Preparation and characterization of amnion hydrogel and its synergistic effect with adipose derived stem cells towards IL1β activated chondrocytes

Inflammation leads to chondrocyte senescence and cartilage degeneration, resulting in osteoarthritis (OA). Adipose‐derived stem cells (ADSCs) exert paracrine effects protecting chondrocytes from degenerative changes. However, the lack of optimum delivery systems for ADSCs limits its use in the clini...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.18751-18751, Article 18751
Hauptverfasser:	Bhattacharjee, Maumita, Ivirico, Jorge L. Escobar, Kan, Ho-Man, Bordett, Rosalie, Pandey, Rishikesh, Otsuka, Takayoshi, Nair, Lakshmi S., Laurencin, Cato T.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/2074 639/301 692/699 Adipocytes - cytology Amnion Amnion - chemistry Animals Cartilage diseases Cell Proliferation - drug effects Cell viability Cells, Cultured Chondrocytes Chondrocytes - cytology Chondrocytes - drug effects Cytokines - pharmacology Degeneration Extracellular matrix Female Humanities and Social Sciences Humans Hydrogels Hydrogels - chemistry IL-1β Inflammation Inflammation - metabolism Interleukin 1 Interleukin-1beta - pharmacology Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects multidisciplinary Nitric Oxide - metabolism Osteoarthritis Paracrine signalling Rats Science Science (multidisciplinary) Senescence Signal transduction Stem cells Stem Cells - cytology Stem Cells - drug effects Synergistic effect Wnt protein β-Catenin
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