Assessment of Birth Defects and Cancer Risk in Children Conceived via In Vitro Fertilization in the US
Children with birth defects have a greater risk of developing cancer, but this association has not yet been evaluated in children conceived with in vitro fertilization (IVF). To assess whether the association between birth defects and cancer is greater in children conceived via IVF compared with chi...
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| creator | Luke, Barbara Brown, Morton B Nichols, Hazel B Schymura, Maria J Browne, Marilyn L Fisher, Sarah C Forestieri, Nina E Rao, Chandrika Yazdy, Mahsa M Gershman, Susan T Ethen, Mary K Canfield, Mark A Williams, Melanie Wantman, Ethan Oehninger, Sergio Doody, Kevin J Eisenberg, Michael L Baker, Valerie L Lupo, Philip J |
| description | Children with birth defects have a greater risk of developing cancer, but this association has not yet been evaluated in children conceived with in vitro fertilization (IVF).
To assess whether the association between birth defects and cancer is greater in children conceived via IVF compared with children conceived naturally.
This cohort study of live births, birth defects, and cancer from Massachusetts, New York, North Carolina, and Texas included 1 000 639 children born to fertile women and 52 776 children conceived via IVF (using autologous oocytes and fresh embryos) during 2004-2016 in Massachusetts and North Carolina, 2004-2015 in New York, and 2004-2013 in Texas. Children were followed up for an average of 5.7 years (6 008 985 total person-years of exposure). Data analysis was conducted from April 1 to August 31, 2020.
Conception by IVF for state residents who gave birth to liveborn singletons during the study period. Birth defect diagnoses recorded by statewide registries.
Cancer diagnosis as recorded by state cancer registries. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs for birth defect-cancer associations separately in fertile and IVF groups.
A total of 1 000 639 children (51.3% boys; 69.7% White; and 38.3% born between 2009-2012) were in the fertile group and 52 776 were in the IVF group (51.3% boys; 81.3% White; and 39.6% born between 2009-2012). Compared with children without birth defects, cancer risks were higher among children with a major birth defect in the fertile group (hazard ratio [HR], 3.15; 95% CI, 2.40-4.14) and IVF group (HR, 6.90; 95% CI, 3.73-12.74). The HR of cancer among children with a major nonchromosomal defect was 2.07 (95% CI, 1.47-2.91) among children in the fertile group and 4.04 (95% CI, 1.86-8.77) among children in the IVF group. The HR of cancer among children with a chromosomal defect was 15.45 (95% CI, 10.00-23.86) in the fertile group and 38.91 (95% CI, 15.56-97.33) in the IVF group.
This study found that among children with birth defects, those conceived via IVF were at greater risk of developing cancer compared with children conceived naturally. |
| doi_str_mv | 10.1001/jamanetworkopen.2020.22927 |
| format | Article |
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To assess whether the association between birth defects and cancer is greater in children conceived via IVF compared with children conceived naturally.
This cohort study of live births, birth defects, and cancer from Massachusetts, New York, North Carolina, and Texas included 1 000 639 children born to fertile women and 52 776 children conceived via IVF (using autologous oocytes and fresh embryos) during 2004-2016 in Massachusetts and North Carolina, 2004-2015 in New York, and 2004-2013 in Texas. Children were followed up for an average of 5.7 years (6 008 985 total person-years of exposure). Data analysis was conducted from April 1 to August 31, 2020.
Conception by IVF for state residents who gave birth to liveborn singletons during the study period. Birth defect diagnoses recorded by statewide registries.
Cancer diagnosis as recorded by state cancer registries. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs for birth defect-cancer associations separately in fertile and IVF groups.
A total of 1 000 639 children (51.3% boys; 69.7% White; and 38.3% born between 2009-2012) were in the fertile group and 52 776 were in the IVF group (51.3% boys; 81.3% White; and 39.6% born between 2009-2012). Compared with children without birth defects, cancer risks were higher among children with a major birth defect in the fertile group (hazard ratio [HR], 3.15; 95% CI, 2.40-4.14) and IVF group (HR, 6.90; 95% CI, 3.73-12.74). The HR of cancer among children with a major nonchromosomal defect was 2.07 (95% CI, 1.47-2.91) among children in the fertile group and 4.04 (95% CI, 1.86-8.77) among children in the IVF group. The HR of cancer among children with a chromosomal defect was 15.45 (95% CI, 10.00-23.86) in the fertile group and 38.91 (95% CI, 15.56-97.33) in the IVF group.
