Experimenter- and Infrared Thermography–Derived Measures of Capsaicin-Induced Neurogenic Flare Among Non-Hispanic White and Black Adults
Abstract Objective Capsaicin is a widely utilized experimental pain stimulus; however, few studies have reported on ethnic differences in pain responses to capsaicin. The present study used infrared thermography to 1) measure differences in capsaicin-induced neurogenic flare between non-Hispanic bla...
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| Veröffentlicht in: | Pain medicine (Malden, Mass.) Mass.), 2020-10, Vol.21 (10), p.2262-2270 |
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| creator | Fulton, Brook A Burton, Emily F Nance, Sabrina Letzen, Janelle E Campbell, Claudia M |
| description | Abstract
Objective
Capsaicin is a widely utilized experimental pain stimulus; however, few studies have reported on ethnic differences in pain responses to capsaicin. The present study used infrared thermography to 1) measure differences in capsaicin-induced neurogenic flare between non-Hispanic black (NHB) and non-Hispanic white (NHW) adults and 2) determine the association between neurogenic flare and secondary hyperalgesia.
Methods
Fifty-four participants (NHB N = 28) underwent heat/capsaicin sensitization model procedures. Neurogenic flare was examined using experimenter (i.e., subjective) and thermography (i.e., objective) measurements. A typically nonpainful mechanical punctate probe was used to measure secondary hyperalgesia.
Results
Ethnic groups did not significantly differ in age, sex, marital status, or personal income. Although experimenters rated a significantly wider area of capsaicin-related neurogenic flare among NHW compared with NHB participants (F1, 52 = 8.33, P = 0.006), thermography results showed no differences between groups in neurogenic flares (F1, 52 = 0.01, P = 0.93). Further, although NHB individuals reported greater average pain during the capsaicin procedures compared with NHW individuals (NHB = 58.57 [3.67], NHW = 46.46 [3.81]; F2, 51 = 5.19, P = 0.03), the groups did not differ in secondary hyperalgesia (F2, 51 = 0.03, P = 0.86), and ethnicity did not moderate the association between neurogenic flare and secondary hyperalgesia (F3, 50 = 0.24, P = 0.87).
Conclusions
Findings cautiously support the use of infrared thermography over subjective experimenter report when measuring neurogenic inflammation in diverse samples. However, infrared thermography should not be used as a diagnostic tool for pain, given the lack of association between these factors. Future research is warranted to replicate these findings in a larger and more diverse sample to determine accurate neurogenic inflammation measures across other ethnic minority populations. |
| doi_str_mv | 10.1093/pm/pnaa006 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7593802</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A700452428</galeid><oup_id>10.1093/pm/pnaa006</oup_id><sourcerecordid>A700452428</sourcerecordid><originalsourceid>FETCH-LOGICAL-c392t-b7b2c6482e81a3c3cbe1a2e464dfc8e5744849f0178e9212d240cd95eef1aa13</originalsourceid><addsrcrecordid>eNp9kk1rFEEQhgdRzIde_AEyIEIQJumv-boI65qYhRgvCx6b2p6a2Y4z3Z3umWBunr36D_0l9rprSESkD91UPfUWb3UlyQtKjimp-YkbTpwBIKR4lOzTnBWZKHj5ePdmvMz3koMQrgihhaj402SPMyoYzel-8v30q0OvBzQj-iwF06QL03rw2KTLNfrBdh7c-vbntx_vI3cTwx8RwuQxpLZN5-ACaKVNtjDNpGL2EidvOzRapWd9lElngzVdemlNdq6Dg03i81qP-LvXux7Ul3TWTP0YniVPWugDPt_dh8ny7HQ5P88uPn1YzGcXmeI1G7NVuWIq-mBYUeCKqxVSYCgK0bSqwrwUohJ1S2hZYc0oa5ggqqlzxJYCUH6YvN3Kumk1YKOicw-9dHEI4G-lBS0fZoxey87eyDKveUVYFDjaCXh7PWEY5aCDwr4Hg3YKMg5ccE4IyyP66i_0yk7eRHeSiTJ-TJGX96gOepTatDb2VRtROSsJETkTrIrU8T-oeBoctLIGWx3jDwrebAuUtyF4bO88UiI3iyPdIHeLE-GX96dyh_7ZlAi83gJ2cv8T-gWCrc1M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473756575</pqid></control><display><type>article</type><title>Experimenter- and Infrared Thermography–Derived Measures of Capsaicin-Induced Neurogenic Flare Among Non-Hispanic White and Black Adults</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Fulton, Brook A ; Burton, Emily F ; Nance, Sabrina ; Letzen, Janelle E ; Campbell, Claudia M</creator><creatorcontrib>Fulton, Brook A ; Burton, Emily F ; Nance, Sabrina ; Letzen, Janelle E ; Campbell, Claudia M</creatorcontrib><description>Abstract
Objective
Capsaicin is a widely utilized experimental pain stimulus; however, few studies have reported on ethnic differences in pain responses to capsaicin. The present study used infrared thermography to 1) measure differences in capsaicin-induced neurogenic flare between non-Hispanic black (NHB) and non-Hispanic white (NHW) adults and 2) determine the association between neurogenic flare and secondary hyperalgesia.
