Prognostic impact of malignant diseases in idiopathic pulmonary fibrosis
No studies on idiopathic pulmonary fibrosis (IPF) have investigated the prognostic impact of extrapulmonary cancers in patients with IPF. We aimed to determine the prognostic impact of malignancies in patients with IPF. We retrospectively reviewed the medical records of patients diagnosed with IPF b...
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description | No studies on idiopathic pulmonary fibrosis (IPF) have investigated the prognostic impact of extrapulmonary cancers in patients with IPF. We aimed to determine the prognostic impact of malignancies in patients with IPF. We retrospectively reviewed the medical records of patients diagnosed with IPF between 2001 and 2015. Patients were divided into three groups: IPF without cancer (n = 440), IPF with lung cancer (n = 69), and IPF with extrapulmonary cancer (n = 70). Of the 579 patients with IPF, 139 (24%) had cancer; the three most common types were lung (11.9%), gastric (2.4%), and colorectal (1.9%). Survival was significantly worse in patients with lung cancer than in those without cancer (hazard ratio [HR] = 1.83, 95% confidence interval [CI], 1.35–2.48) or those with extrapulmonary cancer (HR = 1.70, 95% CI, 1.14–2.54). The rate of hospitalisation for cancer-related complications was significantly higher in IPF patients with lung cancer than in those with extrapulmonary cancer. The annual rates of decline in percent predicted forced vital capacity and diffusion capacity for carbon monoxide did not differ among the groups. Physicians should pay attention to the development and progression of cancer and its prognostic impact in patients with IPF. |
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We aimed to determine the prognostic impact of malignancies in patients with IPF. We retrospectively reviewed the medical records of patients diagnosed with IPF between 2001 and 2015. Patients were divided into three groups: IPF without cancer (n = 440), IPF with lung cancer (n = 69), and IPF with extrapulmonary cancer (n = 70). Of the 579 patients with IPF, 139 (24%) had cancer; the three most common types were lung (11.9%), gastric (2.4%), and colorectal (1.9%). Survival was significantly worse in patients with lung cancer than in those without cancer (hazard ratio [HR] = 1.83, 95% confidence interval [CI], 1.35–2.48) or those with extrapulmonary cancer (HR = 1.70, 95% CI, 1.14–2.54). The rate of hospitalisation for cancer-related complications was significantly higher in IPF patients with lung cancer than in those with extrapulmonary cancer. The annual rates of decline in percent predicted forced vital capacity and diffusion capacity for carbon monoxide did not differ among the groups. Physicians should pay attention to the development and progression of cancer and its prognostic impact in patients with IPF.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-75276-2</identifier><identifier>PMID: 33106517</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308 ; 692/4028 ; 692/699 ; Aged ; Carbon monoxide ; Colorectal cancer ; Databases, Factual ; Disease Progression ; Female ; Fibrosis ; Gastric cancer ; Humanities and Social Sciences ; Humans ; Idiopathic Pulmonary Fibrosis - complications ; Idiopathic Pulmonary Fibrosis - pathology ; Lung cancer ; Lung diseases ; Lung Neoplasms - etiology ; Lung Neoplasms - pathology ; Male ; Medical records ; Middle Aged ; multidisciplinary ; Neoplasms - etiology ; Neoplasms - pathology ; Prognosis ; Pulmonary fibrosis ; Retrospective Studies ; Risk Factors ; Science ; Science (multidisciplinary) ; Survival Rate ; Tomography, X-Ray Computed - methods</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.18260-18260, Article 18260</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b526a1ebccec2024e4f689d01c6977aba0703702a444c63c9585c38660569f2b3</citedby><cites>FETCH-LOGICAL-c474t-b526a1ebccec2024e4f689d01c6977aba0703702a444c63c9585c38660569f2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588444/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588444/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33106517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Hong Yeul</creatorcontrib><creatorcontrib>Cho, Jaeyoung</creatorcontrib><creatorcontrib>Kwak, Nakwon</creatorcontrib><creatorcontrib>Lee, Jinwoo</creatorcontrib><creatorcontrib>Park, Young Sik</creatorcontrib><creatorcontrib>Lee, Chang-Hoon</creatorcontrib><creatorcontrib>Lee, Sang-Min</creatorcontrib><creatorcontrib>Yoo, Chul-Gyu</creatorcontrib><creatorcontrib>Kim, Young Whan</creatorcontrib><creatorcontrib>Choi, Sun Mi</creatorcontrib><title>Prognostic impact of malignant diseases in idiopathic pulmonary fibrosis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>No studies on idiopathic pulmonary fibrosis (IPF) have investigated the prognostic impact of extrapulmonary cancers in patients with IPF. We aimed to determine the prognostic impact of malignancies in patients with IPF. We retrospectively reviewed the medical records of patients diagnosed with IPF between 2001 and 2015. Patients were divided into three