This study found that among children with birth defects, those conceived via IVF were at greater risk of developing cancer compared with children conceived naturally.</description><identifier>ISSN: 2574-3805</identifier><identifier>EISSN: 2574-3805</identifier><identifier>DOI: 10.1001/jamanetworkopen.2020.22927</identifier><identifier>PMID: 33119107</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adolescent ; Adult ; Birth defects ; Cancer ; Cohort Studies ; Congenital Abnormalities - diagnosis ; Congenital Abnormalities - epidemiology ; Female ; Fertilization in Vitro - adverse effects ; Fertilization in Vitro - methods ; Fertilization in Vitro - statistics & numerical data ; Humans ; In vitro fertilization ; Male ; Massachusetts - epidemiology ; Neoplasms - diagnosis ; Neoplasms - epidemiology ; New York - epidemiology ; North Carolina - epidemiology ; Oncology ; Online Only ; Original Investigation ; Population Surveillance - methods ; Pregnancy ; Pregnancy Outcome - epidemiology ; Registries - statistics & numerical data ; Risk Assessment - methods ; Risk Assessment - statistics & numerical data ; Texas - epidemiology</subject><ispartof>JAMA network open, 2020-10, Vol.3 (10), p.e2022927</ispartof><rights>2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright 2020 Luke B et al. .</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a473t-ee28304e4269a02570c4282790e77aaff5265ea5c2bc15a15ea92eb3be17768e3</citedby><cites>FETCH-LOGICAL-a473t-ee28304e4269a02570c4282790e77aaff5265ea5c2bc15a15ea92eb3be17768e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33119107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luke, Barbara</creatorcontrib><creatorcontrib>Brown, Morton B</creatorcontrib><creatorcontrib>Nichols, Hazel B</creatorcontrib><creatorcontrib>Schymura, Maria J</creatorcontrib><creatorcontrib>Browne, Marilyn L</creatorcontrib><creatorcontrib>Fisher, Sarah C</creatorcontrib><creatorcontrib>Forestieri, Nina E</creatorcontrib><creatorcontrib>Rao, Chandrika</creatorcontrib><creatorcontrib>Yazdy, Mahsa M</creatorcontrib><creatorcontrib>Gershman, Susan T</creatorcontrib><creatorcontrib>Ethen, Mary K</creatorcontrib><creatorcontrib>Canfield, Mark A</creatorcontrib><creatorcontrib>Williams, Melanie</creatorcontrib><creatorcontrib>Wantman, Ethan</creatorcontrib><creatorcontrib>Oehninger, Sergio</creatorcontrib><creatorcontrib>Doody, Kevin J</creatorcontrib><creatorcontrib>Eisenberg, Michael L</creatorcontrib><creatorcontrib>Baker, Valerie L</creatorcontrib><creatorcontrib>Lupo, Philip J</creatorcontrib><title>Assessment of Birth Defects and Cancer Risk in Children Conceived via In Vitro Fertilization in the US</title><title>JAMA network open</title><addtitle>JAMA Netw Open</addtitle><description>Children with birth defects have a greater risk of developing cancer, but this association has not yet been evaluated in children conceived with in vitro fertilization (IVF).
To assess whether the association between birth defects and cancer is greater in children conceived via IVF compared with children conceived naturally.
This cohort study of live births, birth defects, and cancer from Massachusetts, New York, North Carolina, and Texas included 1 000 639 children born to fertile women and 52 776 children conceived via IVF (using autologous oocytes and fresh embryos) during 2004-2016 in Massachusetts and North Carolina, 2004-2015 in New York, and 2004-2013 in Texas. Children were followed up for an average of 5.7 years (6 008 985 total person-years of exposure). Data analysis was conducted from April 1 to August 31, 2020.
Conception by IVF for state residents who gave birth to liveborn singletons during the study period. Birth defect diagnoses recorded by statewide registries.
Cancer diagnosis as recorded by state cancer registries. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs for birth defect-cancer associations separately in fertile and IVF groups.
A total of 1 000 639 children (51.3% boys; 69.7% White; and 38.3% born between 2009-2012) were in the fertile group and 52 776 were in the IVF group (51.3% boys; 81.3% White; and 39.6% born between 2009-2012). Compared with children without birth defects, cancer risks were higher among children with a major birth defect in the fertile group (hazard ratio [HR], 3.15; 95% CI, 2.40-4.14) and IVF group (HR, 6.90; 95% CI, 3.73-12.74). The HR of cancer among children with a major nonchromosomal defect was 2.07 (95% CI, 1.47-2.91) among children in the fertile group and 4.04 (95% CI, 1.86-8.77) among children in the IVF group. The HR of cancer among children with a chromosomal defect was 15.45 (95% CI, 10.00-23.86) in the fertile group and 38.91 (95% CI, 15.56-97.33) in the IVF group.
