Biexponential T1ρ relaxation mapping of human knee menisci
Background Measuring T1ρ in the knee menisci can potentially be used as noninvasive biomarkers in detecting early‐stage osteoarthritis (OA). Purpose To demonstrate the feasibility of biexponential T1ρ relaxation mapping of human knee menisci. Study Type Prospective. Population Eight healthy voluntee...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2019-09, Vol.50 (3), p.824-835 |
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| creator | Baboli, Rahman Sharafi, Azadeh Chang, Gregory Regatte, Ravinder R. |
| description | Background
Measuring T1ρ in the knee menisci can potentially be used as noninvasive biomarkers in detecting early‐stage osteoarthritis (OA).
Purpose
To demonstrate the feasibility of biexponential T1ρ relaxation mapping of human knee menisci.
Study Type
Prospective.
Population
Eight healthy volunteers with no known inflammation, trauma, or pain in the knee and three symptomatic subjects with early knee OA.
Field Strength/Sequence
Customized Turbo‐FLASH sequence to acquire 3D‐T1ρ‐weighted images on a 3 T MRI scanner.
Assessment
T1ρ relaxation values were assessed in 11 meniscal regions of interest (ROIs) using monoexponential and biexponential models.
Statistical Tests
Nonparametric rank‐sum tests, Kruskal–Wallis test, and coefficient of variation.
Results
The mean monoexponential T1ρ relaxation in the lateral menisci were 28.05 ± 4.2 msec and 37.06 ± 10.64 msec for healthy subjects and early knee OA patients, respectively, while the short and long components were 8.07 ± 0.5 msec and 72.35 ± 3.2 msec for healthy subjects and 2.63 ± 2.99 msec and 55.27 ± 24.76 msec for early knee OA patients, respectively. The mean monoexponential T1ρ relaxation in the medial menisci were 34.30 ± 3.8 msec and 37.26 ± 11.38 msec for healthy and OA patients, respectively, while the short and long components were 7.76 ± 0.7 msec and 72.19 ± 4.2 msec for healthy subjects and 3.06 ± 3.24 msec and 55.27 ± 24.59 msec for OA patients, respectively. Statistically significant (P ≤ 0.05) differences were observed in the monoexponential relaxation between some of the ROIs. The T1ρ,short was significantly lower (P = 0.02) in the patients than controls. The rmsCV% ranges were 1.51–16.6%, 3.59–14.3%, and 4.91–15.6% for T1ρ‐mono, T1ρ‐short, and T1ρ‐long, respectively.
Data Conclusion
Our results showed that in all ROIs, T1ρ relaxation times of outer zones (red zones) were less than inner zones (white zones). Monoexponential T1ρ was increased in medial, lateral, and body menisci of early OA while the biexponential numbers were decreased in early OA patients.
Level of Evidence: 2
Technical Efficacy Stage: 1
J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2019;50:824–835. |
| doi_str_mv | 10.1002/jmri.26631 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7592083</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2272173018</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2641-b32c8881434be2d6727a4a140d72e39d0c71eb256615146169cafaebe76727be3</originalsourceid><addsrcrecordid>eNpdkc1Kw0AUhQdRbK1ufIKAGzepc2cmMwmCoMWfSkWQuh4m6W07NZnEpNF26RP6SiZtEXR1D9yPwzkcQk6B9oFSdrHISttnUnLYI10IGPNZEMr9RtOA-xBS1SFHVbWglEaRCA5Jh1MJoiG75PLG4qrIHbqlNak3hu8vr8TUrMzS5s7LTFFYN_PyqTevM-O8N4foZehsldhjcjA1aYUnu9sjr3e348GDP3q-Hw6uR37BpAA_5iwJwxAEFzGyiVRMGWFA0IliyKMJTRRgzAIpIQAhQUaJmRqMUbVojLxHrra-RR1nOEmarKVJdVHazJRrnRur_36cnetZ_qFVEDEa8sbgfGdQ5u81VkudNfkxTY3DvK40AykCIUNo0bN_6CKvS9fU04wpBopTCBsKttSnTXH9mwSobgfR7SB6M4h-fHoZbhT_AclZfrw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2272173018</pqid></control><display><type>article</type><title>Biexponential T1ρ relaxation mapping of human knee menisci</title><source>Wiley Free Content</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Baboli, Rahman ; Sharafi, Azadeh ; Chang, Gregory ; Regatte, Ravinder R.</creator><creatorcontrib>Baboli, Rahman ; Sharafi, Azadeh ; Chang, Gregory ; Regatte, Ravinder R.</creatorcontrib><description>Background
Measuring T1ρ in the knee menisci can potentially be used as noninvasive biomarkers in detecting early‐stage osteoarthritis (OA).
