Favipiravir at high doses has potent antiviral activity in SARS-CoV-2–infected hamsters, whereas hydroxychloroquine lacks activity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the globe after its emergence in Wuhan in December 2019. With no specific therapeutic and prophylactic options available, the virus has infected millions of people of which more than half a million succumbed to the vi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-10, Vol.117 (43), p.26955-26965
Hauptverfasser:	Kaptein, Suzanne J. F., Jacobs, Sofie, Langendries, Lana, Seldeslachts, Laura, ter Horst, Sebastiaan, Liesenborghs, Laurens, Hens, Bart, Vergote, Valentijn, Heylen, Elisabeth, Barthelemy, Karine, Maas, Elke, De Keyzer, Carolien, Bervoets, Lindsey, Rymenants, Jasper, Van Buyten, Tina, Zhang, Xin, Abdelnabi, Rana, Pang, Juanita, Williams, Rachel, Thibaut, Hendrik Jan, Dallmeier, Kai, Boudewijns, Robbert, Wouters, Jens, Augustijns, Patrick, Verougstraete, Nick, Cawthorne, Christopher, Breuer, Judith, Solas, Caroline, Weynand, Birgit, Annaert, Pieter, Spriet, Isabel, Velde, Greetje Vande, Neyts, Johan, Rocha-Pereira, Joana, Delang, Leen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacokinetics Amides - therapeutic use Animal models Animals Antiviral activity Antiviral agents Antiviral Agents - therapeutic use Azithromycin Betacoronavirus - drug effects Biocompatibility Biological Sciences Chlorocebus aethiops Clinical trials Coronavirus Infections - drug therapy Coronavirus Infections - virology Coronaviruses COVID-19 COVID-19 Drug Treatment Cricetinae Disease Models, Animal Disease transmission Disease Transmission, Infectious - prevention & control Dose-Response Relationship, Drug Drug dosages Drug Evaluation, Preclinical Female Hamsters Health services Histopathology Hydroxychloroquine Hydroxychloroquine - pharmacokinetics Hydroxychloroquine - therapeutic use Infections Lung - drug effects Lung - pathology Lung - virology Lungs Pharmacokinetics Prophylaxis Pyrazines - pharmacokinetics Pyrazines - therapeutic use Respiratory diseases SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Treatment Outcome Vero Cells Viral diseases Viral Load - drug effects Viruses
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