A global antiB cell strategy combining obinutuzumab and daratumumab in severe pediatric nephrotic syndrome

Background Steroid-sensitive nephrotic syndrome (SSNS) is, in most patients, a chronic disease with 80% experiencing at least one relapse after first flare. B cell depletion using rituximab is effective in preventing relapse in steroid-dependent (SDNS) patients but fails to maintain long-term remiss...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2021-05, Vol.36 (5), p.1175-1182
Hauptverfasser:	Dossier, Claire, Prim, Benjamin, Moreau, Christelle, Kwon, Thérésa, Maisin, Anne, Nathanson, Sylvie, De Gennes, Christiane, Barsotti, Katia, Bourrassi, Abdelmajid, Hogan, Julien, Deschênes, Georges
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized - therapeutic use Autoimmune diseases B-Lymphocytes Cell survival Child Children Chronic illnesses Creatinine Cytotoxicity Disease Diseases Drug dosages Drug therapy Drug therapy, Combination Drug withdrawal Humans Hypogammaglobulinemia Immune Reconstitution Immunoglobulin A Immunoglobulin M Immunoglobulins Immunosuppression Immunotherapy Intravenous administration Kidney diseases Medicine Medicine & Public Health Methods Monoclonal antibodies Nephrology Nephrotic syndrome Nephrotic Syndrome - drug therapy Neutropenia Original Original Article Patient outcomes Patients Pediatric research Pediatrics Plasma Plasma cells Recovery (Medical) Recurrence Remission Rituximab Steroids Treatment Outcome Urology
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