Circulating tumor DNA (ctDNA) detection is associated with shorter progression-free survival in advanced melanoma patients

BRAF , NRAS and TERT mutations occur in more than 2/3 of melanomas. Its detection in patient’s blood, as circulating tumor DNA (ctDNA), represents a possibility for identification and monitoring of metastatic disease. We proposed to standardize a liquid biopsy platform to identify hotspot mutations...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.18682-18682, Article 18682
Hauptverfasser:	Marczynski, Gabriella Taques, Laus, Ana Carolina, dos Reis, Mariana Bisarro, Reis, Rui Manuel, Vazquez, Vinicius de Lima
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1813/1634 692/4028/67/1857 692/53/2422 Adult Aged Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biopsy Circulating Tumor DNA - blood Circulating Tumor DNA - genetics Deoxyribonucleic acid Disease-Free Survival DNA Female GTP Phosphohydrolases - genetics Humanities and Social Sciences Humans Limit of Detection Liquid Biopsy Male Medical prognosis Melanoma Melanoma - blood Melanoma - pathology Membrane Proteins - genetics Metastases Middle Aged multidisciplinary Mutation Mutation hot spots Plasma Polymerase chain reaction Polymerase Chain Reaction - methods Prognosis Proto-Oncogene Proteins B-raf - genetics Science Science (multidisciplinary) Skin Neoplasms - blood Skin Neoplasms - pathology Telomerase - genetics Tumor cell lines Tumors
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