A role for the immune system in advanced laryngeal cancer
To investigate the role of the altered activation of the immune system in the prognosis of patients affected by laryngeal squamous cell carcinoma (LSCC). We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after t...
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| Veröffentlicht in: | Scientific reports 2020-10, Vol.10 (1), p.18327, Article 18327 |
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| creator | Tagliabue, Marta Maffini, Fausto Fumagalli, Caterina Gandini, Sara Lepanto, Daniela Corso, Federica Cacciola, Salvatore Ranghiero, Alberto Rappa, Alessandra Vacirca, Davide Cossu Rocca, Maria Alterio, Daniela Guerini Rocco, Elena Cattaneo, Augusto Chu, Francesco Zorzi, Stefano Curigliano, Giuseppe Chiocca, Susanna Barberis, Massimo Viale, Giuseppe Ansarin, Mohssen |
| description | To investigate the role of the altered activation of the immune system in the prognosis of patients affected by laryngeal squamous cell carcinoma (LSCC). We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the second group had no evidence of disease at 2 years. The presence of stromal tumor infiltrating lymphocytes (TILs) at the tumor-host border was investigated. In 43 patients we evaluated the expression of 395 genes related to immune system activation through a next generation sequencing panel. Priority-LASSO models and clustering analyses were integrated with multivariate Cox proportional hazard modeling to identify independent genes associated with relapse and estimate hazard ratios in relation to gene expression and TILs. TILs and the expression of genes related with immune system activation (FCGR1A, IFNA17, FCRLA, NCR3, KREMEN1, CD14, CD3G, CD19, CD20 and CD79A) were significantly associated with prognostic factors or disease specific survival. In patients with lymph node metastases and advanced T stage (pT4), the expression of other genes was altered. Low TILs count was highly associated with relapse within 2 years (p |
| doi_str_mv | 10.1038/s41598-020-73747-0 |
| format | Article |
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We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the second group had no evidence of disease at 2 years. The presence of stromal tumor infiltrating lymphocytes (TILs) at the tumor-host border was investigated. In 43 patients we evaluated the expression of 395 genes related to immune system activation through a next generation sequencing panel. Priority-LASSO models and clustering analyses were integrated with multivariate Cox proportional hazard modeling to identify independent genes associated with relapse and estimate hazard ratios in relation to gene expression and TILs. TILs and the expression of genes related with immune system activation (FCGR1A, IFNA17, FCRLA, NCR3, KREMEN1, CD14, CD3G, CD19, CD20 and CD79A) were significantly associated with prognostic factors or disease specific survival. In patients with lymph node metastases and advanced T stage (pT4), the expression of other genes was altered. Low TILs count was highly associated with relapse within 2 years (p < 0.001). Low TILs and altered expression of specific genes associated with tumor-immune systems interactions emerged as independent risk factors, associated to poor prognosis and relapse within 2 years in advanced LSCC. Evaluation of patients’ immune profile could be useful for prognosis and future therapeutic approaches towards personalized therapy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-73747-0</identifier><identifier>PMID: 33110100</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/1619 ; 631/250/580 ; 631/67/1536 ; Aged ; CD14 antigen ; CD19 antigen ; CD20 antigen ; Disease-Free Survival ; Fc receptors ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic - genetics ; Humanities and Social Sciences ; Humans ; Immune system ; Immunity - genetics ; Immunity - immunology ; Laryngeal cancer ; Laryngeal Neoplasms - diagnosis ; Laryngeal Neoplasms - immunology ; Laryngeal Neoplasms - pathology ; Lymph nodes ; Lymphocytes ; Lymphocytes, Tumor-Infiltrating - immunology ; Lymphocytes, Tumor-Infiltrating - pathology ; Male ; Medical prognosis ; Metastases ; Middle Aged ; multidisciplinary ; Neoplasm Recurrence, Local - immunology ; Neoplasm Recurrence, Local - metabolism ; Next-generation sequencing ; Prognosis ; Retrospective Studies ; Risk factors ; Science ; Science (multidisciplinary) ; Sequence Analysis, RNA ; Squamous cell carcinoma</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.18327, Article 18327</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the second group had no evidence of disease at 2 years. The presence of stromal tumor infiltrating lymphocytes (TILs) at the tumor-host border was investigated. In 43 patients we evaluated the expression