Activity of Platinum-Based Chemotherapy in Patients With Advanced Prostate Cancer With and Without DNA Repair Gene Aberrations

DNA repair gene aberrations occur in 20% to 30% of patients with castration-resistant prostate cancer (CRPC), and some of these aberrations have been associated with sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition platinum-based treatments. However, previous trials assessing platinum-ba...

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Veröffentlicht in:	JAMA network open 2020-10, Vol.3 (10), p.e2021692-e2021692
Hauptverfasser:	Schmid, Sabine, Omlin, Aurelius, Higano, Celestia, Sweeney, Christopher, Martinez Chanza, Nieves, Mehra, Niven, Kuppen, Malou C P, Beltran, Himisha, Conteduca, Vincenza, Vargas Pivato de Almeida, Daniel, Cotait Maluf, Fernando, Oh, William K, Tsao, Che-Kai, Sartor, Oliver, Ledet, Elisa, Di Lorenzo, Giuseppe, Yip, Steven M, Chi, Kim N, Bianchini, Diletta, De Giorgi, Ugo, Hansen, Aaron R, Beer, Tomasz M, Lavaud, Pernelle, Morales-Barrera, Rafael, Tucci, Marcello, Castro, Elena, Karalis, Kostas, Bergman, Andries M, Le, Mo Linh, Zürrer-Härdi, Ursina, Pezaro, Carmel, Suzuki, Hiroyoshi, Zivi, Andrea, Klingbiel, Dirk, Schär, Sämi, Gillessen, Silke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Biomarkers Cancer therapies DNA repair DNA Repair-Deficiency Disorders - drug therapy Docetaxel - therapeutic use Drug Therapy - methods Drug Therapy - standards Drug Therapy - statistics & numerical data Humans Male Middle Aged Oncology Online Only Original Investigation Paclitaxel - therapeutic use Platinum Compounds - therapeutic use Prostate cancer Prostatic Neoplasms - therapy Retrospective Studies
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