Electrocorticographic patterns dominated by low-frequency waves in camphor-induced seizures
Camphor is an aromatic terpene compound found in the essential oils of many plants, which has been used for centuries as a herbal medicine, especially in children. However, many studies have shown that camphor may have major side effects, including neurological manifestation, such as seizures. In th...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2020-10, Vol.10 (1), p.18222, Article 18222 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 18222 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Ferreira, Luan Oliveira de Souza, Rafael Dias de Araújo Silva, Fabrício Costa, Francisco Fabrizio Moraes Farias, Rômulo Augusto Feio Hamoy, Akira Otake de Mello, Vanessa Jóia Lopes, Dielly Catrina Favacho Hamoy, Moisés |
| description | Camphor is an aromatic terpene compound found in the essential oils of many plants, which has been used for centuries as a herbal medicine, especially in children. However, many studies have shown that camphor may have major side effects, including neurological manifestation, such as seizures. In the present study, we investigated the electrocorticographic patterns of seizures induced by camphor in male adult Wistar rats. Each rat received 400 mg/kg (i.p.) of camphor prior to monitoring by electrocorticography. The application of camphor resulted a rapid evolution to seizure and marked changes in the electrocorticographic readings, which presented characteristics of epileptiform activity, with an increase in the total power wave. The decomposition of the cerebral waves revealed an increase in the delta and theta waves. The analysis of the camphor traces revealed severe ictal activity marked by an increase in the polyspike wave. Our data thus indicate that camphor may cause seizures, leading to tonic–clonic seizures. Clearly, further studies are necessary to better elucidate the mechanisms through which camphor acts on the brain, and to propose potential treatments with anticonvulsant drugs that are effective for the control of the seizures. |
| doi_str_mv | 10.1038/s41598-020-75309-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7588455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471522596</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-a7e8e9e3d8ff98463640ad7f91a209249c0f8ac3121c803ddec5b2abd9a35b233</originalsourceid><addsrcrecordid>eNp9kU1rGzEQhkVoiE2SP5BDWehZqT690qVQTJoUAr0kpxyELM3aMra0lXZjnF9fpc5XL53LDMw778zwIHRBySUlXH0tgkqtMGEEt5ITjXdHaMqIkJhxxj59qCfovJQ1qSGZFlSfoAnnlMxkK6bo4WoDbsjJpTwEl5bZ9qvgmt4OA-RYGp-2IdoBfLPYN5u0w12G3yNEt2929hFKE2Lj7LZfpYxD9KOrygLhacxQztBxZzcFzl_yKbr_cXU3v8G3v65_zr_fYidaMWDbggIN3Kuu00rM-EwQ69tOU8uIZkI70inrOGXUKcK9BycXzC68trwWnJ-ibwffflxswTuIQ7Yb0-ewtXlvkg3m304MK7NMj6aVSgkpq8GXF4Oc6nNlMOs05lhvNky0VDIm9ayq2EHlciolQ_e2gRLzzMQcmJjKxPxlYnZ16PPH295GXglUAT8ISm3FJeT33f-x_QNzpJsO</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471522596</pqid></control><display><type>article</type><title>Electrocorticographic patterns dominated by low-frequency waves in camphor-induced seizures</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Ferreira, Luan Oliveira ; de Souza, Rafael Dias ; de Araújo Silva, Fabrício ; Costa, Francisco Fabrizio Moraes ; Farias, Rômulo Augusto Feio ; Hamoy, Akira Otake ; de Mello, Vanessa Jóia ; Lopes, Dielly Catrina Favacho ; Hamoy, Moisés</creator><creatorcontrib>Ferreira, Luan Oliveira ; de Souza, Rafael Dias ; de Araújo Silva, Fabrício ; Costa, Francisco Fabrizio Moraes ; Farias, Rômulo Augusto Feio ; Hamoy, Akira Otake ; de Mello, Vanessa Jóia ; Lopes, Dielly Catrina Favacho ; Hamoy, Moisés</creatorcontrib><description>Camphor is an aromatic terpene compound found in the essential oils of many plants, which has been used for centuries as a herbal medicine, especially in children. However, many studies have shown that camphor may have major side effects, including neurological