Prognostic impact of malignant diseases in idiopathic pulmonary fibrosis

No studies on idiopathic pulmonary fibrosis (IPF) have investigated the prognostic impact of extrapulmonary cancers in patients with IPF. We aimed to determine the prognostic impact of malignancies in patients with IPF. We retrospectively reviewed the medical records of patients diagnosed with IPF b...

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Veröffentlicht in:Scientific reports 2020-10, Vol.10 (1), p.18260-18260, Article 18260
Hauptverfasser: Lee, Hong Yeul, Cho, Jaeyoung, Kwak, Nakwon, Lee, Jinwoo, Park, Young Sik, Lee, Chang-Hoon, Lee, Sang-Min, Yoo, Chul-Gyu, Kim, Young Whan, Choi, Sun Mi
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container_title Scientific reports
container_volume 10
creator Lee, Hong Yeul
Cho, Jaeyoung
Kwak, Nakwon
Lee, Jinwoo
Park, Young Sik
Lee, Chang-Hoon
Lee, Sang-Min
Yoo, Chul-Gyu
Kim, Young Whan
Choi, Sun Mi
description No studies on idiopathic pulmonary fibrosis (IPF) have investigated the prognostic impact of extrapulmonary cancers in patients with IPF. We aimed to determine the prognostic impact of malignancies in patients with IPF. We retrospectively reviewed the medical records of patients diagnosed with IPF between 2001 and 2015. Patients were divided into three groups: IPF without cancer (n = 440), IPF with lung cancer (n = 69), and IPF with extrapulmonary cancer (n = 70). Of the 579 patients with IPF, 139 (24%) had cancer; the three most common types were lung (11.9%), gastric (2.4%), and colorectal (1.9%). Survival was significantly worse in patients with lung cancer than in those without cancer (hazard ratio [HR] = 1.83, 95% confidence interval [CI], 1.35–2.48) or those with extrapulmonary cancer (HR = 1.70, 95% CI, 1.14–2.54). The rate of hospitalisation for cancer-related complications was significantly higher in IPF patients with lung cancer than in those with extrapulmonary cancer. The annual rates of decline in percent predicted forced vital capacity and diffusion capacity for carbon monoxide did not differ among the groups. Physicians should pay attention to the development and progression of cancer and its prognostic impact in patients with IPF.
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subjects 692/308
692/4028
692/699
Aged
Carbon monoxide
Colorectal cancer
Databases, Factual
Disease Progression
Female
Fibrosis
Gastric cancer
Humanities and Social Sciences
Humans
Idiopathic Pulmonary Fibrosis - complications
Idiopathic Pulmonary Fibrosis - pathology
Lung cancer
Lung diseases
Lung Neoplasms - etiology
Lung Neoplasms - pathology
Male
Medical records
Middle Aged
multidisciplinary
Neoplasms - etiology
Neoplasms - pathology
Prognosis
Pulmonary fibrosis
Retrospective Studies
Risk Factors
Science
Science (multidisciplinary)
Survival Rate
Tomography, X-Ray Computed - methods
title Prognostic impact of malignant diseases in idiopathic pulmonary fibrosis
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