Purpose
To demonstrate the feasibility of biexponential T1ρ relaxation mapping of human knee menisci.
Study Type
Prospective.
Population
Eight healthy volunteers with no known inflammation, trauma, or pain in the knee and three symptomatic subjects with early knee OA.
Field Strength/Sequence
Customized Turbo‐FLASH sequence to acquire 3D‐T1ρ‐weighted images on a 3 T MRI scanner.
Assessment
T1ρ relaxation values were assessed in 11 meniscal regions of interest (ROIs) using monoexponential and biexponential models.
Statistical Tests
Nonparametric rank‐sum tests, Kruskal–Wallis test, and coefficient of variation.
Results
The mean monoexponential T1ρ relaxation in the lateral menisci were 28.05 ± 4.2 msec and 37.06 ± 10.64 msec for healthy subjects and early knee OA patients, respectively, while the short and long components were 8.07 ± 0.5 msec and 72.35 ± 3.2 msec for healthy subjects and 2.63 ± 2.99 msec and 55.27 ± 24.76 msec for early knee OA patients, respectively. The mean monoexponential T1ρ relaxation in the medial menisci were 34.30 ± 3.8 msec and 37.26 ± 11.38 msec for healthy and OA patients, respectively, while the short and long components were 7.76 ± 0.7 msec and 72.19 ± 4.2 msec for healthy subjects and 3.06 ± 3.24 msec and 55.27 ± 24.59 msec for OA patients, respectively. Statistically significant (P ≤ 0.05) differences were observed in the monoexponential relaxation between some of the ROIs. The T1ρ,short was significantly lower (P = 0.02) in the patients than controls. The rmsCV% ranges were 1.51–16.6%, 3.59–14.3%, and 4.91–15.6% for T1ρ‐mono, T1ρ‐short, and T1ρ‐long, respectively.
Data Conclusion
Our results showed that in all ROIs, T1ρ relaxation times of outer zones (red zones) were less than inner zones (white zones). Monoexponential T1ρ was increased in medial, lateral, and body menisci of early OA while the biexponential numbers were decreased in early OA patients.
Level of Evidence: 2
Technical Efficacy Stage: 1
J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2019;50:824–835.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.26631</identifier><identifier>PMID: 30614152</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>bicomponent T1ρ relaxation ; biexponential and monoexponential T1ρ ; Biomarkers ; Biomedical materials ; Coefficient of variation ; Feasibility studies ; Field strength ; Image acquisition ; Knee ; knee menisci ; Magnetic resonance imaging ; Mapping ; Mathematical models ; Medical imaging ; Meniscus ; Osteoarthritis ; Pain ; Population (statistical) ; Population studies ; Statistical analysis ; Statistical tests ; Trauma</subject><ispartof>Journal of magnetic resonance imaging, 2019-09, Vol.50 (3), p.824-835</ispartof><rights>2019 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-9572-4922</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.26631$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.26631$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids></links><search><creatorcontrib>Baboli, Rahman</creatorcontrib><creatorcontrib>Sharafi, Azadeh</creatorcontrib><creatorcontrib>Chang, Gregory</creatorcontrib><creatorcontrib>Regatte, Ravinder R.</creatorcontrib><title>Biexponential T1ρ relaxation mapping of human knee menisci</title><title>Journal of magnetic resonance imaging</title><description>Background
Measuring T1ρ in the knee menisci can potentially be used as noninvasive biomarkers in detecting early‐stage osteoarthritis (OA).
Purpose
To demonstrate the feasibility of biexponential T1ρ relaxation mapping of human knee menisci.
Study Type
Prospective.
