chunling</creatorcontrib><creatorcontrib>Song, Yuanlin</creatorcontrib><creatorcontrib>Wu, Chaomin</creatorcontrib><creatorcontrib>Hu, Xianglin</creatorcontrib><creatorcontrib>Sun, Yangbai</creatorcontrib><title>COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms</title><title>Signal transduction and targeted therapy</title><addtitle>Sig Transduct Target Ther</addtitle><addtitle>Signal Transduct Target Ther</addtitle><description>Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and poses a huge threat to human health. Besides common respiratory symptoms, some patients with COVID-19 experience gastrointestinal symptoms, such as diarrhea, nausea, vomiting, and loss of appetite. SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2 (ACE2) and there is increasing evidence of a possible fecal–oral transmission route. In addition, there exist multiple abnormalities in liver enzymes. COVID-19-related liver injury may be due to drug-induced liver injury, systemic inflammatory reaction, and hypoxia–ischemia reperfusion injury. The direct toxic attack of SARS-CoV-2 on the liver is still questionable. This review highlights the manifestations and potential mechanisms of gastrointestinal and hepatic injuries in COVID-19 to raise awareness of digestive system injury in COVID-19.</description><subject>692/4020/1503</subject><subject>692/699/255</subject><subject>Angiotensin-Converting Enzyme 2</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Chemical and Drug Induced Liver Injury - epidemiology</subject><subject>Chemical and Drug Induced Liver Injury - genetics</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Chemical and Drug Induced Liver Injury - virology</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronavirus Infections - genetics</subject><subject>Coronavirus Infections - pathology</subject><subject>Coronavirus Infections - virology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Disease transmission</subject><subject>Feces - virology</subject><subject>Gastrointestinal Diseases - complications</subject><subject>Gastrointestinal Diseases - epidemiology</subject><subject>Gastrointestinal Diseases - genetics</subject><subject>Gastrointestinal Diseases - virology</subject><subject>Gastrointestinal Tract - injuries</subject><subject>Gastrointestinal Tract - pathology</subject><subject>Gastrointestinal Tract - virology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Liver</subject><subject>Liver - physiopathology</subject><subject>Liver - virology</subject><subject>Liver Diseases - epidemiology</subject><subject>Liver Diseases - genetics</subject><subject>Liver Diseases - pathology</subject><subject>Liver Diseases - virology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Pandemics</subject><subject>Pathology</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Pneumonia, Viral - genetics</subject><subject>Pneumonia, Viral - pathology</subject><subject>Pneumonia, Viral - virology</subject><subject>Review</subject><subject>Review Article</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><issn>2059-3635</issn><issn>2095-9907</issn><issn>2059-3635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9UV1LwzAUDaK4Mf0DPkjB52jS2yStD4LMr4GwF_E1pFm6ZXTpTNrB_r1x1TlffMol5-Pew0HogpJrSiC_CRmFIsUkJZgQEIDFERqmhBUYOLDjg3mAzkNYEkIoByFYdooGAFHMCxgiNZ6-Tx4wLbAKodFWtWaWzFVofWNda0JrnaoT5WZJbTfGJ9YtO7-9TXRtndURqoxqO2_CjrNuWuNaG79XRi-Us2EVztBJpepgzr_fEXp7enwbv-DX6fNkfP-KNctIixU1JhcpiMpwpnUJhDGlWClolhdpyQG04lDklLIS8kxzXgjOYx6oSsIARuiut1135crMdLzDq1quvV0pv5WNsvIv4uxCzpuNFJwwCnk0uPo28M1HF5PLZdP5mD7INBOUpUXOs8hKe5b2TQjeVPsNlMivYmRfjIzFyF0xUkTR5eFte8lPDZEAPSFEyM2N_939j-0n5f6Zdg</recordid><startdate>20201102</startdate><enddate>20201102</enddate><creator>Zhong, Peijie</creator><creator>Xu, Jing</creator><creator>Yang, Dong</creator><creator>Shen, Yue</creator><creator>Wang, Lu</creator><creator>Feng, Yun</creator><creator>Du, Chunling</creator><creator>Song, Yuanlin</creator><creator>Wu, Chaomin</creator><creator>Hu, Xianglin</creator><creator>Sun, Yangbai</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7133-9867</orcidid></search><sort><creationdate>20201102</creationdate><title>COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms</title><author>Zhong, Peijie ; Xu, Jing ; Yang, Dong ; Shen, Yue ; Wang, Lu ; Feng, Yun ; Du, Chunling ; Song, Yuanlin ; Wu, Chaomin ; Hu, Xianglin ; Sun, Yangbai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-a1ee87237fe65ccb3055aa5b714892b633ca6398115b384c6697667753fb0533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/4020/1503</topic><topic>692/699/255</topic><topic>Angiotensin-Converting Enzyme 2</topic><topic>Cancer Research</topic><topic>Cell Biology</topic><topic>Chemical and Drug Induced Liver Injury - epidemiology</topic><topic>Chemical and Drug Induced Liver Injury - genetics</topic><topic>Chemical and Drug Induced Liver Injury - pathology</topic><topic>Chemical and Drug Induced Liver Injury - virology</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronavirus Infections - genetics</topic><topic>Coronavirus Infections - pathology</topic><topic>Coronavirus Infections - virology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Disease transmission</topic><topic>Feces - virology</topic><topic>Gastrointestinal Diseases - complications</topic><topic>Gastrointestinal Diseases - epidemiology</topic><topic>Gastrointestinal Diseases - genetics</topic><topic>Gastrointestinal Diseases - virology</topic><topic>Gastrointestinal Tract - injuries</topic><topic>Gastrointestinal Tract - pathology</topic><topic>Gastrointestinal Tract - virology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Liver</topic><topic>Liver - physiopathology</topic><topic>Liver - virology</topic><topic>Liver Diseases - epidemiology</topic><topic>Liver Diseases - genetics</topic><topic>Liver Diseases - pathology</topic><topic>Liver Diseases - virology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Pandemics</topic><topic>Pathology</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Pneumonia, Viral - epidemiology</topic><topic>Pneumonia, Viral - genetics</topic><topic>Pneumonia, Viral - pathology</topic><topic>Pneumonia, Viral - virology</topic><topic>Review</topic><topic>Review Article</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhong, Peijie</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Yang, Dong</creatorcontrib><creatorcontrib>Shen, Yue</creatorcontrib><creatorcontrib>Wang, Lu</creatorcontrib><creatorcontrib>Feng, Yun</creatorcontrib><creatorcontrib>Du, Chunling</creatorcontrib><creatorcontrib>Song, Yuanlin</creatorcontrib><creatorcontrib>Wu, Chaomin</creatorcontrib><creatorcontrib>Hu, Xianglin</creatorcontrib><creatorcontrib>Sun, Yangbai</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Signal transduction and targeted therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, Peijie</au><au>Xu, Jing</au><au>Yang, Dong</au><au>Shen, Yue</au><au>Wang, Lu</au><au>Feng, Yun</au><au>Du, Chunling</au><au>Song, Yuanlin</au><au>Wu, Chaomin</au><au>Hu, Xianglin</au><au>Sun, Yangbai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms</atitle><jtitle>Signal transduction and targeted therapy</jtitle><stitle>Sig Transduct Target Ther</stitle><addtitle>Signal Transduct Target Ther</addtitle><date>2020-11-02</date><risdate>2020</risdate><volume>5</volume><issue>1</issue><spage>256</spage><pages>256-</pages><artnum>256</artnum><issn>2059-3635</issn><issn>2095-9907</issn><eissn>2059-3635</eissn><abstract>Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and poses a huge threat to human health. Besides common respiratory symptoms, some patients with COVID-19 experience gastrointestinal symptoms, such as diarrhea, nausea, vomiting, and loss of appetite. SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2 (ACE2) and there is increasing evidence of a possible fecal–oral transmission route. In addition, there exist multiple abnormalities in liver enzymes. COVID-19-related liver injury may be due to drug-induced liver injury, systemic inflammatory reaction, and hypoxia–ischemia reperfusion injury. The direct toxic attack of SARS-CoV-2 on the liver is still questionable. This review highlights the manifestations and potential mechanisms of gastrointestinal and hepatic injuries in COVID-19 to raise awareness of digestive system injury in COVID-19.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33139693</pmid><doi>10.1038/s41392-020-00373-7</doi><orcidid>https://orcid.org/0000-0002-7133-9867</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2059-3635 |
| ispartof | Signal transduction and targeted therapy, 2020-11, Vol.5 (1), p.256, Article 256 |
| issn | 2059-3635 2095-9907 2059-3635 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7605138 |
| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Springer Nature OA Free Journals |
| subjects | 692/4020/1503 692/699/255 Angiotensin-Converting Enzyme 2 Cancer Research Cell Biology Chemical and Drug Induced Liver Injury - epidemiology Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - virology Coronavirus Infections - epidemiology Coronavirus Infections - genetics Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 Disease transmission Feces - virology Gastrointestinal Diseases - complications Gastrointestinal Diseases - epidemiology Gastrointestinal Diseases - genetics Gastrointestinal Diseases - virology Gastrointestinal Tract - injuries Gastrointestinal Tract - pathology Gastrointestinal Tract - virology Humans Internal Medicine Liver Liver - physiopathology Liver - virology Liver Diseases - epidemiology Liver Diseases - genetics Liver Diseases - pathology Liver Diseases - virology Medicine Medicine & Public Health Oncology Pandemics Pathology Peptidyl-Dipeptidase A - genetics Pneumonia, Viral - epidemiology Pneumonia, Viral - genetics Pneumonia, Viral - pathology Pneumonia, Viral - virology Review Review Article Severe acute respiratory syndrome coronavirus 2 |
| title | COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T04%3A26%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=COVID-19-associated%20gastrointestinal%20and%20liver%20injury:%20clinical%20features%20and%20potential%20mechanisms&rft.jtitle=Signal%20transduction%20and%20targeted%20therapy&rft.au=Zhong,%20Peijie&rft.date=2020-11-02&rft.volume=5&rft.issue=1&rft.spage=256&rft.pages=256-&rft.artnum=256&rft.issn=2059-3635&rft.eissn=2059-3635&rft_id=info:doi/10.1038/s41392-020-00373-7&rft_dat=%3Cproquest_pubme%3E2471529864%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471529864&rft_id=info:pmid/33139693&rfr_iscdi=true |