Methods
Fifty-four participants (NHB N = 28) underwent heat/capsaicin sensitization model procedures. Neurogenic flare was examined using experimenter (i.e., subjective) and thermography (i.e., objective) measurements. A typically nonpainful mechanical punctate probe was used to measure secondary hyperalgesia.
Results
Ethnic groups did not significantly differ in age, sex, marital status, or personal income. Although experimenters rated a significantly wider area of capsaicin-related neurogenic flare among NHW compared with NHB participants (F1, 52 = 8.33, P = 0.006), thermography results showed no differences between groups in neurogenic flares (F1, 52 = 0.01, P = 0.93). Further, although NHB individuals reported greater average pain during the capsaicin procedures compared with NHW individuals (NHB = 58.57 [3.67], NHW = 46.46 [3.81]; F2, 51 = 5.19, P = 0.03), the groups did not differ in secondary hyperalgesia (F2, 51 = 0.03, P = 0.86), and ethnicity did not moderate the association between neurogenic flare and secondary hyperalgesia (F3, 50 = 0.24, P = 0.87).
Conclusions
Findings cautiously support the use of infrared thermography over subjective experimenter report when measuring neurogenic inflammation in diverse samples. However, infrared thermography should not be used as a diagnostic tool for pain, given the lack of association between these factors. Future research is warranted to replicate these findings in a larger and more diverse sample to determine accurate neurogenic inflammation measures across other ethnic minority populations.</description><identifier>ISSN: 1526-2375</identifier><identifier>EISSN: 1526-4637</identifier><identifier>DOI: 10.1093/pm/pnaa006</identifier><identifier>PMID: 32142151</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; African Americans ; Blacks ; Capsaicin ; Comparative analysis ; Demographic aspects ; Development and progression ; Ethnic Groups ; Ethnicity ; Health aspects ; Hispanic Americans ; Humans ; Hyperalgesia ; Hyperalgesia - chemically induced ; Inflammation ; Methodology, Mechanisms & Translational Research Section ; Minority & ethnic groups ; Minority Groups ; Nerves ; Pain ; Pain perception ; Physiological aspects ; Testing ; Thermography ; Whites</subject><ispartof>Pain medicine (Malden, Mass.), 2020-10, Vol.21 (10), p.2262-2270</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the American Academy of Pain Medicine.All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the American Academy of Pain Medicine.All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the American Academy of Pain Medicine.All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c392t-b7b2c6482e81a3c3cbe1a2e464dfc8e5744849f0178e9212d240cd95eef1aa13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32142151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fulton, Brook A</creatorcontrib><creatorcontrib>Burton, Emily F</creatorcontrib><creatorcontrib>Nance, Sabrina</creatorcontrib><creatorcontrib>Letzen, Janelle E</creatorcontrib><creatorcontrib>Campbell, Claudia M</creatorcontrib><title>Experimenter- and Infrared Thermography–Derived Measures of Capsaicin-Induced Neurogenic Flare Among Non-Hispanic White and Black Adults</title><title>Pain medicine (Malden, Mass.)</title><addtitle>Pain Med</addtitle><description>Abstract
Objective
Capsaicin is a widely utilized experimental pain stimulus; however, few studies have reported on ethnic differences in pain responses to capsaicin. The present study used infrared thermography to 1) measure differences in capsaicin-induced neurogenic flare between non-Hispanic black (NHB) and non-Hispanic white (NHW) adults and 2) determine the association between neurogenic flare and secondary hyperalgesia.