Population
Eight healthy volunteers with no known inflammation, trauma, or pain in the knee and three symptomatic subjects with early knee OA.
Field Strength/Sequence
Customized Turbo‐FLASH sequence to acquire 3D‐T1ρ‐weighted images on a 3 T MRI scanner.
Assessment
T1ρ relaxation values were assessed in 11 meniscal regions of interest (ROIs) using monoexponential and biexponential models.
Statistical Tests
Nonparametric rank‐sum tests, Kruskal–Wallis test, and coefficient of variation.
Results
The mean monoexponential T1ρ relaxation in the lateral menisci were 28.05 ± 4.2 msec and 37.06 ± 10.64 msec for healthy subjects and early knee OA patients, respectively, while the short and long components were 8.07 ± 0.5 msec and 72.35 ± 3.2 msec for healthy subjects and 2.63 ± 2.99 msec and 55.27 ± 24.76 msec for early knee OA patients, respectively. The mean monoexponential T1ρ relaxation in the medial menisci were 34.30 ± 3.8 msec and 37.26 ± 11.38 msec for healthy and OA patients, respectively, while the short and long components were 7.76 ± 0.7 msec and 72.19 ± 4.2 msec for healthy subjects and 3.06 ± 3.24 msec and 55.27 ± 24.59 msec for OA patients, respectively. Statistically significant (P ≤ 0.05) differences were observed in the monoexponential relaxation between some of the ROIs. The T1ρ,short was significantly lower (P = 0.02) in the patients than controls. The rmsCV% ranges were 1.51–16.6%, 3.59–14.3%, and 4.91–15.6% for T1ρ‐mono, T1ρ‐short, and T1ρ‐long, respectively.
Data Conclusion
Our results showed that in all ROIs, T1ρ relaxation times of outer zones (red zones) were less than inner zones (white zones). Monoexponential T1ρ was increased in medial, lateral, and body menisci of early OA while the biexponential numbers were decreased in early OA patients.
Level of Evidence: 2
Technical Efficacy Stage: 1
J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2019;50:824–835.</description><subject>bicomponent T1ρ relaxation</subject><subject>biexponential and monoexponential T1ρ</subject><subject>Biomarkers</subject><subject>Biomedical materials</subject><subject>Coefficient of variation</subject><subject>Feasibility studies</subject><subject>Field strength</subject><subject>Image acquisition</subject><subject>Knee</subject><subject>knee menisci</subject><subject>Magnetic resonance imaging</subject><subject>Mapping</subject><subject>Mathematical models</subject><subject>Medical imaging</subject><subject>Meniscus</subject><subject>Osteoarthritis</subject><subject>Pain</subject><subject>Population (statistical)</subject><subject>Population studies</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Trauma</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkc1Kw0AUhQdRbK1ufIKAGzepc2cmMwmCoMWfSkWQuh4m6W07NZnEpNF26RP6SiZtEXR1D9yPwzkcQk6B9oFSdrHISttnUnLYI10IGPNZEMr9RtOA-xBS1SFHVbWglEaRCA5Jh1MJoiG75PLG4qrIHbqlNak3hu8vr8TUrMzS5s7LTFFYN_PyqTevM-O8N4foZehsldhjcjA1aYUnu9sjr3e348GDP3q-Hw6uR37BpAA_5iwJwxAEFzGyiVRMGWFA0IliyKMJTRRgzAIpIQAhQUaJmRqMUbVojLxHrra-RR1nOEmarKVJdVHazJRrnRur_36cnetZ_qFVEDEa8sbgfGdQ5u81VkudNfkxTY3DvK40AykCIUNo0bN_6CKvS9fU04wpBopTCBsKttSnTXH9mwSobgfR7SB6M4h-fHoZbhT_AclZfrw</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Baboli, Rahman</creator><creator>Sharafi, Azadeh</creator><creator>Chang, Gregory</creator><creator>Regatte, Ravinder R.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9572-4922</orcidid></search><sort><creationdate>201909</creationdate><title>Biexponential T1ρ relaxation mapping of human knee menisci</title><author>Baboli, Rahman ; Sharafi, Azadeh ; Chang, Gregory ; Regatte, Ravinder R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2641-b32c8881434be2d6727a4a140d72e39d0c71eb256615146169cafaebe76727be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>bicomponent T1ρ relaxation</topic><topic>biexponential and monoexponential T1ρ</topic><topic>Biomarkers</topic><topic>Biomedical materials</topic><topic>Coefficient of variation</topic><topic>Feasibility studies</topic><topic>Field strength</topic><topic>Image acquisition</topic><topic>Knee</topic><topic>knee menisci</topic><topic>Magnetic resonance imaging</topic><topic>Mapping</topic><topic>Mathematical models</topic><topic>Medical imaging</topic><topic>Meniscus</topic><topic>Osteoarthritis</topic><topic>Pain</topic><topic>Population (statistical)</topic><topic>Population studies</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baboli, Rahman</creatorcontrib><creatorcontrib>Sharafi, Azadeh</creatorcontrib><creatorcontrib>Chang, Gregory</creatorcontrib><creatorcontrib>Regatte, Ravinder R.