groups: IPF without cancer (n = 440), IPF with lung cancer (n = 69), and IPF with extrapulmonary cancer (n = 70). Of the 579 patients with IPF, 139 (24%) had cancer; the three most common types were lung (11.9%), gastric (2.4%), and colorectal (1.9%). Survival was significantly worse in patients with lung cancer than in those without cancer (hazard ratio [HR] = 1.83, 95% confidence interval [CI], 1.35–2.48) or those with extrapulmonary cancer (HR = 1.70, 95% CI, 1.14–2.54). The rate of hospitalisation for cancer-related complications was significantly higher in IPF patients with lung cancer than in those with extrapulmonary cancer. The annual rates of decline in percent predicted forced vital capacity and diffusion capacity for carbon monoxide did not differ among the groups. Physicians should pay attention to the development and progression of cancer and its prognostic impact in patients with IPF.</description><subject>692/308</subject><subject>692/4028</subject><subject>692/699</subject><subject>Aged</subject><subject>Carbon monoxide</subject><subject>Colorectal cancer</subject><subject>Databases, Factual</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gastric cancer</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Idiopathic Pulmonary Fibrosis - complications</subject><subject>Idiopathic Pulmonary Fibrosis - pathology</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical records</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - 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complications</topic><topic>Idiopathic Pulmonary Fibrosis - pathology</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - etiology</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical records</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - pathology</topic><topic>Prognosis</topic><topic>Pulmonary fibrosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Survival Rate</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Hong Yeul</creatorcontrib><creatorcontrib>Cho, Jaeyoung</creatorcontrib><creatorcontrib>Kwak, Nakwon</creatorcontrib><creatorcontrib>Lee, Jinwoo</creatorcontrib><creatorcontrib>Park, Young Sik</creatorcontrib><creatorcontrib>Lee, Chang-Hoon</creatorcontrib><creatorcontrib>Lee, Sang-Min</creatorcontrib><creatorcontrib>Yoo, Chul-Gyu</creatorcontrib><creatorcontrib>Kim, Young Whan</creatorcontrib><creatorcontrib>Choi, Sun Mi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Hong Yeul</au><au>Cho, Jaeyoung</au><au>Kwak, Nakwon</au><au>Lee, Jinwoo</au><au>Park, Young Sik</au><au>Lee, Chang-Hoon</au><au>Lee, Sang-Min</au><au>Yoo, Chul-Gyu</au><au>Kim, Young Whan</au><au>Choi, Sun Mi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic impact of malignant diseases in idiopathic pulmonary fibrosis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-10-26</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>18260</spage><epage>18260</epage><pages>18260-18260</pages><artnum>18260</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>No studies on idiopathic pulmonary fibrosis (IPF) have investigated the prognostic impact of extrapulmonary cancers in patients with IPF. We aimed to determine the prognostic impact of malignancies in patients with IPF. We retrospectively reviewed the medical records of patients diagnosed with IPF between 2001 and 2015. Patients were divided into three groups: IPF without cancer (n = 440), IPF with lung cancer (n = 69), and IPF with extrapulmonary cancer (n = 70). Of the 579 patients with IPF, 139 (24%) had cancer; the three most common types were lung (11.9%), gastric (2.4%), and colorectal (1.9%). Survival was significantly worse in patients with lung cancer than in those without cancer (hazard ratio [HR] = 1.83, 95% confidence interval [CI], 1.35–2.48) or those with extrapulmonary cancer (HR = 1.70, 95% CI, 1.14–2.54). The rate of hospitalisation for cancer-related complications was significantly higher in IPF patients with lung cancer than in those with extrapulmonary cancer. The annual rates of decline in percent predicted forced vital capacity and diffusion capacity for carbon monoxide did not differ among the groups. Physicians should pay attention to the development and progression of cancer and its prognostic impact in patients with IPF.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33106517</pmid><doi>10.1038/s41598-020-75276-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 692/308 692/4028 692/699 Aged Carbon monoxide Colorectal cancer Databases, Factual Disease Progression Female Fibrosis Gastric cancer Humanities and Social Sciences Humans Idiopathic Pulmonary Fibrosis - complications Idiopathic Pulmonary Fibrosis - pathology Lung cancer Lung diseases Lung Neoplasms - etiology Lung Neoplasms - pathology Male Medical records Middle Aged multidisciplinary Neoplasms - etiology Neoplasms - pathology Prognosis Pulmonary fibrosis Retrospective Studies Risk Factors Science Science (multidisciplinary) Survival Rate Tomography, X-Ray Computed - methods |
title | Prognostic impact of malignant diseases in idiopathic pulmonary fibrosis |
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