manifestation, such as seizures. In the present study, we investigated the electrocorticographic patterns of seizures induced by camphor in male adult Wistar rats. Each rat received 400 mg/kg (i.p.) of camphor prior to monitoring by electrocorticography. The application of camphor resulted a rapid evolution to seizure and marked changes in the electrocorticographic readings, which presented characteristics of epileptiform activity, with an increase in the total power wave. The decomposition of the cerebral waves revealed an increase in the delta and theta waves. The analysis of the camphor traces revealed severe ictal activity marked by an increase in the polyspike wave. Our data thus indicate that camphor may cause seizures, leading to tonic–clonic seizures. Clearly, further studies are necessary to better elucidate the mechanisms through which camphor acts on the brain, and to propose potential treatments with anticonvulsant drugs that are effective for the control of the seizures.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-75309-w</identifier><identifier>PMID: 33106574</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378 ; 631/378/1689 ; 631/378/1689/178 ; Animals ; Annual reports ; Anti-Infective Agents, Local - toxicity ; Anticonvulsants ; Brain - drug effects ; Brain - pathology ; Camphor ; Camphor - toxicity ; Convulsions & seizures ; Decomposition ; Delta Rhythm ; Drug dosages ; Electrocorticography - methods ; Epilepsy ; Essential oils ; Herbal medicine ; Humanities and Social Sciences ; Male ; Medicinal plants ; multidisciplinary ; Oils & fats ; Poisoning ; Rats ; Rats, Wistar ; Science ; Science (multidisciplinary) ; Seizures ; Seizures - chemically induced ; Seizures - pathology ; Side effects ; Software ; Theta Rhythm</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.18222, Article 18222</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-a7e8e9e3d8ff98463640ad7f91a209249c0f8ac3121c803ddec5b2abd9a35b233</citedby><cites>FETCH-LOGICAL-c474t-a7e8e9e3d8ff98463640ad7f91a209249c0f8ac3121c803ddec5b2abd9a35b233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588455/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588455/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33106574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferreira, Luan Oliveira</creatorcontrib><creatorcontrib>de Souza, Rafael Dias</creatorcontrib><creatorcontrib>de Araújo Silva, Fabrício</creatorcontrib><creatorcontrib>Costa, Francisco Fabrizio Moraes</creatorcontrib><creatorcontrib>Farias, Rômulo Augusto Feio</creatorcontrib><creatorcontrib>Hamoy, Akira Otake</creatorcontrib><creatorcontrib>de Mello, Vanessa Jóia</creatorcontrib><creatorcontrib>Lopes, Dielly Catrina Favacho</creatorcontrib><creatorcontrib>Hamoy, Moisés</creatorcontrib><title>Electrocorticographic patterns dominated by low-frequency waves in camphor-induced seizures</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Camphor is an aromatic terpene compound found in the essential oils of many plants, which has been used for centuries as a herbal medicine, especially in children. However, many studies have shown that camphor may have major side effects, including neurological manifestation, such as seizures. In the present study, we investigated the electrocorticographic patterns of seizures induced by camphor in male adult Wistar rats. Each rat received 400 mg/kg (i.p.) of camphor prior to monitoring by electrocorticography. The application of camphor resulted a rapid evolution to seizure and marked changes in the electrocorticographic readings, which presented characteristics of epileptiform activity, with an increase in the total power wave. The decomposition of the cerebral waves revealed an increase in the delta and theta waves. The analysis of the camphor traces revealed severe ictal activity marked by an increase in the polyspike wave. Our data thus indicate that camphor may cause seizures, leading to tonic–clonic seizures. Clearly, further studies are necessary to better elucidate the mechanisms through which camphor acts on the brain, and to propose potential treatments with anticonvulsant drugs that are effective for the control of the seizures.