Methane-Rich Saline Alleviates CA/CPR Brain Injury by Inhibiting Oxidative Stress, Microglial Activation-Induced Inflammatory Responses, and ER Stress-Mediated Apoptosis

Brain injury induced by cardiac arrest/cardiopulmonary resuscitation (CA/CPR) is the leading cause of death among patients who have recovery of spontaneous circulation (ROSC). Inflammatory response, apoptosis, and oxidative stress are proven pathological mechanisms implicated in neuronal damage. Met...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-13
Hauptverfasser:	Zhang, Jingyao, Liu, Chang, Jia, Yifan, Ren, Jie, Liu, Tong, Wang, Cong, Liu, Sinan, Cui, Ruixia, Tong, Yingmu
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Apoptosis - drug effects Blood Pressure - drug effects Brain Brain research CA1 Region, Hippocampal - pathology Cardiopulmonary Resuscitation Chromatography CPR Cytokines Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Health sciences Heart Arrest - complications Heart Arrest - physiopathology Heart Rate - drug effects Inflammation - pathology Injuries Ischemia Kinases Laboratory animals Male Methane Methane - chemistry Microglia - drug effects Microglia - pathology Models, Biological Neurons Neurons - pathology Nitric oxide Ostomy Oxidative stress Oxidative Stress - drug effects Proteins Rats, Sprague-Dawley Return of Spontaneous Circulation Saline Solution - pharmacology Transcription factors Traumatic brain injury Tumor necrosis factor-TNF Ventilators
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