Modifiers of Adeno-Associated Virus-Mediated Gene Expression in Implication for Serotype-Universal Neutralizing Antibody Assay

Adeno-associated virus (AAV)-based gene therapy is undergoing major expansion into clinical practice, with two treatments currently being granted Food and Drug Administration (FDA) approval. However, the presence of pre-existing neutralizing antibodies (NAB) is one of the significant hurdles for the...

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Veröffentlicht in:	Human gene therapy 2020-10, Vol.31 (19-20), p.1124-1131
Hauptverfasser:	Krotova, Karina, Aslanidi, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Diagnostic systems Gene expression Gene therapy Neutralizing Patients Protocol—Methods Regulatory agencies Serotypes Viruses
Online-Zugang:	Volltext
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