Srebf2 Locus Overexpression Reduces Body Weight, Total Cholesterol and Glucose Levels in Mice Fed with Two Different Diets
Macronutrients represent risk factors for hyperlipidemia or diabetes. Lipid alterations and type 2 diabetes mellitus are global health problems. Overexpression of sterol regulatory element-binding factor ( ) in transgenic animals is linked to elevated cholesterol levels and diabetes development. We...
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| Veröffentlicht in: | Nutrients 2020-10, Vol.12 (10), p.3130 |
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| creator | Andrés-Blasco, Irene Blesa, Sebastian Vinué, Ángela González-Navarro, Herminia Real, José Tomás Martínez-Hervás, Sergio Carretero, Julián Ferrández-Izquierdo, Antonio Chaves, Felipe Javier García-García, Ana-Bárbara |
| description | Macronutrients represent risk factors for hyperlipidemia or diabetes. Lipid alterations and type 2 diabetes mellitus are global health problems. Overexpression of sterol regulatory element-binding factor (
) in transgenic animals is linked to elevated cholesterol levels and diabetes development. We investigated the impact of increased
locus expression and the effects of control and high-fat, high-sucrose (HFHS) diets on body weight, glucose and lipid metabolisms in transgenic mice (
). Wild type (
) and
were fed with both diets for 16 weeks. Plasma glucose, insulin and lipids were assessed (
= 25). Immunostainings were performed in liver, pancreas and fat (N = 10). Expression of
and
in liver was performed by RT-PCR (N = 8). Control diet:
showed reduced weight, insulin, total and HDL cholesterol and triglycerides (TG). HFHS diet widened differences in weight, total and HDL cholesterol, insulin and HOMA index but increased TG in
. In
adipocyte size was lower while HFHS diet produced lower increase, pancreatic β-cell mass was lower with both diets and
,
and
mRNA levels were higher while HFHS diet produced a rise in
and
levels.
complete gene overexpression seems to have beneficial effects on metabolic parameters and to protect against HFHS diet effects. |
| doi_str_mv | 10.3390/nu12103130 |
| format | Article |
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) in transgenic animals is linked to elevated cholesterol levels and diabetes development. We investigated the impact of increased
locus expression and the effects of control and high-fat, high-sucrose (HFHS) diets on body weight, glucose and lipid metabolisms in transgenic mice (
). Wild type (
) and
were fed with both diets for 16 weeks. Plasma glucose, insulin and lipids were assessed (
= 25). Immunostainings were performed in liver, pancreas and fat (N = 10). Expression of
and
in liver was performed by RT-PCR (N = 8). Control diet:
showed reduced weight, insulin, total and HDL cholesterol and triglycerides (TG). HFHS diet widened differences in weight, total and HDL cholesterol, insulin and HOMA index but increased TG in
. In
adipocyte size was lower while HFHS diet produced lower increase, pancreatic β-cell mass was lower with both diets and
,
and
mRNA levels were higher while HFHS diet produced a rise in
and
levels.
complete gene overexpression seems to have beneficial effects on metabolic parameters and to protect against HFHS diet effects.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12103130</identifier><identifier>PMID: 33066385</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipocytes ; Animals ; Atherosclerosis ; Beta cells ; Blood Glucose ; Body Weight ; Cholesterol ; Cholesterol - blood ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - metabolism ; Diet ; Diet, High-Fat - adverse effects ; Dietary Sucrose - adverse effects ; Female ; Food ; Gene Expression ; Global health ; Glucose ; Glycerol ; Health problems ; High density lipoprotein ; High fat diet ; Hyperlipidemia ; Insulin ; Insulin - blood ; Insulin resistance ; Laboratories ; Lipid Metabolism ; Lipids ; Liver ; Loci ; Male ; Metabolic disorders ; Mice, Inbred C57BL ; Mice, Transgenic ; mRNA ; Pancreas ; Plasma ; Polymerase chain reaction ; Proteins ; Public health ; Regulatory sequences ; Risk analysis ; Risk factors ; Sterol Regulatory Element Binding Protein 2 - genetics ; Sterol Regulatory Element Binding Protein 2 - metabolism ; Sterols ; Sucrose ; Transgenic animals ; Transgenic mice ; Triglycerides ; Weight reduction</subject><ispartof>Nutrients, 2020-10, Vol.12 (10), p.3130</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-214045b4140cde5589117b140fb33e9a34c7b1f8e0d113a397a286d9b6ddebf03</citedby><cites>FETCH-LOGICAL-c406t-214045b4140cde5589117b140fb33e9a34c7b1f8e0d113a397a286d9b6ddebf03</cites><orcidid>0000-0002-2162-6606 ; 0000-0002-6775-2034</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602228/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602228/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33066385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andrés-Blasco, Irene</creatorcontrib><creatorcontrib>Blesa, Sebastian</creatorcontrib><creatorcontrib>Vinué, Ángela</creatorcontrib><creatorcontrib>González-Navarro, Herminia</creatorcontrib><creatorcontrib>Real, José