A phase 2 basket trial of combination therapy with trastuzumab and pertuzumab in patients with solid cancers harboring human epidermal growth factor receptor 2 amplification (JUPITER trial)

Human epidermal growth factor receptor 2 (HER2) gene amplification and mutations have emerged as oncogenic drivers and therapeutic targets not limited to breast and gastric cancers, but also in a variety of cancers. However, even if an actionable gene alteration is found, the incidence of HER2 ampli...

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Veröffentlicht in:	Medicine (Baltimore) 2020-08, Vol.99 (32), p.e21457-e21457
Hauptverfasser:	Takahashi, Kenta, Ishibashi, Eri, Kubo, Toshio, Harada, Yohei, Hayashi, Hideyuki, Kano, Masayuki, Shimizu, Yasushi, Shirota, Hidekazu, Mori, Yukiko, Muto, Manabu, Ishioka, Chikashi, Dosaka-Akita, Hirotoshi, Matsubara, Hisahiro, Nishihara, Hiroshi, Sueoka-Aragane, Naoko, Toyooka, Shinichi, Hirakawa, Akihiro, Tateishi, Ukihide, Miyake, Satoshi, Ikeda, Sadakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents, Immunological - therapeutic use Clinical Trials, Phase II as Topic Drug Therapy, Combination Humans Japan Multicenter Studies as Topic Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Receptor, ErbB-2 - genetics Study Protocol Clinical Trial Trastuzumab - therapeutic use
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