GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain

Neuropathic pain is a debilitating public health concern for which novel non-narcotic therapeutic targets are desperately needed. Using unbiased transcriptomic screening of the dorsal horn spinal cord after nerve injury we have identified that Gpr183 (Epstein-Barr virus–induced gene 2) is upregulate...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2020-11, Vol.375 (2), p.367-375
Hauptverfasser:	Braden, Kathryn, Giancotti, Luigino Antonio, Chen, Zhoumou, DeLeon, Chelsea, Latzo, Nick, Boehm, Terri, D’Cunha, Napoleon, Thompson, Bonne M., Doyle, Timothy M., McDonald, Jeffrey G., Walker, John K., Kolar, Grant R., Arnatt, Christopher Kent, Salvemini, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Discovery and Translational Medicine Female HL-60 Cells Humans Male Mice Neuralgia - drug therapy Neuralgia - metabolism Neuralgia - pathology Oxysterols - metabolism Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - metabolism Signal Transduction Spinal Cord - metabolism Spinal Cord - pathology
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