Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study
The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the ro...
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| creator | Bordoni, Laura Samulak, Joanna J. Sawicka, Angelika K. Pelikant-Malecka, Iwona Radulska, Adrianna Lewicki, Lukasz Kalinowski, Leszek Gabbianelli, Rosita Olek, Robert A. |
| description | The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association between TMAO and
CETP
polymorphisms (rs12720922 and rs247616), previously identified as a genetic determinant of circulating CETP, in a population of coronary artery disease (CAD) patients (n = 394) and control subjects (n = 153). We also considered age, sex, trimethylamine (TMA) levels and glomerular filtration rate (GFR) as other factors that can potentially play a role in this complex picture. We found no association of TMAO with genetically determined CETP in a population of CAD patients and control subjects. Moreover, we noticed no differences between CAD patients and control subjects in plasma TMAO levels. On the contrary, lower levels of TMA in CAD patients respect to controls were observed. Our results indicated a significant correlation between GFR and TMAO, but not TMA. The debate whether TMAO can be a harmful, diagnostic or protective marker in CVD needs to be continued. |
| doi_str_mv | 10.1038/s41598-020-75633-1 |
| format | Article |
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CETP
polymorphisms (rs12720922 and rs247616), previously identified as a genetic determinant of circulating CETP, in a population of coronary artery disease (CAD) patients (n = 394) and control subjects (n = 153). We also considered age, sex, trimethylamine (TMA) levels and glomerular filtration rate (GFR) as other factors that can potentially play a role in this complex picture. We found no association of TMAO with genetically determined CETP in a population of CAD patients and control subjects. Moreover, we noticed no differences between CAD patients and control subjects in plasma TMAO levels. On the contrary, lower levels of TMA in CAD patients respect to controls were observed. Our results indicated a significant correlation between GFR and TMAO, but not TMA. The debate whether TMAO can be a harmful, diagnostic or protective marker in CVD needs to be continued.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-75633-1</identifier><identifier>PMID: 33122777</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/53 ; Aged ; Arteriosclerosis ; Biological Transport ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - metabolism ; Case-Control Studies ; Cholesterol ; Cholesterol - metabolism ; Cholesterol Ester Transfer Proteins - blood ; Cholesterol Ester Transfer Proteins - genetics ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cholesteryl ester transfer protein ; Coronary artery ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate ; Haplotypes ; Heart diseases ; Humanities and Social Sciences ; Humans ; Macrophages ; Male ; Methylamines - metabolism ; Middle Aged ; multidisciplinary ; Polymorphism, Single Nucleotide ; Science ; Science (multidisciplinary) ; Trimethylamine</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.18675, Article 18675</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-56b2632cf1e2c4838dba393c0c4cf689b5b398d4bc1a171433fdf28c2c1922f13</citedby><cites>FETCH-LOGICAL-c474t-56b2632cf1e2c4838dba393c0c4cf689b5b398d4bc1a171433fdf28c2c1922f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596051/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596051/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33122777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bordoni, Laura</creatorcontrib><creatorcontrib>Samulak, Joanna J.</creatorcontrib><creatorcontrib>Sawicka, Angelika K.</creatorcontrib><creatorcontrib>Pelikant-Malecka, Iwona</creatorcontrib><creatorcontrib>Radulska, Adrianna</creatorcontrib><creatorcontrib>Lewicki, Lukasz</creatorcontrib><creatorcontrib>Kalinowski, Leszek</creatorcontrib><creatorcontrib>Gabbianelli, Rosita</creatorcontrib><creatorcontrib>Olek, Robert A.</creatorcontrib><title>Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association between TMAO and
CETP
polymorphisms (rs12720922 and rs247616), previously identified as a genetic determinant of circulating CETP, in a population of coronary artery disease (CAD) patients (n = 394) and control subjects (n = 153). We also considered age, sex, trimethylamine (TMA) levels and glomerular filtration rate (GFR) as other factors that can potentially play a role in this complex picture. We found no association of TMAO with genetically determined CETP in a population of CAD patients and control subjects. Moreover, we noticed no differences between CAD patients and control subjects in plasma TMAO levels. On the contrary, lower levels of TMA in CAD patients respect to controls were observed. Our results indicated a significant correlation between GFR and TMAO, but not TMA. The debate whether TMAO can be a harmful, diagnostic or protective marker in CVD needs to be continued.</description><subject>692/499</subject><subject>692/53</subject><subject>Aged</subject><subject>Arteriosclerosis</subject><subject>Biological Transport</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Case-Control Studies</subject><subject>Cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>Cholesterol Ester Transfer Proteins - blood</subject><subject>Cholesterol Ester Transfer Proteins - genetics</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cholesteryl ester transfer protein</subject><subject>Coronary artery</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Haplotypes</subject><subject>Heart diseases</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Macrophages</subject><subject>Male</subject><subject>Methylamines - 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Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association between TMAO and
CETP
polymorphisms (rs12720922 and rs247616), previously identified as a genetic determinant of circulating CETP, in a population of coronary artery disease (CAD) patients (n = 394) and control subjects (n = 153). We also considered age, sex, trimethylamine (TMA) levels and glomerular filtration rate (GFR) as other factors that can potentially play a role in this complex picture. We found no association of TMAO with genetically determined CETP in a population of CAD patients and control subjects. Moreover, we noticed no differences between CAD patients and control subjects in plasma TMAO levels. On the contrary, lower levels of TMA in CAD patients respect to controls were observed. Our results indicated a significant correlation between GFR and TMAO, but not TMA. The debate whether TMAO can be a harmful, diagnostic or protective marker in CVD needs to be continued.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33122777</pmid><doi>10.1038/s41598-020-75633-1</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 692/499 692/53 Aged Arteriosclerosis Biological Transport Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - metabolism Case-Control Studies Cholesterol Cholesterol - metabolism Cholesterol Ester Transfer Proteins - blood Cholesterol Ester Transfer Proteins - genetics Cholesterol, HDL - blood Cholesterol, LDL - blood Cholesteryl ester transfer protein Coronary artery Cross-Sectional Studies Female Glomerular Filtration Rate Haplotypes Heart diseases Humanities and Social Sciences Humans Macrophages Male Methylamines - metabolism Middle Aged multidisciplinary Polymorphism, Single Nucleotide Science Science (multidisciplinary) Trimethylamine |
| title | Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study |
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