Dynamic networks observed in the nucleosome core particles couple the histone globular domains with DNA

The dynamics of eukaryotic nucleosomes are essential in gene activity and well regulated by various factors. Here, we elucidated the internal dynamics at multiple timescales for the human histones hH3 and hH4 in the Widom 601 nucleosome core particles (NCP), suggesting that four dynamic networks are...

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Veröffentlicht in:	Communications biology 2020-10, Vol.3 (1), p.639-639, Article 639
Hauptverfasser:	Shi, Xiangyan, Prasanna, Chinmayi, Soman, Aghil, Pervushin, Konstantin, Nordenskiöld, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	101/6 631/208 631/45 631/57 Biology Biomedical and Life Sciences Core particles Deoxyribonucleic acid DNA Epigenetics Histones Life Sciences Magnetic resonance spectroscopy NMR Nuclear magnetic resonance Nucleosomes
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