This study found that among children with birth defects, those conceived via IVF were at greater risk of developing cancer compared with children conceived naturally.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Birth defects</subject><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Congenital Abnormalities - diagnosis</subject><subject>Congenital Abnormalities - epidemiology</subject><subject>Female</subject><subject>Fertilization in Vitro - adverse effects</subject><subject>Fertilization in Vitro - methods</subject><subject>Fertilization in Vitro - statistics & numerical data</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Male</subject><subject>Massachusetts - epidemiology</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - epidemiology</subject><subject>New York - epidemiology</subject><subject>North Carolina - epidemiology</subject><subject>Oncology</subject><subject>Online Only</subject><subject>Original Investigation</subject><subject>Population Surveillance - methods</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Registries - statistics & numerical data</subject><subject>Risk Assessment - methods</subject><subject>Risk Assessment - statistics & numerical data</subject><subject>Texas - epidemiology</subject><issn>2574-3805</issn><issn>2574-3805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdUdtKAzEUDKKoqL8gQV98ac1ls9n4IGi9giB4ew3p9qxN3U1qklb06029oT6d4WRmyJxBaIeSPiWE7k9MZxykFx-e_BRcnxFG-owpJpfQOhOy6PGKiOVfeA1txTghJBMpV6VYRWucU6ookeuoOYoRYuzAJewbfGxDGuMTaKBOERs3wgPjagj4xsYnbB0ejG07CpCBz3s7hxGeW4MvHX6wKXh8BiHZ1r6ZZL1bCNIY8P3tJlppTBth62tuoPuz07vBRe_q-vxycHTVM4XkqQfAKk4KKFipDMkJSF2wiklFQEpjmkawUoARNRvWVBiasWIw5EOgUpYV8A10-Ok7nQ07GNU5VjCtngbbmfCqvbH674uzY_3o51qKfBkpssHel0HwzzOISXc21tC2-eh-FjUrhKgKWimeqbv_qBM_Cy7H06wsZaWEVCyzDj5ZdfAxBmh-PkOJXjSq_zWqF43qj0azePt3nB_pd3_8HUXpofM</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Luke, Barbara</creator><creator>Brown, Morton B</creator><creator>Nichols, Hazel B</creator><creator>Schymura, Maria J</creator><creator>Browne, Marilyn L</creator><creator>Fisher, Sarah C</creator><creator>Forestieri, Nina E</creator><creator>Rao, Chandrika</creator><creator>Yazdy, Mahsa M</creator><creator>Gershman, Susan T</creator><creator>Ethen, Mary K</creator><creator>Canfield, Mark A</creator><creator>Williams, Melanie</creator><creator>Wantman, Ethan</creator><creator>Oehninger, Sergio</creator><creator>Doody, Kevin J</creator><creator>Eisenberg, Michael L</creator><creator>Baker, Valerie L</creator><creator>Lupo, Philip J</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201001</creationdate><title>Assessment of Birth Defects and Cancer Risk in Children Conceived via In Vitro Fertilization in the US</title><author>Luke, Barbara ; Brown, Morton B ; Nichols, Hazel B ; Schymura, Maria J ; Browne, Marilyn L ; Fisher, Sarah C ; Forestieri, Nina E ; Rao, Chandrika ; Yazdy, Mahsa M ; Gershman, Susan T ; Ethen, Mary K ; Canfield, Mark A ; Williams, Melanie ; Wantman, Ethan ; Oehninger, Sergio ; Doody, Kevin J ; Eisenberg, Michael L ; Baker, Valerie L ; Lupo, Philip J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a473t-ee28304e4269a02570c4282790e77aaff5265ea5c2bc15a15ea92eb3be17768e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Birth defects</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Congenital Abnormalities - diagnosis</topic><topic>Congenital Abnormalities - epidemiology</topic><topic>Female</topic><topic>Fertilization in Vitro - adverse effects</topic><topic>Fertilization in Vitro - methods</topic><topic>Fertilization in Vitro - statistics & numerical data</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Male</topic><topic>Massachusetts - epidemiology</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - epidemiology</topic><topic>New York - epidemiology</topic><topic>North Carolina - epidemiology</topic><topic>Oncology</topic><topic>Online Only</topic><topic>Original Investigation</topic><topic>Population Surveillance - methods</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Registries - statistics & numerical data</topic><topic>Risk Assessment - methods</topic><topic>Risk Assessment - statistics & numerical data</topic><topic>Texas - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luke, Barbara</creatorcontrib><creatorcontrib>Brown, Morton B</creatorcontrib><creatorcontrib>Nichols, Hazel B</creatorcontrib><creatorcontrib>Schymura, Maria J</creatorcontrib><creatorcontrib>Browne, Marilyn L</creatorcontrib><creatorcontrib>Fisher, Sarah C</creatorcontrib><creatorcontrib>Forestieri, Nina E</creatorcontrib><creatorcontrib>Rao, Chandrika</creatorcontrib><creatorcontrib>Yazdy, Mahsa