Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients
The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear. This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD...
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| Veröffentlicht in: | Nutrients 2020-10, Vol.12 (10), p.3187 |
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| creator | Toida, Tatsunori Toida, Reiko Ebihara, Shou Takahashi, Risa Komatsu, Hiroyuki Uezono, Shigehiro Sato, Yuji Fujimoto, Shouichi |
| description | The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear.
This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, |
| doi_str_mv | 10.3390/nu12103187 |
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This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45-59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox's regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders.
Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox's regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant.
Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12103187</identifier><identifier>PMID: 33086501</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aged ; Aged, 80 and over ; Angina pectoris ; Bioelectricity ; Biomarkers - blood ; Body Composition ; Body Fluids - metabolism ; Body mass index ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Cause of Death ; Copper ; Diabetes ; Female ; Follow-Up Studies ; Geriatrics ; Heart attacks ; Heart failure ; Hemodialysis ; Hospitals ; Humans ; Internal medicine ; Kidney diseases ; Laboratories ; Male ; Markers ; Metabolism ; Middle Aged ; Mortality ; Normal distribution ; Nutrition ; Nutrition Assessment ; Nutritional status ; Parenteral nutrition ; Patients ; Prospective Studies ; Regression analysis ; Renal Dialysis - adverse effects ; Spectrum analysis ; Trace elements ; Variance analysis ; Zinc ; Zinc - blood ; Zinc - deficiency</subject><ispartof>Nutrients, 2020-10, Vol.12 (10), p.3187</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-62714ad5569a347448665e6b914a459a46c903919ef62355b6195dd9e81282ae3</citedby><cites>FETCH-LOGICAL-c450t-62714ad5569a347448665e6b914a459a46c903919ef62355b6195dd9e81282ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603268/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603268/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33086501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toida, Tatsunori</creatorcontrib><creatorcontrib>Toida, Reiko</creatorcontrib><creatorcontrib>Ebihara, Shou</creatorcontrib><creatorcontrib>Takahashi, Risa</creatorcontrib><creatorcontrib>Komatsu, Hiroyuki</creatorcontrib><creatorcontrib>Uezono, Shigehiro</creatorcontrib><creatorcontrib>Sato, Yuji</creatorcontrib><creatorcontrib>Fujimoto, Shouichi</creatorcontrib><title>Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear.
This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45-59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox's regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders.
Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox's regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant.
Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angina pectoris</subject><subject>Bioelectricity</subject><subject>Biomarkers - blood</subject><subject>Body Composition</subject><subject>Body Fluids - metabolism</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cause of Death</subject><subject>Copper</subject><subject>Diabetes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Geriatrics</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Markers</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Normal distribution</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Nutritional status</subject><subject>Parenteral nutrition</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Renal Dialysis - adverse effects</subject><subject>Spectrum analysis</subject><subject>Trace elements</subject><subject>Variance analysis</subject><subject>Zinc</subject><subject>Zinc - blood</subject><subject>Zinc - deficiency</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkVtLXDEUhUOpVBl98QeUQF9KYTT3c_JS0MEbDFiovvgSMsmeGjknmSbnWOffG-_WvOyw98dae7MQ2qVkj3NN9uNIGSWcts0ntMVIw6ZKCf753X8T7ZRyQx5eQxrFv6BNzkmrJKFbKB-UklywQ0gRL2D4BxDxb8hjj69CdHgOt9AVbKPHsy7E4GyHz6KHO5wyHq4BHya_xrPUr1IJjyIhVsAFD3HAp9AnH2y3LqHgX9WkNss22ljarsDOc52gy-Oji9npdH5-cjY7mE-dkGSYKtZQYb2USlsuGiFapSSoha5dIbUVymnCNdWwVIxLuVBUS-81tJS1zAKfoJ9Puqtx0YN31Tvbzqxy6G1em2SD-X8Sw7X5k25Nowhnqq0C358Fcvo7QhlMH4qDrrMR0lgME5KrtqXVfoK-fUBv0phjPc8wyaUgnEhRqR9PlMuplAzL12UoMQ9pmrc0K_z1_fqv6Et2_B6UEpm_</recordid><startdate>20201019</startdate><enddate>20201019</enddate><creator>Toida, Tatsunori</creator><creator>Toida, Reiko</creator><creator>Ebihara, Shou</creator><creator>Takahashi, Risa</creator><creator>Komatsu, Hiroyuki</creator><creator>Uezono, Shigehiro</creator><creator>Sato, Yuji</creator><creator>Fujimoto, Shouichi</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201019</creationdate><title>Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients</title><author>Toida, Tatsunori ; 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This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45-59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox's regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders.
Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox's regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant.
Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33086501</pmid><doi>10.3390/nu12103187</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Angina pectoris Bioelectricity Biomarkers - blood Body Composition Body Fluids - metabolism Body mass index Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Cause of Death Copper Diabetes Female Follow-Up Studies Geriatrics Heart attacks Heart failure Hemodialysis Hospitals Humans Internal medicine Kidney diseases Laboratories Male Markers Metabolism Middle Aged Mortality Normal distribution Nutrition Nutrition Assessment Nutritional status Parenteral nutrition Patients Prospective Studies Regression analysis Renal Dialysis - adverse effects Spectrum analysis Trace elements Variance analysis Zinc Zinc - blood Zinc - deficiency |
| title | Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients |
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