Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice

Medium-chain triglycerides (MCT), containing C 8 –C 12 fatty acids, are used to treat several pediatric disorders and are widely consumed as a nutritional supplement. Here, we investigated the role of the sirtuin deacylase Sirt5 in MCT metabolism by feeding Sirt5 knockout mice (Sirt5KO) high-fat die...

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Veröffentlicht in:	Scientific reports 2020-10, Vol.10 (1), p.18367-18367, Article 18367
Hauptverfasser:	Goetzman, Eric S., Bharathi, Sivakama S., Zhang, Yuxun, Zhao, Xue-Jun, Dobrowolski, Steven F., Peasley, Kevin, Sims-Lucas, Sunder, Monga, Satdarshan P.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443 631/45 692/4017 Acyl-CoA dehydrogenase Acyl-CoA Dehydrogenase, Long-Chain - metabolism Animals Coconut oil Coconut Oil - administration & dosage Dietary Fats - administration & dosage Endoplasmic reticulum Fatty acids Fatty Acids - metabolism Fatty liver Female High fat diet Humanities and Social Sciences Liver Liver diseases Male Mice Mice, Knockout Mitochondria Mitochondria, Liver - metabolism multidisciplinary Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Oxidation Oxidation-Reduction Pediatrics Phenotypes Science Science (multidisciplinary) Sirtuins - genetics Steatosis Triglycerides Triglycerides - metabolism
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