of 395 genes related to immune system activation through a next generation sequencing panel. Priority-LASSO models and clustering analyses were integrated with multivariate Cox proportional hazard modeling to identify independent genes associated with relapse and estimate hazard ratios in relation to gene expression and TILs. TILs and the expression of genes related with immune system activation (FCGR1A, IFNA17, FCRLA, NCR3, KREMEN1, CD14, CD3G, CD19, CD20 and CD79A) were significantly associated with prognostic factors or disease specific survival. In patients with lymph node metastases and advanced T stage (pT4), the expression of other genes was altered. Low TILs count was highly associated with relapse within 2 years (p < 0.001). Low TILs and altered expression of specific genes associated with tumor-immune systems interactions emerged as independent risk factors, associated to poor prognosis and relapse within 2 years in advanced LSCC. Evaluation of patients’ immune profile could be useful for prognosis and future therapeutic approaches towards personalized therapy.</description><subject>631/250/1619</subject><subject>631/250/580</subject><subject>631/67/1536</subject><subject>Aged</subject><subject>CD14 antigen</subject><subject>CD19 antigen</subject><subject>CD20 antigen</subject><subject>Disease-Free Survival</subject><subject>Fc receptors</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity - genetics</subject><subject>Immunity - immunology</subject><subject>Laryngeal cancer</subject><subject>Laryngeal Neoplasms - diagnosis</subject><subject>Laryngeal Neoplasms - immunology</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Lymph 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Maria</au><au>Alterio, Daniela</au><au>Guerini Rocco, Elena</au><au>Cattaneo, Augusto</au><au>Chu, Francesco</au><au>Zorzi, Stefano</au><au>Curigliano, Giuseppe</au><au>Chiocca, Susanna</au><au>Barberis, Massimo</au><au>Viale, Giuseppe</au><au>Ansarin, Mohssen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A role for the immune system in advanced laryngeal cancer</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-10-27</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>18327</spage><pages>18327-</pages><artnum>18327</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>To investigate the role of the altered activation of the immune system in the prognosis of patients affected by laryngeal squamous cell carcinoma (LSCC). We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the second group had no evidence of disease at 2 years. The presence of stromal tumor infiltrating lymphocytes (TILs) at the tumor-host border was investigated. In 43 patients we evaluated the expression of 395 genes related to immune system activation through a next generation sequencing panel. Priority-LASSO models and clustering analyses were integrated with multivariate Cox proportional hazard modeling to identify independent genes associated with relapse and estimate hazard ratios in relation to gene expression and TILs. TILs and the expression of genes related with immune system activation (FCGR1A, IFNA17, FCRLA, NCR3, KREMEN1, CD14, CD3G, CD19, CD20 and CD79A) were significantly associated with prognostic factors or disease specific survival. In patients with lymph node metastases and advanced T stage (pT4), the expression of other genes was altered. Low TILs count was highly associated with relapse within 2 years (p < 0.001). Low TILs and altered expression of specific genes associated with tumor-immune systems interactions emerged as independent risk factors, associated to poor prognosis and relapse within 2 years in advanced LSCC. Evaluation of patients’ immune profile could be useful for prognosis and future therapeutic approaches towards personalized therapy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33110100</pmid><doi>10.1038/s41598-020-73747-0</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/250/1619 631/250/580 631/67/1536 Aged CD14 antigen CD19 antigen CD20 antigen Disease-Free Survival Fc receptors Female Gene expression Gene Expression Regulation, Neoplastic - genetics Humanities and Social Sciences Humans Immune system Immunity - genetics Immunity - immunology Laryngeal cancer Laryngeal Neoplasms - diagnosis Laryngeal Neoplasms - immunology Laryngeal Neoplasms - pathology Lymph nodes Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Male Medical prognosis Metastases Middle Aged multidisciplinary Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - metabolism Next-generation sequencing Prognosis Retrospective Studies Risk factors Science Science (multidisciplinary) Sequence Analysis, RNA Squamous cell carcinoma |
| title | A role for the immune system in advanced laryngeal cancer |
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