Tomás</creatorcontrib><creatorcontrib>Martínez-Hervás, Sergio</creatorcontrib><creatorcontrib>Carretero, Julián</creatorcontrib><creatorcontrib>Ferrández-Izquierdo, Antonio</creatorcontrib><creatorcontrib>Chaves, Felipe Javier</creatorcontrib><creatorcontrib>García-García, Ana-Bárbara</creatorcontrib><title>Srebf2 Locus Overexpression Reduces Body Weight, Total Cholesterol and Glucose Levels in Mice Fed with Two Different Diets</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Macronutrients represent risk factors for hyperlipidemia or diabetes. Lipid alterations and type 2 diabetes mellitus are global health problems. Overexpression of sterol regulatory element-binding factor (
) in transgenic animals is linked to elevated cholesterol levels and diabetes development. We investigated the impact of increased
locus expression and the effects of control and high-fat, high-sucrose (HFHS) diets on body weight, glucose and lipid metabolisms in transgenic mice (
). Wild type (
) and
were fed with both diets for 16 weeks. Plasma glucose, insulin and lipids were assessed (
= 25). Immunostainings were performed in liver, pancreas and fat (N = 10). Expression of
and
in liver was performed by RT-PCR (N = 8). Control diet:
showed reduced weight, insulin, total and HDL cholesterol and triglycerides (TG). HFHS diet widened differences in weight, total and HDL cholesterol, insulin and HOMA index but increased TG in
. In
adipocyte size was lower while HFHS diet produced lower increase, pancreatic β-cell mass was lower with both diets and
,
and
mRNA levels were higher while HFHS diet produced a rise in
and
levels.
complete gene overexpression seems to have beneficial effects on metabolic parameters and to protect against HFHS diet effects.</description><subject>Adipocytes</subject><subject>Animals</subject><subject>Atherosclerosis</subject><subject>Beta cells</subject><subject>Blood Glucose</subject><subject>Body Weight</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dietary Sucrose - adverse effects</subject><subject>Female</subject><subject>Food</subject><subject>Gene Expression</subject><subject>Global health</subject><subject>Glucose</subject><subject>Glycerol</subject><subject>Health problems</subject><subject>High density lipoprotein</subject><subject>High fat diet</subject><subject>Hyperlipidemia</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>Laboratories</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Liver</subject><subject>Loci</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>mRNA</subject><subject>Pancreas</subject><subject>Plasma</subject><subject>Polymerase chain reaction</subject><subject>Proteins</subject><subject>Public health</subject><subject>Regulatory sequences</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Sterol Regulatory Element Binding Protein 2 - genetics</subject><subject>Sterol Regulatory Element Binding Protein 2 - metabolism</subject><subject>Sterols</subject><subject>Sucrose</subject><subject>Transgenic animals</subject><subject>Transgenic mice</subject><subject>Triglycerides</subject><subject>Weight reduction</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpVUU1P3DAQtSpQF8Fe-gMqS72hLtiexEkuSHT5lBYhtVv1aDn2hDUK8WIny8evxyvoAnOZeZqnN2_0CPnG2QFAxQ67gQvOgAP7QnYEK8REygy2PswjMo7xlq2rYIWEr2QEwKSEMt8hz38C1o2gM2-GSK9XGPBxGTBG5zv6G-1gMNJf3j7Rf-huFv1POve9bul04VuMPQbfUt1Zet4OxkekM1xhG6nr6JUzSM_Q0gfXL-j8wdMT1zRJv-vThH3cI9uNbiOO3_ou-Xt2Op9eTGbX55fT49nEZEz2E8EzluV1lpqxmOdlxXlRJ9TUAFhpyEyCTYnMcg4aqkKLUtqqltam1xjskqNX3eVQ36E1yUDQrVoGd6fDk_Laqc-bzi3UjV-pQjIhRJkEfrwJBH8_pK_VrR9ClzwrkUOeMZHleWLtv7JM8DEGbDYXOFPrqNR7VIn8_aOnDfV_MPACMtiPBg</recordid><startdate>20201014</startdate><enddate>20201014</enddate><creator>Andrés-Blasco, Irene</creator><creator>Blesa, Sebastian</creator><creator>Vinué, Ángela</creator><creator>González-Navarro, Herminia</creator><creator>Real, José Tomás</creator><creator>Martínez-Hervás, Sergio</creator><creator>Carretero, Julián</creator><creator>Ferrández-Izquierdo, Antonio</creator><creator>Chaves, Felipe Javier</creator><creator>García-García, Ana-Bárbara</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2162-6606</orcidid><orcidid>https://orcid.org/0000-0002-6775-2034</orcidid></search><sort><creationdate>20201014</creationdate><title>Srebf2 Locus Overexpression Reduces Body Weight, Total Cholesterol and Glucose Levels in Mice Fed with Two Different Diets</title><author>Andrés-Blasco, Irene ; Blesa, Sebastian ; Vinué, Ángela ; González-Navarro, Herminia ; Real, José Tomás ; Martínez-Hervás, Sergio ; Carretero, Julián ; Ferrández-Izquierdo, Antonio ; Chaves, Felipe Javier ; García-García, Ana-Bárbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-214045b4140cde5589117b140fb33e9a34c7b1f8e0d113a397a286d9b6ddebf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipocytes</topic><topic>Animals</topic><topic>Atherosclerosis</topic><topic>Beta