Ten-eleven translocation proteins and their role beyond DNA demethylation - what we can learn from the fly
Ten-eleven Translocation (TET) proteins have emerged as a family of epigenetic regulators that are important during development and have been implicated in various types of cancers. TET is a highly conserved protein that has orthologues in almost all multicellular organisms. Here, we review recent l...
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| Veröffentlicht in: | Epigenetics 2020-11, Vol.15 (11), p.1139-1150 |
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| container_title | Epigenetics |
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| creator | Ismail, Joy N. Ghannam, Mirna Al Outa, Amani Frey, Felice Shirinian, Margret |
| description | Ten-eleven Translocation (TET) proteins have emerged as a family of epigenetic regulators that are important during development and have been implicated in various types of cancers. TET is a highly conserved protein that has orthologues in almost all multicellular organisms. Here, we review recent literature on the novel substrate specificity of this family of DNA 5-methylcytosine demethylases on DNA 6-methyladenine and RNA 5-methylcytosine that were first identified in the invertebrate model Drosophila. We focus on the biological role of these novel epigenetic marks in the fruit fly and mammals and highlight TET proteins' critical function during development specifically in brain development. |
| doi_str_mv | 10.1080/15592294.2020.1767323 |
| format | Article |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | cancer biology DNA demethylation Drosophila epigenetics neuroscience Review |
| title | Ten-eleven translocation proteins and their role beyond DNA demethylation - what we can learn from the fly |
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