SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

A novel SARS-related coronavirus (SARS-CoV-2) has recently emerged as a serious pathogen that causes high morbidity and substantial mortality. However, the mechanisms by which SARS-CoV-2 evades host immunity remain poorly understood. Here, we identified SARS-CoV-2 membrane glycoprotein M as a negati...

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Veröffentlicht in:	Cellular & molecular immunology 2021-03, Vol.18 (3), p.613-620
Hauptverfasser:	Fu, Yu-Zhi, Wang, Su-Yun, Zheng, Zhou-Qin, Yi Huang, Li, Wei-Wei, Xu, Zhi-Sheng, Wang, Yan-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2161 631/250/262 Adaptor Proteins, Signal Transducing - immunology Antibodies Antiviral drugs Biomedical and Life Sciences Biomedicine Coronaviruses COVID-19 - immunology Glycoproteins HEK293 Cells HeLa Cells Humans Immune response Immunity, Innate Immunology Innate immunity Interferon regulatory factor 3 M protein Medical Microbiology Microbiology Morbidity Proteins SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Signal Transduction - immunology Vaccine Viral Matrix Proteins - immunology
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