Postsynthetic Functionalization of DNA‐Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applications

We report on the directed postsynthetic functionalization of soft DNA nanocomposite materials with proteins. Using the example of the functionalization of silica nanoparticle‐modified DNA polymer materials with agonists or antagonists of the epidermal growth factor receptor EGFR cell membrane recept...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-10, Vol.59 (43), p.19016-19020
Hauptverfasser:	Hu, Yong, Domínguez, Carmen M., Christ, Sophina, Niemeyer, Christof M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology Cell culture Cell Culture Techniques Cell membranes Communication Communications Deoxyribonucleic acid DNA DNA - chemistry DNA nanocomposites DNA origami nanostructure Epidermal growth factor epidermal growth factor receptor Epidermal growth factor receptors ErbB Receptors - drug effects ErbB Receptors - metabolism Growth factors Humans Interfaces MCF-7 Cells Microscopy, Fluorescence - methods Modular design Nanocomposites Nanoparticles Nanoparticles - chemistry Phosphorylation Polymers Proteins Proteins - chemistry protein–DNA conjugates Receptors Silica Silicon dioxide Silicon Dioxide - chemistry
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