Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant
Poly(L-lactic) acid (PLLA) is among the most promising polymers for bone fixation, repair, and tissue engineering due to its biodegradability and relatively good mechanical strength. Despite these beneficial characteristics, its poor bioactivity often requires incorporation of bioactive ceramic mate...
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| Veröffentlicht in: | Polymers 2020-10, Vol.12 (10), p.2390 |
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| creator | Kim, Sae-Mi Kang, In-Gu Cheon, Kwang-Hee Jang, Tae-Sik Kim, Hyoun-Ee Jung, Hyun-Do Kang, Min-Ho |
| description | Poly(L-lactic) acid (PLLA) is among the most promising polymers for bone fixation, repair, and tissue engineering due to its biodegradability and relatively good mechanical strength. Despite these beneficial characteristics, its poor bioactivity often requires incorporation of bioactive ceramic materials. A bioresorbable composite made of PLLA and hydroxyapatite (HA) may improve biocompatibility but typically causes deterioration in mechanical properties, and bioactive coatings inevitably carry a risk of coating delamination. Therefore, in this study, we embedded micropatterned HA on the surface of PLLA to improve bioactivity while eliminating the risk of HA delamination. An HA pattern was successfully embedded in a PLLA matrix without degeneration of the matrix’s mechanical properties, thanks to a transfer technique involving conversion of Mg to HA. Furthermore, patterned HA/PLLA’s biological response outperformed that of pure PLLA. These results confirm patterned HA/PLLA as a candidate for wide acceptance in biodegradable load-bearing implant applications. |
| doi_str_mv | 10.3390/polym12102390 |
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Despite these beneficial characteristics, its poor bioactivity often requires incorporation of bioactive ceramic materials. A bioresorbable composite made of PLLA and hydroxyapatite (HA) may improve biocompatibility but typically causes deterioration in mechanical properties, and bioactive coatings inevitably carry a risk of coating delamination. Therefore, in this study, we embedded micropatterned HA on the surface of PLLA to improve bioactivity while eliminating the risk of HA delamination. An HA pattern was successfully embedded in a PLLA matrix without degeneration of the matrix’s mechanical properties, thanks to a transfer technique involving conversion of Mg to HA. Furthermore, patterned HA/PLLA’s biological response outperformed that of pure PLLA. These results confirm patterned HA/PLLA as a candidate for wide acceptance in biodegradable load-bearing implant applications.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym12102390</identifier><identifier>PMID: 33080777</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Biocompatibility ; Biodegradability ; Biological activity ; Biomedical materials ; Cell growth ; Ceramic glazes ; Contact angle ; Degeneration ; Delamination ; Hydroxyapatite ; Mechanical properties ; Micropatterning ; Morphology ; Polylactic acid ; Protective coatings ; Scanning electron microscopy ; Silicon wafers ; Tensile strength ; Tension tests ; Tissue engineering</subject><ispartof>Polymers, 2020-10, Vol.12 (10), p.2390</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-7c695999d2ce22cf17230c17ebc9729ff7a43b3a15fd9e9098caee1ebf9821fd3</citedby><cites>FETCH-LOGICAL-c436t-7c695999d2ce22cf17230c17ebc9729ff7a43b3a15fd9e9098caee1ebf9821fd3</cites><orcidid>0000-0001-8632-7431</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603062/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603062/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Kim, Sae-Mi</creatorcontrib><creatorcontrib>Kang, In-Gu</creatorcontrib><creatorcontrib>Cheon, Kwang-Hee</creatorcontrib><creatorcontrib>Jang, Tae-Sik</creatorcontrib><creatorcontrib>Kim, Hyoun-Ee</creatorcontrib><creatorcontrib>Jung, Hyun-Do</creatorcontrib><creatorcontrib>Kang, Min-Ho</creatorcontrib><title>Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant</title><title>Polymers</title><description>Poly(L-lactic) acid (PLLA) is among the most promising polymers for bone fixation, repair, and tissue engineering due to its biodegradability and relatively good mechanical strength. 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These results confirm patterned HA/PLLA as a candidate for wide acceptance in biodegradable load-bearing implant applications.</description><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Cell growth</subject><subject>Ceramic glazes</subject><subject>Contact angle</subject><subject>Degeneration</subject><subject>Delamination</subject><subject>Hydroxyapatite</subject><subject>Mechanical properties</subject><subject>Micropatterning</subject><subject>Morphology</subject><subject>Polylactic acid</subject><subject>Protective coatings</subject><subject>Scanning electron microscopy</subject><subject>Silicon wafers</subject><subject>Tensile strength</subject><subject>Tension tests</subject><subject>Tissue engineering</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdUUtLxDAQDqKoqEfvAS96qObRNpuLoLI-YEUPeg5pMtFI29Q0u9h_bxZF1LnM65uPb2YQOqTklHNJzobQTh1llLCcbaBdRgQvSl6TzV_xDjoYxzeSrazqmopttMM5mREhxC7q5v2r7g1YfOmDNsmvfJpwcPjemxgGnRLEPndvJxvDx6RzxSfA864Ba3P9MSs4XhTtetSc4AvjLXYhYo0XQdviEnT0_Qu-64ZW92kfbTndjnDw7ffQ8_X86eq2WDzc3F1dLAqTBadCmFpWUkrLDDBmHBWME0MFNEYKJp0TuuQN17RyVoIkcmY0AIXGyRmjzvI9dP7FOyybDqyBPkXdqiH6TsdJBe3V307vX9VLWClRE05qlgmOvwlieF_CmFTnRwNtXgLCclSsrJiclVysoUf_oG9hGfu8nmJVRVhVc1FnVPGFylcdxwjuRwwlav1L9eeX_BOPHJI2</recordid><startdate>20201017</startdate><enddate>20201017</enddate><creator>Kim, Sae-Mi</creator><creator>Kang, In-Gu</creator><creator>Cheon, Kwang-Hee</creator><creator>Jang, Tae-Sik</creator><creator>Kim, Hyoun-Ee</creator><creator>Jung, Hyun-Do</creator><creator>Kang, Min-Ho</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8632-7431</orcidid></search><sort><creationdate>20201017</creationdate><title>Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant</title><author>Kim, Sae-Mi ; 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Despite these beneficial characteristics, its poor bioactivity often requires incorporation of bioactive ceramic materials. A bioresorbable composite made of PLLA and hydroxyapatite (HA) may improve biocompatibility but typically causes deterioration in mechanical properties, and bioactive coatings inevitably carry a risk of coating delamination. Therefore, in this study, we embedded micropatterned HA on the surface of PLLA to improve bioactivity while eliminating the risk of HA delamination. An HA pattern was successfully embedded in a PLLA matrix without degeneration of the matrix’s mechanical properties, thanks to a transfer technique involving conversion of Mg to HA. Furthermore, patterned HA/PLLA’s biological response outperformed that of pure PLLA. 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| subjects | Biocompatibility Biodegradability Biological activity Biomedical materials Cell growth Ceramic glazes Contact angle Degeneration Delamination Hydroxyapatite Mechanical properties Micropatterning Morphology Polylactic acid Protective coatings Scanning electron microscopy Silicon wafers Tensile strength Tension tests Tissue engineering |
| title | Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant |
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