M</creatorcontrib><creatorcontrib>Gershman, Susan T</creatorcontrib><creatorcontrib>Ethen, Mary K</creatorcontrib><creatorcontrib>Canfield, Mark A</creatorcontrib><creatorcontrib>Williams, Melanie</creatorcontrib><creatorcontrib>Wantman, Ethan</creatorcontrib><creatorcontrib>Oehninger, Sergio</creatorcontrib><creatorcontrib>Doody, Kevin J</creatorcontrib><creatorcontrib>Eisenberg, Michael L</creatorcontrib><creatorcontrib>Baker, Valerie L</creatorcontrib><creatorcontrib>Lupo, Philip J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA network open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luke, Barbara</au><au>Brown, Morton B</au><au>Nichols, Hazel B</au><au>Schymura, Maria J</au><au>Browne, Marilyn L</au><au>Fisher, Sarah C</au><au>Forestieri, Nina E</au><au>Rao, Chandrika</au><au>Yazdy, Mahsa M</au><au>Gershman, Susan T</au><au>Ethen, Mary K</au><au>Canfield, Mark A</au><au>Williams, Melanie</au><au>Wantman, Ethan</au><au>Oehninger, Sergio</au><au>Doody, Kevin J</au><au>Eisenberg, Michael L</au><au>Baker, Valerie L</au><au>Lupo, Philip J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of Birth Defects and Cancer Risk in Children Conceived via In Vitro Fertilization in the US</atitle><jtitle>JAMA network open</jtitle><addtitle>JAMA Netw Open</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>3</volume><issue>10</issue><spage>e2022927</spage><pages>e2022927-</pages><issn>2574-3805</issn><eissn>2574-3805</eissn><abstract>Children with birth defects have a greater risk of developing cancer, but this association has not yet been evaluated in children conceived with in vitro fertilization (IVF).
To assess whether the association between birth defects and cancer is greater in children conceived via IVF compared with children conceived naturally.
This cohort study of live births, birth defects, and cancer from Massachusetts, New York, North Carolina, and Texas included 1 000 639 children born to fertile women and 52 776 children conceived via IVF (using autologous oocytes and fresh embryos) during 2004-2016 in Massachusetts and North Carolina, 2004-2015 in New York, and 2004-2013 in Texas. Children were followed up for an average of 5.7 years (6 008 985 total person-years of exposure). Data analysis was conducted from April 1 to August 31, 2020.
Conception by IVF for state residents who gave birth to liveborn singletons during the study period. Birth defect diagnoses recorded by statewide registries.
Cancer diagnosis as recorded by state cancer registries. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs for birth defect-cancer associations separately in fertile and IVF groups.
A total of 1 000 639 children (51.3% boys; 69.7% White; and 38.3% born between 2009-2012) were in the fertile group and 52 776 were in the IVF group (51.3% boys; 81.3% White; and 39.6% born between 2009-2012). Compared with children without birth defects, cancer risks were higher among children with a major birth defect in the fertile group (hazard ratio [HR], 3.15; 95% CI, 2.40-4.14) and IVF group (HR, 6.90; 95% CI, 3.73-12.74). The HR of cancer among children with a major nonchromosomal defect was 2.07 (95% CI, 1.47-2.91) among children in the fertile group and 4.04 (95% CI, 1.86-8.77) among children in the IVF group. The HR of cancer among children with a chromosomal defect was 15.45 (95% CI, 10.00-23.86) in the fertile group and 38.91 (95% CI, 15.56-97.33) in the IVF group.
This study found that among children with birth defects, those conceived via IVF were at greater risk of developing cancer compared with children conceived naturally.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>33119107</pmid><doi>10.1001/jamanetworkopen.2020.22927</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Birth defects Cancer Cohort Studies Congenital Abnormalities - diagnosis Congenital Abnormalities - epidemiology Female Fertilization in Vitro - adverse effects Fertilization in Vitro - methods Fertilization in Vitro - statistics & numerical data Humans In vitro fertilization Male Massachusetts - epidemiology Neoplasms - diagnosis Neoplasms - epidemiology New York - epidemiology North Carolina - epidemiology Oncology Online Only Original Investigation Population Surveillance - methods Pregnancy Pregnancy Outcome - epidemiology Registries - statistics & numerical data Risk Assessment - methods Risk Assessment - statistics & numerical data Texas - epidemiology |
| title | Assessment of Birth Defects and Cancer Risk in Children Conceived via In Vitro Fertilization in the US |
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