Longevity, clonal relationship, and transcriptional program of celiac disease-specific plasma cells

Disease-specific plasma cells (PCs) reactive with transglutaminase 2 (TG2) or deamidated gluten peptides (DGPs) are abundant in celiac disease (CeD) gut lesions. Their contribution toward CeD pathogenesis is unclear. We assessed expression of markers associated with PC longevity in 15 untreated and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 2021-02, Vol.218 (2)
Hauptverfasser:	Lindeman, Ida, Zhou, Chunyan, Eggesbø, Linn M, Miao, Zhichao, Polak, Justyna, Lundin, Knut E A, Jahnsen, Jørgen, Qiao, Shuo-Wang, Iversen, Rasmus, Sollid, Ludvig M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibody Formation - genetics Antigens, CD19 - genetics Autoimmunity Celiac Disease - genetics Cell Line Gene Expression Profiling - methods Glutens - genetics GTP-Binding Proteins - genetics Humans Immunoglobulin A - genetics Immunoglobulin Heavy Chains - genetics Leukocyte Common Antigens - genetics Longevity - genetics Mucosal Immunology Plasma Cells - physiology Polymorphism, Genetic - genetics Protein Glutamine gamma Glutamyltransferase 2 Sf9 Cells Transcription, Genetic - genetics Transglutaminases - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!