</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baboli, Rahman</au><au>Sharafi, Azadeh</au><au>Chang, Gregory</au><au>Regatte, Ravinder R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biexponential T1ρ relaxation mapping of human knee menisci</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><date>2019-09</date><risdate>2019</risdate><volume>50</volume><issue>3</issue><spage>824</spage><epage>835</epage><pages>824-835</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Background
Measuring T1ρ in the knee menisci can potentially be used as noninvasive biomarkers in detecting early‐stage osteoarthritis (OA).
Purpose
To demonstrate the feasibility of biexponential T1ρ relaxation mapping of human knee menisci.
Study Type
Prospective.
Population
Eight healthy volunteers with no known inflammation, trauma, or pain in the knee and three symptomatic subjects with early knee OA.
Field Strength/Sequence
Customized Turbo‐FLASH sequence to acquire 3D‐T1ρ‐weighted images on a 3 T MRI scanner.
Assessment
T1ρ relaxation values were assessed in 11 meniscal regions of interest (ROIs) using monoexponential and biexponential models.
Statistical Tests
Nonparametric rank‐sum tests, Kruskal–Wallis test, and coefficient of variation.
Results
The mean monoexponential T1ρ relaxation in the lateral menisci were 28.05 ± 4.2 msec and 37.06 ± 10.64 msec for healthy subjects and early knee OA patients, respectively, while the short and long components were 8.07 ± 0.5 msec and 72.35 ± 3.2 msec for healthy subjects and 2.63 ± 2.99 msec and 55.27 ± 24.76 msec for early knee OA patients, respectively. The mean monoexponential T1ρ relaxation in the medial menisci were 34.30 ± 3.8 msec and 37.26 ± 11.38 msec for healthy and OA patients, respectively, while the short and long components were 7.76 ± 0.7 msec and 72.19 ± 4.2 msec for healthy subjects and 3.06 ± 3.24 msec and 55.27 ± 24.59 msec for OA patients, respectively. Statistically significant (P ≤ 0.05) differences were observed in the monoexponential relaxation between some of the ROIs. The T1ρ,short was significantly lower (P = 0.02) in the patients than controls. The rmsCV% ranges were 1.51–16.6%, 3.59–14.3%, and 4.91–15.6% for T1ρ‐mono, T1ρ‐short, and T1ρ‐long, respectively.
Data Conclusion
Our results showed that in all ROIs, T1ρ relaxation times of outer zones (red zones) were less than inner zones (white zones). Monoexponential T1ρ was increased in medial, lateral, and body menisci of early OA while the biexponential numbers were decreased in early OA patients.
Level of Evidence: 2
Technical Efficacy Stage: 1
J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2019;50:824–835.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30614152</pmid><doi>10.1002/jmri.26631</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9572-4922</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | bicomponent T1ρ relaxation biexponential and monoexponential T1ρ Biomarkers Biomedical materials Coefficient of variation Feasibility studies Field strength Image acquisition Knee knee menisci Magnetic resonance imaging Mapping Mathematical models Medical imaging Meniscus Osteoarthritis Pain Population (statistical) Population studies Statistical analysis Statistical tests Trauma |
| title | Biexponential T1ρ relaxation mapping of human knee menisci |
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