cells</topic><topic>Blood Glucose</topic><topic>Body Weight</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Dietary Sucrose - adverse effects</topic><topic>Female</topic><topic>Food</topic><topic>Gene Expression</topic><topic>Global health</topic><topic>Glucose</topic><topic>Glycerol</topic><topic>Health problems</topic><topic>High density lipoprotein</topic><topic>High fat diet</topic><topic>Hyperlipidemia</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin resistance</topic><topic>Laboratories</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Liver</topic><topic>Loci</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>mRNA</topic><topic>Pancreas</topic><topic>Plasma</topic><topic>Polymerase chain reaction</topic><topic>Proteins</topic><topic>Public health</topic><topic>Regulatory sequences</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Sterol Regulatory Element Binding Protein 2 - genetics</topic><topic>Sterol Regulatory Element Binding Protein 2 - metabolism</topic><topic>Sterols</topic><topic>Sucrose</topic><topic>Transgenic animals</topic><topic>Transgenic mice</topic><topic>Triglycerides</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andrés-Blasco, Irene</creatorcontrib><creatorcontrib>Blesa, Sebastian</creatorcontrib><creatorcontrib>Vinué, Ángela</creatorcontrib><creatorcontrib>González-Navarro, Herminia</creatorcontrib><creatorcontrib>Real, José Tomás</creatorcontrib><creatorcontrib>Martínez-Hervás, Sergio</creatorcontrib><creatorcontrib>Carretero, Julián</creatorcontrib><creatorcontrib>Ferrández-Izquierdo, Antonio</creatorcontrib><creatorcontrib>Chaves, Felipe Javier</creatorcontrib><creatorcontrib>García-García, Ana-Bárbara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrés-Blasco, Irene</au><au>Blesa, Sebastian</au><au>Vinué, Ángela</au><au>González-Navarro, Herminia</au><au>Real, José Tomás</au><au>Martínez-Hervás, Sergio</au><au>Carretero, Julián</au><au>Ferrández-Izquierdo, Antonio</au><au>Chaves, Felipe Javier</au><au>García-García, Ana-Bárbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Srebf2 Locus Overexpression Reduces Body Weight, Total Cholesterol and Glucose Levels in Mice Fed with Two Different Diets</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2020-10-14</date><risdate>2020</risdate><volume>12</volume><issue>10</issue><spage>3130</spage><pages>3130-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Macronutrients represent risk factors for hyperlipidemia or diabetes. Lipid alterations and type 2 diabetes mellitus are global health problems. Overexpression of sterol regulatory element-binding factor (
) in transgenic animals is linked to elevated cholesterol levels and diabetes development. We investigated the impact of increased
locus expression and the effects of control and high-fat, high-sucrose (HFHS) diets on body weight, glucose and lipid metabolisms in transgenic mice (
). Wild type (
) and
were fed with both diets for 16 weeks. Plasma glucose, insulin and lipids were assessed (
= 25). Immunostainings were performed in liver, pancreas and fat (N = 10). Expression of
and
in liver was performed by RT-PCR (N = 8). Control diet:
showed reduced weight, insulin, total and HDL cholesterol and triglycerides (TG). HFHS diet widened differences in weight, total and HDL cholesterol, insulin and HOMA index but increased TG in
. In
adipocyte size was lower while HFHS diet produced lower increase, pancreatic β-cell mass was lower with both diets and
,
and
mRNA levels were higher while HFHS diet produced a rise in
and
levels.
complete gene overexpression seems to have beneficial effects on metabolic parameters and to protect against HFHS diet effects.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33066385</pmid><doi>10.3390/nu12103130</doi><orcidid>https://orcid.org/0000-0002-2162-6606</orcidid><orcidid>https://orcid.org/0000-0002-6775-2034</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adipocytes Animals Atherosclerosis Beta cells Blood Glucose Body Weight Cholesterol Cholesterol - blood Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - metabolism Diet Diet, High-Fat - adverse effects Dietary Sucrose - adverse effects Female Food Gene Expression Global health Glucose Glycerol Health problems High density lipoprotein High fat diet Hyperlipidemia Insulin Insulin - blood Insulin resistance Laboratories Lipid Metabolism Lipids Liver Loci Male Metabolic disorders Mice, Inbred C57BL Mice, Transgenic mRNA Pancreas Plasma Polymerase chain reaction Proteins Public health Regulatory sequences Risk analysis Risk factors Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism Sterols Sucrose Transgenic animals Transgenic mice Triglycerides Weight reduction |
| title | Srebf2 Locus Overexpression Reduces Body Weight, Total Cholesterol and Glucose Levels in Mice Fed with Two Different Diets |
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