</description><subject>631/378</subject><subject>631/378/1689</subject><subject>631/378/1689/178</subject><subject>Animals</subject><subject>Annual reports</subject><subject>Anti-Infective Agents, Local - toxicity</subject><subject>Anticonvulsants</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>Camphor</subject><subject>Camphor - toxicity</subject><subject>Convulsions & seizures</subject><subject>Decomposition</subject><subject>Delta Rhythm</subject><subject>Drug dosages</subject><subject>Electrocorticography - methods</subject><subject>Epilepsy</subject><subject>Essential oils</subject><subject>Herbal medicine</subject><subject>Humanities and Social Sciences</subject><subject>Male</subject><subject>Medicinal plants</subject><subject>multidisciplinary</subject><subject>Oils & fats</subject><subject>Poisoning</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Seizures</subject><subject>Seizures - chemically induced</subject><subject>Seizures - pathology</subject><subject>Side effects</subject><subject>Software</subject><subject>Theta Rhythm</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rGzEQhkVoiE2SP5BDWehZqT690qVQTJoUAr0kpxyELM3aMra0lXZjnF9fpc5XL53LDMw778zwIHRBySUlXH0tgkqtMGEEt5ITjXdHaMqIkJhxxj59qCfovJQ1qSGZFlSfoAnnlMxkK6bo4WoDbsjJpTwEl5bZ9qvgmt4OA-RYGp-2IdoBfLPYN5u0w12G3yNEt2929hFKE2Lj7LZfpYxD9KOrygLhacxQztBxZzcFzl_yKbr_cXU3v8G3v65_zr_fYidaMWDbggIN3Kuu00rM-EwQ69tOU8uIZkI70inrOGXUKcK9BycXzC68trwWnJ-ibwffflxswTuIQ7Yb0-ewtXlvkg3m304MK7NMj6aVSgkpq8GXF4Oc6nNlMOs05lhvNky0VDIm9ayq2EHlciolQ_e2gRLzzMQcmJjKxPxlYnZ16PPH295GXglUAT8ISm3FJeT33f-x_QNzpJsO</recordid><startdate>20201026</startdate><enddate>20201026</enddate><creator>Ferreira, Luan Oliveira</creator><creator>de Souza, Rafael Dias</creator><creator>de Araújo Silva, Fabrício</creator><creator>Costa, Francisco Fabrizio Moraes</creator><creator>Farias, Rômulo Augusto Feio</creator><creator>Hamoy, Akira Otake</creator><creator>de Mello, Vanessa Jóia</creator><creator>Lopes, Dielly Catrina Favacho</creator><creator>Hamoy, Moisés</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20201026</creationdate><title>Electrocorticographic patterns dominated by low-frequency waves in camphor-induced seizures</title><author>Ferreira, Luan Oliveira ; de Souza, Rafael Dias ; de Araújo Silva, Fabrício ; Costa, Francisco Fabrizio Moraes ; Farias, Rômulo Augusto Feio ; Hamoy, Akira Otake ; de Mello, Vanessa Jóia ; Lopes, Dielly Catrina Favacho ; Hamoy, Moisés</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-a7e8e9e3d8ff98463640ad7f91a209249c0f8ac3121c803ddec5b2abd9a35b233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/378</topic><topic>631/378/1689</topic><topic>631/378/1689/178</topic><topic>Animals</topic><topic>Annual reports</topic><topic>Anti-Infective Agents, Local - toxicity</topic><topic>Anticonvulsants</topic><topic>Brain - drug effects</topic><topic>Brain - pathology</topic><topic>Camphor</topic><topic>Camphor - toxicity</topic><topic>Convulsions & seizures</topic><topic>Decomposition</topic><topic>Delta Rhythm</topic><topic>Drug dosages</topic><topic>Electrocorticography - methods</topic><topic>Epilepsy</topic><topic>Essential oils</topic><topic>Herbal medicine</topic><topic>Humanities and Social Sciences</topic><topic>Male</topic><topic>Medicinal plants</topic><topic>multidisciplinary</topic><topic>Oils & fats</topic><topic>Poisoning</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Seizures</topic><topic>Seizures - chemically induced</topic><topic>Seizures - pathology</topic><topic>Side effects</topic><topic>Software</topic><topic>Theta Rhythm</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferreira, Luan Oliveira</creatorcontrib><creatorcontrib>de