Inhibition of Melanoma Cell Migration and Invasion Targeting the Hypoxic Tumor Associated CAXII

Intratumoral hypoxia contributes to cancer progression and poor prognosis. Carbonic anhydrases IX (CAIX) and XII (CAXII) play pivotal roles in tumor cell adaptation and survival, as aberrant Hedgehog (Hh) pathway does. In malignant melanoma both features have been investigated for years, but they ha...

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Veröffentlicht in:	Cancers 2020-10, Vol.12 (10), p.3018
Hauptverfasser:	Giuntini, Gaia, Monaci, Sara, Cau, Ylenia, Mori, Mattia, Naldini, Antonella, Carraro, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Care and treatment Cell adhesion & migration Cell migration Cell survival Enzymes Genotype & phenotype Health aspects Hypoxia Immunofluorescence Invasiveness Medical prognosis Melanoma Metalloproteinase Metastases Metastasis Motility Phosphorylation Prevention Prognosis Protein expression Proteins Skin cancer
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