Proteomic Characterization of Urinary Extracellular Vesicles from Kidney-Transplanted Patients Treated with Calcineurin Inhibitors

Use of immunosuppressive drugs is still unavoidable in kidney-transplanted patients. Since their discovery, calcineurin inhibitors (CNI) have been considered the first-line immunosuppressive agents, in spite of their known nephrotoxicity. Chronic CNI toxicity (CNIT) may lead to kidney fibrosis, a th...

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Veröffentlicht in:	International journal of molecular sciences 2020-10, Vol.21 (20), p.7569
Hauptverfasser:	Carreras-Planella, Laura, Juega, Javier, Taco, Omar, Cañas, Laura, Franquesa, Marcella, Lauzurica, Ricardo, Borràs, Francesc Enric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Atrophy Biomarkers Biomarkers - urine Biopsy Calcineurin Calcineurin inhibitors Calcineurin Inhibitors - pharmacology Calcineurin Inhibitors - therapeutic use Cell cycle Creatinine Cyclosporine - pharmacology Cyclosporine - therapeutic use Disease management Extracellular vesicles Extracellular Vesicles - metabolism Female Fibrosis Graft Survival Humans Immunosuppressive agents Inhibitors Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - etiology Kidney Diseases - prevention & control Kidney Transplantation - adverse effects Kidney Transplantation - methods Kidney transplants Kidneys Male Middle Aged Monitoring Patients Plakins - urine Principal components analysis Protein sources Proteins Proteome - genetics Proteome - metabolism Proteomes Scientific imaging Tacrolimus - pharmacology Tacrolimus - therapeutic use Toxicity Urine Uroplakins - urine Vesicles
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