Souza, Rafael Dias</creatorcontrib><creatorcontrib>de Araújo Silva, Fabrício</creatorcontrib><creatorcontrib>Costa, Francisco Fabrizio Moraes</creatorcontrib><creatorcontrib>Farias, Rômulo Augusto Feio</creatorcontrib><creatorcontrib>Hamoy, Akira Otake</creatorcontrib><creatorcontrib>de Mello, Vanessa Jóia</creatorcontrib><creatorcontrib>Lopes, Dielly Catrina Favacho</creatorcontrib><creatorcontrib>Hamoy, Moisés</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferreira, Luan Oliveira</au><au>de Souza, Rafael Dias</au><au>de Araújo Silva, Fabrício</au><au>Costa, Francisco Fabrizio Moraes</au><au>Farias, Rômulo Augusto Feio</au><au>Hamoy, Akira Otake</au><au>de Mello, Vanessa Jóia</au><au>Lopes, Dielly Catrina Favacho</au><au>Hamoy, Moisés</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrocorticographic patterns dominated by low-frequency waves in camphor-induced seizures</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-10-26</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>18222</spage><pages>18222-</pages><artnum>18222</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Camphor is an aromatic terpene compound found in the essential oils of many plants, which has been used for centuries as a herbal medicine, especially in children. However, many studies have shown that camphor may have major side effects, including neurological manifestation, such as seizures. In the present study, we investigated the electrocorticographic patterns of seizures induced by camphor in male adult Wistar rats. Each rat received 400 mg/kg (i.p.) of camphor prior to monitoring by electrocorticography. The application of camphor resulted a rapid evolution to seizure and marked changes in the electrocorticographic readings, which presented characteristics of epileptiform activity, with an increase in the total power wave. The decomposition of the cerebral waves revealed an increase in the delta and theta waves. The analysis of the camphor traces revealed severe ictal activity marked by an increase in the polyspike wave. Our data thus indicate that camphor may cause seizures, leading to tonic–clonic seizures. Clearly, further studies are necessary to better elucidate the mechanisms through which camphor acts on the brain, and to propose potential treatments with anticonvulsant drugs that are effective for the control of the seizures.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33106574</pmid><doi>10.1038/s41598-020-75309-w</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-10, Vol.10 (1), p.18222, Article 18222 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7588455 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 631/378 631/378/1689 631/378/1689/178 Animals Annual reports Anti-Infective Agents, Local - toxicity Anticonvulsants Brain - drug effects Brain - pathology Camphor Camphor - toxicity Convulsions & seizures Decomposition Delta Rhythm Drug dosages Electrocorticography - methods Epilepsy Essential oils Herbal medicine Humanities and Social Sciences Male Medicinal plants multidisciplinary Oils & fats Poisoning Rats Rats, Wistar Science Science (multidisciplinary) Seizures Seizures - chemically induced Seizures - pathology Side effects Software Theta Rhythm |
| title | Electrocorticographic patterns dominated by low-frequency waves in camphor-induced seizures |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T08%3A56%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Electrocorticographic%20patterns%20dominated%20by%20low-frequency%20waves%20in%20camphor-induced%20seizures&rft.jtitle=Scientific%20reports&rft.au=Ferreira,%20Luan%20Oliveira&rft.date=2020-10-26&rft.volume=10&rft.issue=1&rft.spage=18222&rft.pages=18222-&rft.artnum=18222&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-75309-w&rft_dat=%3Cproquest_pubme%3E2471522596%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471522596&rft_id=info:pmid/33106574&rfr_iscdi=true |