The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening thrombotic microangiopathy caused by severe ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13) deficiency, recurring in 30–50% of patients. The common human leukocyte antigen (HLA) varian...

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Veröffentlicht in:	Journal of clinical medicine 2020-10, Vol.9 (10), p.3379
Hauptverfasser:	Mancini, Ilaria, Giacomini, Elisa, Pontiggia, Silvia, Artoni, Andrea, Ferrari, Barbara, Pappalardo, Emanuela, Gualtierotti, Roberta, Trisolini, Silvia Maria, Capria, Saveria, Facchini, Luca, Codeluppi, Katia, Rinaldi, Erminia, Pastore, Domenico, Campus, Simona, Caria, Cinzia, Caddori, Aldo, Nicolosi, Daniela, Giuffrida, Gaetano, Agostini, Vanessa, Roncarati, Umberto, Mannarella, Clara, Fragasso, Alberto, Podda, Gian Marco, Birocchi, Simone, Cerbone, Anna Maria, Tufano, Antonella, Menna, Giuseppe, Pizzuti, Michele, Ronchi, Michela, De Fanti, Alessandro, Amarri, Sergio, Defina, Marzia, Bocchia, Monica, Cerù, Silvia, Gattillo, Salvatore, Rosendaal, Frits R., Peyvandi, Flora
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Antibodies Autoimmune diseases Clinical medicine Disease Genotype & phenotype Health risk assessment HIV Human immunodeficiency virus Laboratories Patients Purpura Regression analysis Remission (Medicine) Thrombocytopenia Thrombosis White people
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