E2F7−EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression

Background E2F transcription factors are considered to be important drivers of tumour growth. E2F7 is an atypical E2F factor, and its role in glioblastoma remains undefined. Methods E2F7 expression was examined in patients by IHC and qRT-PCR. The overall survival probability was determined by statis...

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Veröffentlicht in:	British journal of cancer 2020-10, Vol.123 (9), p.1445-1455
Hauptverfasser:	Yang, Rui, Wang, Mei, Zhang, Guanghui, Bao, Yonghua, Wu, Yanan, Li, Xiuxiu, Yang, Wancai, Cui, Hongjuan
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028/67/1857 692/4028/67/1922 AKT protein Animals Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer Research Cell growth Cell proliferation Cell Proliferation - genetics Cells, Cultured Chromatin Disease Progression Drug Resistance E2F protein E2F7 Transcription Factor - physiology Enhancer of Zeste Homolog 2 Protein - physiology Epidemiology Gene Expression Regulation, Neoplastic Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology HEK293 Cells Humans Immunoprecipitation Kinases Male Metastases Metastasis Mice Mice, Nude Molecular Medicine Neoplasm Metastasis Oncology Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein Signal transduction Signal Transduction - physiology Statistical analysis TOR protein TOR Serine-Threonine Kinases - metabolism Transcription factors Tumorigenesis Tumorigenicity Tumors
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