Methods
Fifty-four participants (NHB N = 28) underwent heat/capsaicin sensitization model procedures. Neurogenic flare was examined using experimenter (i.e., subjective) and thermography (i.e., objective) measurements. A typically nonpainful mechanical punctate probe was used to measure secondary hyperalgesia.
Results
Ethnic groups did not significantly differ in age, sex, marital status, or personal income. Although experimenters rated a significantly wider area of capsaicin-related neurogenic flare among NHW compared with NHB participants (F1, 52 = 8.33, P = 0.006), thermography results showed no differences between groups in neurogenic flares (F1, 52 = 0.01, P = 0.93). Further, although NHB individuals reported greater average pain during the capsaicin procedures compared with NHW individuals (NHB = 58.57 [3.67], NHW = 46.46 [3.81]; F2, 51 = 5.19, P = 0.03), the groups did not differ in secondary hyperalgesia (F2, 51 = 0.03, P = 0.86), and ethnicity did not moderate the association between neurogenic flare and secondary hyperalgesia (F3, 50 = 0.24, P = 0.87).
Conclusions
Findings cautiously support the use of infrared thermography over subjective experimenter report when measuring neurogenic inflammation in diverse samples. However, infrared thermography should not be used as a diagnostic tool for pain, given the lack of association between these factors. Future research is warranted to replicate these findings in a larger and more diverse sample to determine accurate neurogenic inflammation measures across other ethnic minority populations.</description><subject>Adult</subject><subject>African Americans</subject><subject>Blacks</subject><subject>Capsaicin</subject><subject>Comparative analysis</subject><subject>Demographic aspects</subject><subject>Development and progression</subject><subject>Ethnic Groups</subject><subject>Ethnicity</subject><subject>Health aspects</subject><subject>Hispanic Americans</subject><subject>Humans</subject><subject>Hyperalgesia</subject><subject>Hyperalgesia - chemically induced</subject><subject>Inflammation</subject><subject>Methodology, Mechanisms & Translational Research Section</subject><subject>Minority & ethnic groups</subject><subject>Minority Groups</subject><subject>Nerves</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Physiological aspects</subject><subject>Testing</subject><subject>Thermography</subject><subject>Whites</subject><issn>1526-2375</issn><issn>1526-4637</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk1rFEEQhgdRzIde_AEyIEIQJumv-boI65qYhRgvCx6b2p6a2Y4z3Z3umWBunr36D_0l9rprSESkD91UPfUWb3UlyQtKjimp-YkbTpwBIKR4lOzTnBWZKHj5ePdmvMz3koMQrgihhaj402SPMyoYzel-8v30q0OvBzQj-iwF06QL03rw2KTLNfrBdh7c-vbntx_vI3cTwx8RwuQxpLZN5-ACaKVNtjDNpGL2EidvOzRapWd9lElngzVdemlNdq6Dg03i81qP-LvXux7Ul3TWTP0YniVPWugDPt_dh8ny7HQ5P88uPn1YzGcXmeI1G7NVuWIq-mBYUeCKqxVSYCgK0bSqwrwUohJ1S2hZYc0oa5ggqqlzxJYCUH6YvN3Kumk1YKOicw-9dHEI4G-lBS0fZoxey87eyDKveUVYFDjaCXh7PWEY5aCDwr4Hg3YKMg5ccE4IyyP66i_0yk7eRHeSiTJ-TJGX96gOepTatDb2VRtROSsJETkTrIrU8T-oeBoctLIGWx3jDwrebAuUtyF4bO88UiI3iyPdIHeLE-GX96dyh_7ZlAi83gJ2cv8T-gWCrc1M</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Fulton, Brook A</creator><creator>Burton, Emily F</creator><creator>Nance, Sabrina</creator><creator>Letzen, Janelle E</creator><creator>Campbell, Claudia M</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201001</creationdate><title>Experimenter- and Infrared Thermography–Derived Measures of Capsaicin-Induced Neurogenic Flare Among Non-Hispanic White and Black Adults</title><author>Fulton, Brook A ; Burton, Emily F ; Nance, Sabrina ; Letzen, Janelle E ; Campbell, Claudia M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-b7b2c6482e81a3c3cbe1a2e464dfc8e5744849f0178e9212d240cd95eef1aa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>African Americans</topic><topic>Blacks</topic><topic>Capsaicin</topic><topic>Comparative analysis</topic><topic>Demographic aspects</topic><topic>Development and progression</topic><topic>Ethnic Groups</topic><topic>Ethnicity</topic><topic>Health aspects</topic><topic>Hispanic Americans</topic><topic>Humans</topic><topic>Hyperalgesia</topic><topic>Hyperalgesia - chemically induced</topic><topic>Inflammation</topic><topic>Methodology, Mechanisms & Translational Research Section</topic><topic>Minority & ethnic groups</topic><topic>Minority Groups</topic><topic>Nerves</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Physiological aspects</topic><topic>Testing</topic><topic>Thermography</topic><topic>Whites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fulton, Brook A</creatorcontrib><creatorcontrib>Burton, Emily F</creatorcontrib><creatorcontrib>Nance, Sabrina</creatorcontrib><creatorcontrib>Letzen, Janelle E</creatorcontrib><creatorcontrib>Campbell, Claudia M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pain medicine (Malden, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fulton, Brook A</au><au>Burton, Emily F</au><au>Nance, Sabrina</au><au>Letzen, Janelle E</au><au>Campbell, Claudia M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimenter- and Infrared Thermography–Derived Measures of Capsaicin-Induced Neurogenic Flare Among Non-Hispanic White and Black Adults</atitle><jtitle>Pain medicine (Malden, Mass.)</jtitle><addtitle>Pain Med</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>21</volume><issue>10</issue><spage>2262</spage><epage>2270</epage><pages>2262-2270</pages><issn>1526-2375</issn><eissn>1526-4637</eissn><abstract>Abstract
Objective
Capsaicin is a widely utilized experimental pain stimulus; however, few studies have reported on ethnic differences in pain responses to capsaicin. The present study used infrared thermography to 1) measure differences in capsaicin-induced neurogenic flare between non-Hispanic black (NHB) and non-Hispanic white (NHW) adults and 2) determine the association between neurogenic flare and secondary hyperalgesia.
Methods
Fifty-four participants (NHB N = 28) underwent heat/capsaicin sensitization model procedures. Neurogenic flare was examined using experimenter (i.e., subjective) and thermography (i.e., objective) measurements. A typically nonpainful mechanical punctate probe was used to measure secondary hyperalgesia.
Results
Ethnic groups did not significantly differ in age, sex, marital status, or personal income. Although experimenters rated a significantly wider area of capsaicin-related neurogenic flare among NHW compared with NHB participants (F1, 52 = 8.33, P = 0.006), thermography results showed no differences between groups in neurogenic flares (F1, 52 = 0.01, P = 0.93). Further, although NHB individuals reported greater average pain during the capsaicin procedures compared with NHW individuals (NHB = 58.57 [3.67], NHW = 46.46 [3.81]; F2, 51 = 5.19, P = 0.03), the groups did not differ in secondary hyperalgesia (F2, 51 = 0.03, P = 0.86), and ethnicity did not moderate the association between neurogenic flare and secondary hyperalgesia (F3, 50 = 0.24, P = 0.87).
Conclusions
Findings cautiously support the use of infrared thermography over subjective experimenter report when measuring neurogenic inflammation in diverse samples. However, infrared thermography should not be used as a diagnostic tool for pain, given the lack of association between these factors. Future research is warranted to replicate these findings in a larger and more diverse sample to determine accurate neurogenic inflammation measures across other ethnic minority populations.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32142151</pmid><doi>10.1093/pm/pnaa006</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult African Americans Blacks Capsaicin Comparative analysis Demographic aspects Development and progression Ethnic Groups Ethnicity Health aspects Hispanic Americans Humans Hyperalgesia Hyperalgesia - chemically induced Inflammation Methodology, Mechanisms & Translational Research Section Minority & ethnic groups Minority Groups Nerves Pain Pain perception Physiological aspects Testing Thermography Whites |
| title | Experimenter- and Infrared Thermography–Derived Measures of Capsaicin-Induced Neurogenic Flare Among Non-Hispanic White and Black Adults |
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