Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling

Doxorubicin (DOX) is an effective anticancer drug, but its therapeutic use is limited by its cardiotoxicity. The principal mechanisms of DOX-induced cardiotoxicity are oxidative stress and apoptosis in cardiomyocytes. Orosomucoid 1 (ORM1), an acute-phase protein, plays important roles in inflammatio...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020 (2020), p.1-13
Hauptverfasser:	Han, Yaling, Tian, Xiaoxiang, Song, Haixu, Xing, Ruinan, Liu, Dan, Cheng, Xiaoli, Yan, Chenghui
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal Acute phase proteins Aldehydes - metabolism Analysis Animal models Animals Antibiotics Anticancer properties Antioxidants Apoptosis Apoptosis - drug effects Apoptosis - physiology Cancer therapies Cardiomyocytes Cardiotoxicity Cardiotoxicity - metabolism Cardiovascular disease Caspase 3 - metabolism Caspase-3 Cell Line Dosage and administration Doxorubicin Doxorubicin - adverse effects Enzymes Experiments Glycoproteins Heart cells Heart failure Heme Heme Oxygenase-1 - metabolism Identification and classification Inflammation - metabolism Ischemia Kinases Laboratory animals Lipid peroxidation Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Lipids Lymphoma Male Mice Mice, Inbred C57BL Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism NF-E2-Related Factor 2 - metabolism Orosomucoid - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Oxygenase Peroxidation Properties Proteins Quality of life Rats Signal Transduction - drug effects Signal Transduction - physiology
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