Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population

Convalescent plasma is a leading treatment for coronavirus disease 2019 (COVID-19), but there is a paucity of data identifying its therapeutic efficacy. Among 126 potential convalescent plasma donors, the humoral immune response was evaluated using a severe acute respiratory syndrome coronavirus 2 (...

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Veröffentlicht in:	The Journal of clinical investigation 2020-11, Vol.130 (11), p.6141-6150
Hauptverfasser:	Klein, Sabra L, Pekosz, Andrew, Park, Han-Sol, Ursin, Rebecca L, Shapiro, Janna R, Benner, Sarah E, Littlefield, Kirsten, Kumar, Swetha, Naik, Harnish Mukesh, Betenbaugh, Michael J, Shrestha, Ruchee, Wu, Annie A, Hughes, Robert M, Burgess, Imani, Caturegli, Patricio, Laeyendecker, Oliver, Quinn, Thomas C, Sullivan, David, Shoham, Shmuel, Redd, Andrew D, Bloch, Evan M, Casadevall, Arturo, Tobian, Aaron Ar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age Factors Aged Animals Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Formation Antibody response Antigen-antibody reactions Avidity Betacoronavirus - immunology Betacoronavirus - metabolism Biomedical research Blood Donors Care and treatment Chlorocebus aethiops Convalescence Convalescent plasma therapy Coronaviridae Coronavirus Infections - blood Coronavirus Infections - immunology Coronavirus Infections - therapy Coronaviruses COVID-19 Demographic aspects Development and progression Disease age factors Enzyme-linked immunosorbent assay Female Hospital patients Hospitalization Humans Immune response (humoral) Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunologic research Infections Male Males Middle Aged Pandemics Patient outcomes Plasma Pneumonia, Viral - blood Pneumonia, Viral - immunology Pneumonia, Viral - therapy Prediction models Proteins Regression analysis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Sex Factors Vero Cells Viral infections
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