Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer

The prostate cancer (PCa) field lacks clinically relevant, syngeneic mouse models which retain the tumour microenvironment observed in PCa patients. This study establishes a cell line from prostate tumour tissue derived from the mouse, termed DVL3 which when subcutaneously implanted in immunocompete...

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Veröffentlicht in:	Cancers 2020-09, Vol.12 (10), p.2804
Hauptverfasser:	Haughey, Charles M, Mukherjee, Debayan, Steele, Rebecca E, Popple, Amy, Dura-Perez, Lara, Pickard, Adam, Patel, Mehjabin, Jain, Suneil, Mullan, Paul B, Williams, Rich, Oliveira, Pedro, Buckley, Niamh E, Honeychurch, Jamie, S McDade, Simon, Illidge, Timothy, Mills, Ian G, Eddie, Sharon L
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptors Androgens Animal models Cancer therapies CD8 antigen Cold Cytokeratin Dishevelled protein Epithelium Flow cytometry Immunohistochemistry Interferon Lymphocytes T Melanoma Metastases Metastasis Microenvironments Patient outcomes Patients Prostate cancer Protein expression Proteins PTEN protein Radiation therapy Radiotherapy Suppressor cells Tumor microenvironment Tumors
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